Popular Abstract in Swedish Det övergripande målet med forskningsprojektet var att identifiera och karakterisera nya gener som liknar de kända sarkomförändrade generna FUS och EWS. De FUS eller EWS lika kandidatgenernas möjliga samband med tumörutveckling skulle sedan undersökas. Strategin var baserad på homologisökningar i de HUGO genererade EST databaserna för att hitta FUS-or EWS-liknande transUsing computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. The N-terminus of APRIL contains leucine-rich repeats. The mous

Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.

This paper presents an interactive tool which allows to study the problem of systems with delays. The developed tool provides several examples in order to compare PI control and Smith Predictor approaches for processes with delay. Robustness problems due to presence of model uncertainties can also be studied, as well as other control structures to face the different problems that the original Smit

A major problem when using software platforms to produce a variety of products relates to keeping a high quality of the platform throughout the development of the products. For a software platform development to be successful, it is essential to master the quality issues when managing and designing the platform. This thesis presents approaches that enable efficient use of the soft-ware platform

Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex att alla aspekter förmodligePopular Abstract in Swedish Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. Faktum är att dagens läkemedelsutveckling är så komplex

An important measure for climate change mitigation is reduction of energy use in buildings worldwide. To decrease the energy use of a building in a Nordic climate, increased thermal resistance of the building envelope is a suitable measure. Adding more insulation in combination with climate change may increase the risk of mold growth within the building envelope. This study evaluates hygrothermal

This paper presents some preliminary empirical reflexions about rural development in North East Argentina at the light of the recent socio-economic and political changes. The processes of decentralization that have taken place in the country during the decade of 1990 illustrate the complexity of rural development strategies at local level and the necessity to create policies to take into account t

Usage profiles and component reliability are two important factors in software system reliability estimation. To assess the sensitivity of a system’s reliability to the usage profile and to the reliability of its components, a Markov based system model is used. With the help of this model, the maximum sensitivity to one change or the statistical sensitivity to many independent changes can be estim

Video data and the tools for automated analysis have a great potential to be used in road traffic research, particularly road safety. In this project a video dataset is built and made public so that researchers can evaluate their algorithms on it. The dataset focuses on the traffic research applications (data from real research projects) and provides recordings of the traffic scenes, meta-data, ca

In a joint research project – Human Factors in Air Navigation Services, HUFA – between the Swedish Civil Aviation Administration and Lund University the focus is on human and organizational factors and safety in air traffic control. The Swedish Air Navigation Services (ANS) are undergoing major organizational changes in order to adapt to changing demands on efficiency and technical development in