Search results

Filter

Filetype

Your search for "*" yielded 528606 hits

Estimating historical wage profiles

In this article, researchers evaluate the empirical performance of the Mincer earnings equation, which has been the benchmark model for assessment of wage profiles since 1974. The analysis concerns workers in the manufacturing industry in three countries before 1900. The Mincer equation must be adjusted with respect to functional form in order to capture the wage profiles of past industrial worker

Global structural motions from the strain of a single hydrogen bond

The origin and biological role of dynamic motions of folded enzymes is not yet fully understood. In this study, we examine the molecular determinants for the dynamic motions within the beta-barrel of superoxide dismutase 1 (SOD1), which previously were implicated in allosteric regulation of protein maturation and also pathological misfolding in the neurodegenerative disease amyotrophic lateral scl

A deadly spread: cellular mechanisms of α-synuclein transfer.

Classically, Parkinson's disease (PD) is linked to dopamine neuron death in the substantia nigra pars compacta. Intracytoplasmic protein inclusions named Lewy bodies, and corresponding Lewy neurites found in neuronal processes, are also key features of the degenerative process in the substantia nigra. The molecular mechanisms by which substantia nigra dopamine neurons die and whether the Lewy path

Prevalence of cerebral and pulmonary thrombosis in patients with cyanotic congenital heart disease.

Patients with cyanotic congenital heart disease (CCHD) have a high prevalence of thrombosis, the most frequently described locations being the cerebral and pulmonary vessels. The reported prevalence of both cerebral infarction and pulmonary thrombosis has been highly variable. The aim of this study was to examine the prevalence of both cerebral and pulmonary thrombosis in CCHD according to medical

Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.

Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own

A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5'-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nu

Hydrogen absorption and desorption properties of a novel ScNiAl alloy

A new hydrogen absorbing material has been discovered, ScNiAl, which can store 1.5 wt.% hydrogen reversibly. In this compound, hydrogen absorption is a two-step process; solid solution of hydrogen at temperatures below 180A degrees C and decomposition into ScH2 and NiAl at higher temperatures. Detailed analysis of the hydrogen absorption/desorption has been performed using in situ synchrotron radi

Evaluation of plasma A beta(40) and A beta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

Numerous studies have shown a marked decrease of beta-amyloid(42) (A beta(42)) in the cerebrospinal fluid (CSF) of patients with incipient Alzheimer's disease (AD). However, studies on A beta in plasma are contradictory, and show very marginal differences between patients and controls. Here, we analyzed plasma samples using a new multiplex immunoassay for simultaneous analysis of A beta(1-40), A b

Effects of Inflow and Radiofrequency Spoiling on the Arterial Input Function in Dynamic Contrast-Enhanced MRI: A Combined Phantom and Simulation Study

The arterial input function is crucial in pharmacokinetic analysis of dynamic contrast-enhanced MRI data. Among other artifacts in arterial input function quantification, the blood inflow effect and nonideal radiofrequency spoiling can induce large measurement errors with subsequent reduction of accuracy in the pharmacokinetic parameters. These errors were investigated for a 3D spoiled gradient-ec

Olfactory detectability of l-amino acids in the European honeybee (Apis mellifera)

The honeybee is one of several insect model systems for the study of olfaction, yet our knowledge regarding the spectrum of odorants detectable by Apis mellifera is limited. One class of odorants that has never been tested so far are the amino acids, which are important constituents of floral nectar. Using the proboscis extension response paradigm, we assessed whether the odor of amino acids is de

Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke

Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation. We studied the contribution of brain macrophage migration inhibitory factor (MIF) to functional recovery after permanent middle cerebral artery occlusion (pMCAo) in rats. In the cerebral cor

Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure.

Adrenomodulin (ADM) is a peptide hormone secreted in response to cellular strain such as ischemia and is believed to have a beneficial effect on the cardiovascular system. However, the epidemiological relationships between ADM and measurements of haemodynamics, arteriosclerosis and atherosclerosis are not well established. The aim of this study was to investigate the association between the mid-re

Inverse carbon dioxide flux estimates for the Netherlands

CO2 fluxes for the Netherlands and surroundings are estimated for the year 2008, from concentration measurements at four towers, using an inverse model. The results are compared to direct CO2 flux measurements by aircraft, for 6 flight tracks over the Netherlands, flown multiple times in each season. We applied the Regional Atmospheric Mesoscale Modeling system (RAMS) coupled to a simple carbon fl

The wake of hovering flight in bats.

Hovering means stationary flight at zero net forward speed, which can be achieved by animals through muscle powered flapping flight. Small bats capable of hovering typically do so with a downstroke in an inclined stroke plane, and with an aerodynamically active outer wing during the upstroke. The magnitude and time history of aerodynamic forces should be reflected by vorticity shed into the wake.

A Model of GDNF Gene Therapy in Mice with 6-Hydroxydopamine Lesions: Time Course of Neurorestorative Effects and ERK1/2 Activation

Background: Glial cell line-derived neurotrophic factor (GDNF) is the most promising neurotrophin for restorative treatments in Parkinson's disease, but its biological effects are not completely understood. Objective: To define a model of GDNF gene therapy in the mouse, we studied the long-term effects of lentiviral GDNF delivery in mice with striatal 6-hydroxydopamine (6-OHDA) lesions. Methods: L

Size, structure and scaling relationships in glycogen from various sources investigated with asymmetrical flow field-flow fractionation and 1H NMR

In this paper we investigate the size, structure and scaling relationships in glycogen isolated from five different animal sources. For this purpose a versatile fractionation technique, asymmetrical flow field-flow fractionation (AsFlFFF), coupled to multi-angle light scattering, is utilized. For determination of the average degree of branching 1H NMR is utilized. The results give a detailed insig

U-Pb baddeleyite ages linking major Archean dyke swarms to volcanic-rift forming events in the Kaapvaal craton (South Africa), and a precise age for the Bushveld Complex

The Archean basement in the northeastern part of the Kaapvaal craton is intruded by a large number of mafic dykes, defining three major dyke swarms, which collectively appear to fan out from the Bushveld Complex. Herein we present U-Pb baddeleyite ages for two of these dyke swarms, the northwest trending Badplaas Dyke Swarm and the east-west trending Rykoppies Dyke Swarm, and infer their correlati

Reply to Comment on "U-Pb baddeleyite ages and geochemistry of dolerite dykes in the Bas-Draa inlier of the Anti-Atlas of Morocco: Newly identified 1380 Ma event in the West African Craton" by Andre Michard and Dominique Gasquet

Baddeleyite (ZrO2) is today recognized as the key mineral for dating the emplacement of mantle-derived igneous rocks, primarily gabbro and dolerite dykes and sills. The comment by Michard and Gasquet calls for a discussion on the significance of baddeleyite U-Pb TIMS dates of two dykes in the Bas-Draa inlier, dated at 1381 +/- 8 and 1384 +/- 6 Ma, presented in El Bahat et al. (2013-in this issue).