Fibroblasts synthesize a variety of proteoglycans among which is a family of structurally related small proteoglycans, i.e. PG-S1 (biglycan) and PG-S2 (decorin). Fibromodulin, which is present in some tissues as a keratan sulfate proteoglycan, also belongs to this family. We have used primary fibroblasts from fetal skin and bovine sclera in culture to study the metabolism of proteoglycans. In part

Pump-probe experiments are commonly used at Free Electron Lasers (FEL) to elucidate the femtosecond dynamics of atoms, molecules, clusters, liquids and solids. Maximizing the signal-to-noise ratio of the measurements is often a primary need of the experiment, and the aggregation of repeated, rapid, scans of the pump-probe delay is preferable to a single long-lasting scan. The limited availability

The development of bleomycin-induced pulmonary fibrosis in rats was studied over a period of 21 d after an intratracheal instillation of bleomycin. The expression of three small proteoglycans (biglycan, decorin, and fibromodulin), collagen III and TGF-beta 1 was studied by RNA-transfer blot analysis. The proteoglycans were also studied by SDS-polyacrylamide gel electrophoresis and Western blots. T

We have studied the effects of cytokines, separately or in combination, on the production of proteoglycans in confluent cultures of fibroblasts. The cytokines used were the transforming growth factor-beta (TGF-beta), the platelet derived growth factor-AA (PDGF-AA), the platelet derived growth factor-BB (PDGF-BB) and the epidermal growth factor (EGF). Hyaluronan production increased in cells treate

We recently reported on the development of a 4-protein-based classifier (PDCD4, CGN, G3BP2, and OCIAD1) capable of predicting outcome to tamoxifen treatment in recurrent, estrogen-receptor-positive breast cancer based on high-resolution MS data. A precise and high-throughput assay to measure these proteins in a multiplexed, targeted fashion would be favorable to measure large numbers of patient sa

Following financialization, there has emerged an understanding of what it implies to be a shareholder based on the shareholder value perception. However, as this shareholder value perception spreads internationally, it clashes with traditional perceptions. In this paper, we apply the language developed by Bourdieu to a Swedish public debate on equal treatment of shareholders in connection with theFollowing financialization, there has emerged an understanding of what it implies to be a shareholder based on the shareholder value perception. However, as this shareholder value perception spreads internationally, it clashes with traditional perceptions. In this paper, we apply the language developed by Bourdieu to a Swedish public debate on equal treatment of shareholders in connection with the

A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks to the lightest neutralino (χ10) is reported. It uses an LHC proton-proton data set at a center-of-mass energy s=13 TeV with an integrated luminosity of 3.2 fb-1 collected with the ATLAS detector in 2015. The signal is searched for in events containing several energetic jets, of which at least

Few, if any, corporate governance related issues have been given as much research interest as ownership dispersion and ownership concentration of listed corporations: ‘Why is that some countries, such as the US and UK, has dispersed ownership of corporations listed there, while others, such as France and Germany, has concentrated ownership of corporations listed there?’. This is a question that ha

This essay discusses Houthi (rebel group in Yemen) slogan and tries to show the contrast between its form and content.

Family flocks of Marsh Tits Parus palustris in southern Sweden kept together until 11-15 d after fledging and stayed within the former territory of the parents. Mortality in the family flocks was low in one year (1.2-3.6%) but higher in another (18.6%). This level of mortality is compared with post-dispersal mortality in other species of tits. The occurrence of a parent-offspring conflict with reg

We developed a process-oriented model called NutsFor that simulates nutrient cycling of major cations (Ca, Mg, K, Al, NH4, Na) and anions (NO3, SO4, Cl) and the stable isotope tracers for each of the respective elements at the scale of an ecosystem (isotopic fractionation are not simulated). We tested the ability of NutsFor to reproduce major element and stable isotope tracer (26Mg and 44Ca) cycli

This paper provides insights into the behavior of academic patentees who choose to bypass in-house Technology Transfer Offices (TTOs). TTOs have gained favor in recent years as academic institutions have tried to increase commercialization of their inventions. Using a large sample of researchers at a leading German public research organisation (PRO), results show that patentees in physical and lif

The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The

Background The increasing prevalence of atrial fibrillation and novel therapeutic tools to prevent cardioembolic stroke has increased the need for risk markers. Objectives This study explored the relationship between the midregional sequence of pro-atrial natriuretic peptide (MR-proANP) levels with the risk of atrial fibrillation and stroke, and whether measurement of MR-proANP improves the predic