Anatomical, neurochemical and behavioural consequences of immunotoxin lesions of the basal forebrain cholinergic system.
The cholinergic hypothesis of geriatric memory dysfunction suggests that the learning and memory deficits representing the cardinal symptoms of dementia in the aged and in patients suffering from Alzheimer's disease may be attributable to a decline in the function of the cholinergic projection systems of the basal forebrain. Although many studies have addressed the issue of a causal relationship b