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Analysis and exploitation of resource efficiency potentials in industrial small and medium-sized enterprises – Experiences with the EDIT Value Tool in Central Europe

Material and energy costs represent about 50% of the operating costs incurred by European small and medium-sized enterprises (SMEs). Although the potential for resource efficiency improvements is high, the necessary awareness and human resource capacities to explore this potential are limited. Existing tools for exploration of resource efficiency improvement potentials have several shortcomings: t

Measurement of W boson angular distributions in events with high transverse momentum jets at s=8 TeV using the ATLAS detector

The W boson angular distribution in events with high transverse momentum jets is measured using data collected by the ATLAS experiment from proton–proton collisions at a centre-of-mass energy s=8 TeV at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb−1. The focus is on the contributions to W+jets processes from real W emission, which is achieved by studying events w

Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems

This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, bu

Hip fracture; an interruption that has consequences four months after a hip fracture. A qualitative study

Background: Effects following a hip fracture often lead to functional disabilities and increased dependence on others. Although persons sustaining a hip fracture constitute a heterogeneous group in Swedish health care, they tend to be treated as a homogenous one. Aim: The aim of this study was to reveal how previously healthy people, aged 65 years and older, described how they had adapted to daily

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Reading is based on the idea of Cultural Patterns, which happen to be the mostimportant tool of Cultural Criticism Forms. This means that reading has taken asystematic path to the Cultural Criticism that led to explosion of research in the most important Blogs in the Arab and Humanistic Heritage. Taking cue from this insight, researches argue that, the book of Kalila and Domna demonstrates the exi

Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays

Objective: To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. Methods: Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems,

Accurate prediction of X-ray pulse properties from a free-electron laser using machine learning

Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and temporal profile. Owing to the inherent fluctuations in free-electron lasers, this

The extracellular matrix - the under-recognized element in lung disease?

The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM) contains the main building blocks of both components. The ECM provides physical support and stability to the lung, and as such it has in the past been regarded as an inert structure. More recent research has provided novel insights revealing that the ECM is also a bioactive environment that orchestrates the cel

Sustainable insulation of historical wooden and stone buildings with lime-hemp

In this multidisciplinary project lime-hemp is studied as a thermal insulating material for the renovation of historic timber and brick buildings*). Focus is on buildings in the historic city of Visby on the Swedish island of Gotland in the Baltic sea. Many historic buildings in Visby have over the past decades been thermally insulated with materials such as mineral wools and polystyrene. Due to t

Changes in paraurethral connective tissue at menopause are counteracted by estrogen

OBJECTIVE: To study whether the transition to menopause is accompanied by changes in the paraurethral connective tissue and if these changes are modified by estrogen replacement therapy.STUDY DESIGN: Biopsies were obtained from the paraurethral tissue from 34 women; 12 menstruating, 14 postmenopausal without estrogen treatment, and 8 with estrogen treatment. Collagen concentration and collagen ext

Proliferation of cultured fibroblasts is inhibited by L-iduronate-containing glycosaminoglycans

We have modified a method (Gilles et al: Anal. Biochem., 159:109-113, 1986) for measuring cell number, that is based on the binding of crystal violet to cell nuclei and used it to assay effects of various glycosaminoglycans on growth of human lung fibroblasts. The procedure was modified by growing cells in microcultures (96 well microplates) and by measuring the amount of adsorbed dye using a micr

Quantitative proteomic analysis of microdissected breast cancer tissues : comparison of label-free and SILAC-based quantification with shotgun, directed, and targeted MS approaches

Quantitative proteomics plays an important role in validation of breast-cancer-related biomarkers. In this study, we systematically compared the performance of label-free quantification (LFQ) and SILAC with shotgun and directed methods for quantifying breast-cancer-related markers in microdissected tissues. We show that LFQ leads to slightly higher coefficient of variation (CV) for protein quantif

Ferritin heavy chain in triple negative breast cancer : a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response

Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients. Currently, it is not well understood how FTH1 contributes to an anti-tumor response. Here, we explored whether expression and cellular compartmentalization of FTH1

Privatization, vulnerability, and social responsibility : A comparative perspective

Taking a cross-cultural perspective, this book explores how privatization and globalization impact contemporary feminist and social justice approaches to public responsibility. Feminist legal theorists have long problematized divisions between the private and the political, an issue with growing importance in a time when the welfare state is under threat in many parts of the world and private mark

The technology shift thesis : Understanding long term growth and transformation in a regional system

The technology shift thesisUnderstanding long term growth and transformation in a regional systemAbstractIn this paper we examines the long run economic growth and productivity performance of regions and how this relates to different phases of structural change and economic adaptability in different part of a national regional system.Firstly, we suggest a theoretical ‘systemic’ approach for analyz

Human cervical ripening, an inflammatory process mediated by cytokines

An extensive remodelling process, referred to as cervical ripening, takes place in the cervical tissue during pregnancy and labour. It is recognized as softening and dilation of the cervical canal, and starts as a slow process during pregnancy, becoming rapid close to partum. In this study we focus on cytokines as possible mediators of this final remodelling. mRNA levels for interleukin (IL)-8, IL