The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a signifi

Purpose – The purpose of this paper is to investigate what empirical evidence exists regarding benefits of information sharing in supply chains, and to identify potential gaps and opportunities in this research area. Design/methodology/approach – The authors conducted an in-depth, systematic literature review and multilevel analysis of 82 selected articles. In the analysis, the authors investiga

The Swedish missionary, Alma Johansson, witnessed the 1915 Armenian Genocide. Like many foreign missionaries and diplomats, Johansson was caught in the middle of the violence and was then forced to take on wider tasks and develop skills other than what she had primarily been sent out for. After the war, she developed new aid work among Armenian refugees in Thessaloniki. In order to understand Alma

Reinterventions seem to occur more frequently after endovascular aneurysm repair than after open surgical repair and are encountered in about 20% versus 10% of the cases, respectively. However, reinterventions following endovascular repair are predominantly endoluminal and early reinterventions are more frequent after open repair. The indications for reintervention after EVAR have changed over tim

High-resolution photoelectron spectra of the inner- shell levels of molecular oxygen have been measured using synchrotron radiation. The vibrational structure of the two magnetically-split core-shell components is analyzed based upon ab initio calculations. The ratio between the intensities of the two components was analyzed at several different ionization energies up to about 600 eV, and the same

A study related to the development and characterization of a new gene delivery system was performed. The approach consists in both the pre-condensation of plasmid DNA with an arginine-based cationic surfactant, arginine-N-lauroyl amide dihydrochloride (ALA), which was found not to be toxic, and the incorporation of the blood protein transferrin (Tf) into the formulations.Two cationic liposome form

The overall aim of the thesis was to study heart failure (HF) in an urban population, with reference to immigrant status, biological, life style and socioeconomic risk factors. The thesis is based on four papers. Paper I included inhabitants (N=114,917; aged 40-89 years) in the city of Malmö, Sweden, followed from November 1st, 1990 until December 31st, 2007. Paper II-IV used the population-based

Invariant mass distributions of jet pairs (dijets) produced in LHC proton-proton collisions at a centre-of-mass energy root s = 7 TeV have been studied using a data set corresponding to an integrated luminosity of 1.0 fb(-1) recorded in 2011 by ATLAS. Dijet masses up to similar to 4 TeV are observed in the data, and no evidence of resonance production over background is found. Limits are set at 95

Sepsis induced by intestinal perforation is a life-threatening illness and is a frequent cause of leukocyte-mediated lung injury. Although antimicrobial therapy has been the central clinical strategy for these patients, the survival rates in such patients are still very low because of their impaired host defense mechanisms. Therefore, control of amplified leukocyte recruitment in the lung may be a

A fully instrumented slice of the ATLAS central detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. in this paper, the response of the central calorimeters to pions with energies in the range between 3 and 9 GeV is presented. The linearity and the resolution of the combined calorimetry (electromagnetic and hadronic calorimeters) was measured and compared to

Homogeneous Charge Compression Ignition (HCCI) is a promising internal combustion engine concept. It holds promise of combining low emission levels with high efficiency. However, as ignition timing in HCCI operation lacks direct actuation and is highly sensitive to operating conditions and disturbances, robust closed-loop control is necessary. To facilitate control design and allow for porting of

This thesis is mainly concerned with the intersection between ideals and (maximal commutative) subrings of graded rings. The motivation for this investigation originates in the theory of C*-crossed product algebras associated to topological dynamical systems, where connections between intersection properties of ideals and maximal commutativity of certain subalgebras are well-known. In the last few

We present an electrode, based on structurally controlled nanowires, as a first step towards developing a useful nanostructured device for neurophysiological measurements in vivo. The sensing part of the electrode is made of a metal film deposited on top of an array of epitaxially grown gallium phosphide nanowires. We achieved the first functional testing of the nanowire-based electrode by perform

The work presented here is based on two papers, both pertaining to perturbation-based control strategies in industrial fed-batch fermentation processes. The first paper describes a new control strategy for avoiding overflow metabolism in the exponential growth phase of a fermentation, based on analysis of the frequency spectrum of the dissolved oxygen measurement following a periodic perturbation

To support learning, a sense of trust between student and teacher is required. This assumption is discussed in relation to three human conditions: the biological, the moral and the political. In the oral space of the classroom, teachers and students are dependent on these preconditions when asking: What is a we? What are we doing? What are we making? How emulation and the presence of trust play in