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Bladder cancer remains a prevalent and deadly cancer form worldwide. While immunotherapy has yielded significant progress, additional therapeutic strategies are needed to improve the response in bladder cancer patients. A novel immune cell target, referred to as “protein X”, has previously been identified in Lundberg’s lab. Antibodies developed against protein X were provided to us, with the aim o
The global adoption of International Financial Reporting Standards (IFRS), developed by the International Accounting Standards Board (IASB), aims to enhance financial reporting transparency, comparability, and reliability by standardizing accounting practices and limiting managerial discretion. While IFRS has improved accounting quality in many regions, its impact depends on prior local GAAP quali
Warming due to global climate change has led to various natural anomalies, such as increases in forest fires, water level rise and droughts. A region being affected heavily by climate change is the Colorado River Basin, having an arid, semi-arid climate with the Colorado Mountain snowmelt supplying Colorado river, which flows throughout the basin, accumulating water in Lake Mead Reservoir. The Bas
Phosphorylation is one of the main post-translational modifications (PTMs) regulating protein function, where kinases reversibly add phosphate groups to specific amino acid residues (phosphosites). Kinase activity is altered in breast cancer (BC), resulting in loss of regulation of several cellular processes. Phosphoproteomics emerges as a powerful approach for profiling samples at phosphosite lev
The current Swedish Social Services Act is based on the law that entered into force in 1982. The society has since then extensively changed, and new social issues have arisen. Therefore, the Swedish government handed over a proposition on the 23rd of January 2025, suggesting the implementation of a new law for social services. The purpose of this study has been to investigate perceptions of and pr
This study aimed to explore young people's perceptions of healthy and destructive romantic relationships, how they perceive the influence of different sources of knowledge, and how they construct and normalize violence regarding their relationships. The method chosen for this study was qualitative focus group interviews with students in grades one and three at a high school in Scania, involvin
This study aims to deepen the understanding of how different aspects of Arts on Prescription Finsam Mittskåne lead to improved well-being among the participants. The method is qualitative interviews with previous participants in Arts on Prescription and observations of a current group during their activities. The group aspect, lack of pressure, and resonance in Arts on Prescription were analysed u
This thesis investigates the concept of synthetic inertia, especially in relation to wind power. Further, the ability of wind power to contribute with frequency regulating ancillary services, through synthetic inertia, to the power system is examined. Synthetic inertia is defined as a concept that encompasses a variety of techniques, production methods, and control strategies that provide the grid
The bulk of Norwegian offshore oil and gas platforms are self-sustained with energy, burning a portion of the extracted gas in turbines to power production. Replacing this energy with electricity from renewables – electrifying – has been put forward as a way to quickly slash domestic emissions. This, all while retaining and expanding fossil fuel production, whose lion’s share of emissions stem not
Unsupervised learning techniques are gaining traction in industrial applications due to the increasing volume of unlabeled data in manufacturing environments. This study explores whether such methods can help address two inefficiencies identified in a cheese production process: Uncovering hidden operational modes related to machine performance through clustering and detecting one-off anomalies tha
This study explores how Olympic legacy is leveraged as a branding tool by the International Olympic Committee and host nations, applying Mats Urde's Brand Identity Matrix to the Opening Ceremonies of Paris 2024, Rio 2016, and Beijing 2008. We conduct a qualitative analysis of secondary data to uncover key alignments and misalignments in legacy communication. We develop a Dual Mission Framework
This thesis investigates the creation and assessment of a Federated Learning (FL) system which improves real-time object recognition for visually-impaired applications through embedded AI and edge computing. The research divides into two distinct sections. The initial phase of the FL validation used a CNN trained on the MNIST dataset to allow controlled testing of model updates and communication b
Detta reflekterande arbete utforskar konsten att tillverka fagottblad ur ett repertoarinriktat perspektiv, I ett förinspelat format som gör det möjligt för tittaren att fördjupa video- upplevelsen med en avslutande text som nämner de referenser och resurser från vilka det detaljerade hantverket I videon hämtas och jämförs. Detta forskningsprojekt syftar till att ge praktiska insikter i hur bladetsThis reflective work explores the art of bassoon reed making from a repertoire-oriented perspective, in a pre-recorded format that allows the viewer to deepen the video experience with a conclusion text that mentions the references and resources from which the detailed crafting in the video is issued and contrasted. This research project aims to provide practical insights into how reed constructio
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a key regulator of metabolism, but how its structural dynamics control allosteric signaling remains unclear. To investigate this, we performed molecular dynamics simulations of PPAR-gamma and applied time-lagged independent component analysis to reduce the dimensionality of the data. Microstates were identified using K-means clusteri
Approximately 80% of agricultural land in the world is comprised of annual crops which have a life span of only one year. Research has shown that these crops are unsustainable because of these short life spans. Soil erosion, nutrient leaching, and losses of soil carbon are just a few problems caused by annual monocultures. Additionally, with the changing climate, these cropping methods are both vu
This thesis examines how Kenyan Generation Z activists used social media, particularly X (Twitter) as a tool for resistance, mobilization, and political discourse during the 2024 protests against the Finance Bill. Drawing on a postcolonial Global Studies framework, the study situates Kenya’s digital protests within broader global systems of inequality, colonial legacy, and youth disenfranchisement
Equity Real Estate Investment Trusts (REITs) face persistent challenges in performance tracking and financial reporting due to fragmented data systems, manual processes, and delayed access to critical insights. This thesis examines the use of Power BI, a business intelligence (BI) tool, as a means to modernize reporting practices and support data-driven decision-making within REITs. Drawing on use
Background: Type 2 diabetes (T2D) and dementia represent a growing dual burden in aging populations. These conditions share pathophysiological mechanisms that may create a self-reinforcing cycle in which cognitive impairment affects diabetes management, a crucial factor for preventing complications. Despite Sweden's comprehensive care, there is limited longitudinal evidence on how cognitive
Work passion is increasingly regarded as essential for both organizational success and individual well-being, yet its antecedents and underlying mechanisms remain underexplored. This study investigates how workplace factors (job autonomy, procedural justice, and leader– member exchange) relate to harmonious and obsessive passion through the mediating role of psychological need satisfaction. A cros
The design and development of drugs which can permeate the blood brain barrier (BBB) for the treatment of hard-to-treat central nervous system (CNS) diseases is a critical and prevalent challenge in medicinal chemistry. Such diseases include Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) - both chronic and progressive neurodegenerative disorders affecting the brain. Galectin-3 (gal-3) is a
