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Interfacial properties of lipid sponge-like nanoparticles and the role of stabilizer on particle structure and surface interactions

The advantage of using nonlamellar lipid liquid crystalline phases has been demonstrated in many applications, such as drug delivery, protein encapsulation and crystallisation. We have recently reported that a mixture of mono- and diglycerides is able to form sponge-like nanoparticles (L 3 -NPs) with large enough aqueous pores to encapsulate macromolecules such as proteins. Here we use small ang

The integrated palliative care outcome scale for patients with palliative care needs : Factors related to and experiences of the use in acute care settings

ObjectiveImplementation of patient-reported outcome measures for patients with palliative care needs is characterized by both enablers and barriers. The ways in which healthcare professionals experience the use of assessment tools is important. Our aims were to explore factors contributing to or hindering patients with palliative care needs in assessing their symptoms with the Integrated Palliativ

Randomized Trial of Sacroiliac Joint Arthrodesis Compared with Conservative Management for Chronic Low Back Pain Attributed to the Sacroiliac Joint

BACKGROUND: Sacroiliac joint pain is increasingly recognized as a cause of low back pain. We compared the safety and effectiveness of minimally invasive sacroiliac joint arthrodesis using triangular titanium implants and conservative management in patients with chronic sacroiliac joint pain. METHODS: This study was a prospective, multicenter randomized controlled trial of adults with chronic sacro

Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition

Purpose: Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Methods: Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Hom

Familial risks for common diseases : etiologic clues and guidance to gene identification

Familial clustering of a disease is a direct indicator of a possible heritable cause, provided that environmental sharing can be excluded. If the familial clustering is lacking, the likelihood of a heritable influence is also small. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the genome scan. The availability

Age-specific familial risks of psychotic disorders and schizophrenia : a nation-wide epidemiological study from Sweden

OBJECTIVE: This study analyzed men and women separately by age at hospital diagnosis of psychotic disorder or schizophrenia and by maternal or paternal disease after taking several possible confounders into account.METHODS: The Multigeneration Register, in which all men and women born in Sweden from 1932 onwards are registered together with their parents, was linked to hospital data. This yielded

Familial and second primary pancreatic cancers : a nationwide epidemiologic study from Sweden

Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for pancreatic cancer in 0- to 66-year-old

Synchrotron X-ray based characterization of technologically relevant III-V surfaces and nanostructures

Populärvetenskaplig sammanfattning:En studie publicerad av NASA:s Goddard Institute for Space Studies år 2019 visade att de genomsnittliga globala temperaturerna under de senaste fyra åren (2015-2018) var de högsta som någonsin registrerats i människans historia. Den nyheten passar väl in i de alarmerande prognoserna om global uppvärmning, och kräver snabba och radikala handlingar. Att studera “teInnovative design and materials are needed to satisfy the demand for efficient and scalable devices for electronic and opto-electronic applications, such as transistors, LEDs, and solar cells. Nanostructured III-V semiconductors are an appealing solution, combining the excellent functional properties of III-V materials with the flexibility typical of nanostructures, such as the nanowires (NWs) stu

The Fifteenth Data Release of the Sloan Digital Sky Surveys: First Release of MaNGA-derived Quantities, Data Visualization Tools, and Stellar Library

Twenty years have passed since first light for the Sloan Digital Sky Survey (SDSS). Here, we release data taken by the fourth phase of SDSS (SDSS-IV) across its first three years of operation (2014 July-2017 July). This is the third data release for SDSS-IV, and the 15th from SDSS (Data Release Fifteen; DR15). New data come from MaNGA - we release 4824 data cubes, as well as the first stellar spec

From Uniforms to Monitors : Persuasive design and targeting in international law

US counterinsurgency, thanks to geographically unbounded reach of drones, is characterized by extending wartime violence from battlefield to the monitor. In this article, we claim that the significance of the ‘new technologies’ of looking and targeting lies in their capacity to negotiate laws of war into the material world, thus determining the legitimacy of their expansive violence. Such negotiat

Ising Spins on a Dynamically Triangulated Random Surface

We study a model of random surfaces endowed with fermionic degrees of freedom. The critical parameters are estimated using a Monte Carlo simulation method, for the dimensionality d of the embedding space ranging from d=0 to d=10.

Studies of spin effects in charged Higgs boson production with an iterative discriminant analysis at the Tevatron and LHC

We report on detailed Monte Carlo comparisons of selection variables to separate tbH± signal events from the standard model tt background using an iterative discriminant analysis (IDA) method. While kinematic differences exist between the two processes whenever m_{Hpm≠}m_Wpm , the exploration of the spin difference between the charged Higgs and the W± gauge boson becomes crucial in the particularl