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In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for th

A concentrating photovoltaic wall element, including Cu(In, Ga)Se-2-based modules, aluminum reflectors, and an insulation for building integration, has been developed and evaluated. The geometric concentration ratio of the system is about 3 x. However, the measured maximum electric power from the modules is only 1.9 times that of identical vertical modules without reflectors, due to optical losses

The fusion-evaporation reaction involving a 175 MeV S-36 beam and a Sn-124 target was performed, and the emitted gamma rays were observed with the Gammasphere spectrometer. Significant additions to the level scheme of Gd-152 were made in spite of the relative weakness of the alpha 4n exit channel, being only similar to 2% of the total fusion cross-section. The high-spin behavior of Gd-152 was comp

This thesis is about self-knowledge, self-regulation and self-control. All three of these terms are easily understandable, and apply to situations in our daily lives (like misjudging one’s own competence at retiling the bathroom floor, or feeling the anxiety and thrill of doing unsupervised work, or guiltily hitting the snooze-button for the fifth time, and missing half a day of school). The five

Transient cerebral ischemia following I to 2 hours of middle cerebral artery occlusion (MCAO) in the rat leads to infarction, which can be diminished by synaptic transmission modulators, implying aberrant cell signaling in the pathogenetic process. The authors report here changes in the levels of tyrosine phosphorylated proteins (PTyr) and calcium calmodulin kinase II (CaMKII) phosphorylation of T

Ibuprofen, a non-steroidal anti-inflammatory drug, exhibited antimicrobial activity against Candida albicans and non-albicans strains. At 10 mg/ml, ibuprofen showed a rapid cidal activity against exponential growth phase C. albicans, accompanied by rapid and extensive leakage of intracellular K+, permeation to propidium iodide, lysis of spheroplasts and severe membrane ultrastructural alterations.

Varactors for continuous frequency tuning are typically used in LC-oscillators. However, they have some drawbacks for large tuning-ranges, such as high tuning sensitivity causing high sensitivity to noise and disturbances on the control voltage. Furthermore, large metal-oxide-semiconductor (MOS) varactors have high conversion of harmless amplitude noise into harmful phase noise. To reduce these pr

Regular octahedral coordination has been reported for some copper(II) complexes in the solid state on the basis of crystallographic studies, e.g. hexaaquacopper(II) bromate, [Cu(OH2)(6)](BrO3)(2). hexaaquacopper(II) hexafluorosilicate, [Cu(OH2)(6)]Si-6, and hexakis(pyridine-1-oxide)copper(II) perchlorate. [Cu(ONC5H5)(6)](ClO4)(2). These results are not consistent with the elongated octahedral conf

Popular Abstract in Swedish Polyomavirus är en familj av små DNA-virus som har onkogena egenskaper i försöksdjur i celler in vitro. De humana polyomavirusen BK virus (BKV) och JC virus (JCV) infekterar en stor del av befolkningen. Ungefär 70-80 % av vuxna är seropositiva, har antikroppar mot BKV och JCV. Primär infektion inträffar oftast under barndomen och är ofta subklinisk. Efter primära infektThe human polyomaviruses BKV and JCV are endemic and infect > 70% of population worldwide. Primary infections occur during childhood and are largely subclinical. Following primary infection, both viruses persist as latent infections in the kidneys and B lymphocytes. Under conditions of severe immunosuppression like leukaemia, organ transplantation and AIDS, the viruses can reactivate and cause dis

OBJECTIVE: To investigate possible associations between use of cardiovascular drugs and suicide. DESIGN: Cross sectional ecological study based on rates of use of eight cardiovascular drug groups by outpatients. A population based cohort study including users of drugs to control hypertension. SUBJECTS: The ecological study included 152 of Sweden's 284 municipalities. The cohort study included all

For many years, newborn infants admitted to neonatal intensive care units have had routine electrocardiography and been monitored for respiratory rate, heart rate, oxygen saturation, and blood pressure. Only recently has it also been considered important to monitor brain function using continuous electroencephalography. The role of cerebral function monitoring in sick full term and preterm infants

A girl with polydactyly has had respiratory tract problems, including atelectasis, since birth. She has a high arched palate, a tongue hamartoma and dysmorphic face. Electron microscopy of nasal and bronchial brush biopsies repeatedly revealed centriole/basal body disarray and extreme sparseness of cilia. At the age of 2 years and 11 months, she displayed retardation of both motor and mental skill

The three dimensional structures of human prostate specific antigen (PSA) and glandular kallikrein (hGK) were modeled based on porcine pancreatic kallikrein A. High sequence similarity and conserved framework of serine proteases enabled accurate modeling. The catalytic site region consisting of catalytic triad, residues forming oxyanion hole and main-chain substrate binding residues were conserved