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Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis
Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role in the pathological process of PD are unclear. In the present study, we investigated the effects of
Characterization of rare germline variants in familial multiple myeloma
The patterns of family genetic risk scores for eleven major psychiatric and substance use disorders in a Swedish national sample
To clarify the structure of genetic risks for 11 major psychiatric disorders, we calculated, from morbidity risks for disorders in 1st–5th degree relatives controlling for cohabitation effects, in the Swedish population born between 1932 and 1995 (n = 5,830,014), the family genetic risk scores (FGRS) for major depression (MD), anxiety disorders (AD), obsessive-compulsive disorder (OCD), bipolar di
Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit
Background: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU). Methods: Retrospective study of 2434 patients (age
Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma : a study of younger patients from the MCL2 and MCL3 clinical trials
Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant c
Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting
PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO A
Exploring and comparing definitions of healthy vascular ageing in the population : characteristics and prospective cardiovascular risk
Different methods can be used to define healthy vascular ageing (HVA). In this prospective cohort study, we explored three different definitions in order to provide guidance for which to use. 2718 subjects were included from the Cardiovascular (CV) arm of the Malmö Diet Cancer Study (MDCS; median age 71.9 years, 62.2% females). Three different definitions of HVA were used: HVA-1 (
Delayed Collapse of the North Pacific Intermediate Water After the Glacial Termination
Carbon release from the North Pacific in glacial-interglacial cycles has been mainly linked to the North Pacific Intermediate Water (NPIW) formation and associated carbon/nutrient water upwelling and biological productivity changes. However, relationship between NPIW and atmospheric CO2 change in the early interglacial remains unclear. Here we report a high-resolution sediment record of NPIW evolu
Reconstructing Past Global Vegetation With Random Forest Machine Learning, Sacrificing the Dynamic Response for Robust Results
Vegetation is an important component in the Earth system, providing a direct link between the biosphere and atmosphere. As such, a representative vegetation pattern is needed to accurately simulate climate. We attempt to model global vegetation (biomes) with a data-driven approach, to test if this allows us to create robust global and regional vegetation patterns. This not only provides quantitati
Editorial preface
New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source
Historiskt perspektiv på hushållsnära tjänster
Updated physics performance of the ESSnuSB experiment
Instructing secondary school students in 'triplet' concept mapping for chemistry
A sociocultural perspective was utilized to explore if concept mapping using macroscopic, symbolic and submicroscopic aspects (often referred to as the ‘chemistry triplet’) can be used to promote development of expert knowledge in secondary school chemistry students by facilitating multilevel thinking. An additional aim was to explore the possibilities of using sociocultural theory to study the de
Distribution of heavy metals and related health risks through soil ingestion in rural areas of western Japan
The distribution of heavy metal concentrations and related human health risks were investigated for Shimabara City, Nagasaki Prefecture. The purpose was to clarify the potential for heavy metal contamination in an area already known to be affected by nitrate pollution. A total of 188 soil samples was collected at 47 sites. The heavy metal content of the soil was measured in laboratory using an X-r
Acute Stress in Health Workers during Two Consecutive EpidemicWaves of COVID-19
The COVID-19 pandemic has provoked generalized uncertainty around the world, with health workers experiencing anxiety, depression, burnout, insomnia, and stress. Although the effects of the pandemic on mental health may change as it evolves, the majority of reports have been web-based, cross-sectional studies. We performed a study assessing acute stress in frontline healthworkers during two consec