Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M

Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial. For this study, treatment efficacy was determined among 145 trial patients with morphological forms of acute myeloid leukemia as defined by the French-American-British classification. Leukemia-free survival was strongly i

ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are character

In this paper I discuss how a virtue ethic for the preservation of biodiversity may look like. The starting-point is the virtue ethic proposed by Celia Deane-Drummond. She suggests that the four cardinal virtues of prudence, justice, fortitude and temperance should form the basis of an ethic of nature. Of this four, prudence is the most fundamental. Moreover, Deane-Drummond states that the intelle

Artikeln diskuterar samspelet mellan jordarter, teknologi och "aktörer" och dessa olika faktorers betydelse för bebyggelseutvecklingen. I huvudsak diskuteras utvecklingen av landskapet och bebyggelsen kring Lund och Uppåkra i Skåne (Torna härad och delar av Bara härad). Exempel hämtas även från området kring Skälderviken och en del av Söderåsen (Björnekulla). Artikeln argumenterar för att forsknin

The Caloplaca citrina group in the Nordic countries, except Iceland, is analysed with regard to morphology, anatomy, ecology, and chemistry. Their genetic relationship is also analysed using the ITS ribosomal DNA gene. The results show that there are at least five species within what has been called C. citrina, of which four are closely related to one another and to several non-sorediate species.

NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways. Plants have a mitochondrial external NADPH oxidation pathway, which depends on Ca2+ and pH in vitro, but concentrations of Ca2+ needed are not known. We have determined the K0.5(Ca2+) of the external NADPH dehydrogenase from Solanum tuberosum mitoch

Popular Abstract in Swedish Personer som arbetar med joniserande strålning inom t.ex. sjukvård, kärnteknik och forskning använder så kallade dosimetrar för att registrera hur mycket joniserande strålning (vilken stråldos) personen blivit utsatt för under ett arbetspass eller en arbetsmånad. Den stråldos som en dosimeter mäter ger ett mått på risken för eventuella sena hälsoeffekter i form av en ökIn the event of a radiation accident, it is crucial to make rapid estimates of the absorbed dose received by both emergency workers, so-called first responders, and members of the public. Today, only personnel in rescue teams responding to nuclear emergencies have access to individual dosemeters. To make accurate assessments of the radiological consequences of an emergency situation, methods of re

Both ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) play an important role in nitrification in terrestrial environments. Most often AOA outnumber AOB, but the relative contribution of AOA and AOB to nitrification rates remains unclear. The aim of this experiment was to test the hypotheses that high nitrogen availability would favor AOB and result in high gross nitrification r

The aim of this thesis was to elucidate developments in epidemiology, clinical manifestations and complications in Chlamydia trachomatis (C.trachomatis) and Mycoplasma genitalium (M.genitalium) infection. In study I the frequencies of non-gonococcal salpingitis, gonococcal salpingitis and ectopic pregnancy (EP) were observed over a period of 28 years and correlated to the prevalence of Neisseria g

Thrombin generation is a key process that determines the extent of a hemostatic plug or a thrombotic process. The ensuing thrombin burst is crucial for the formation of a stable fibrin clot. During its active life, thrombin exerts a multitude of highly regulated actions on the blood and the vessel wall, among which is the clotting of fibrinogen. The inappropriate generation of thrombin may lead to

Family history of first and second-degree relatives is known to increase the risk for breast cancer. Less data are available on the risks between defined multiple affected close and distant relatives for which the reliability of data may be an issue. Data on affected males are sparse. These questions and the probable genetic models were addressed in this study by means of a nationwide Swedish Fami