Obesity and type 2 diabetes are increasing at alarming rates worldwide, presenting significant public health challenges. A key player in these conditions is GLUT4, a protein that helps transports glucose into cells in response to insulin. Proper function of GLUT4 is crucial for maintaining healthy blood sugar levels and overall metabolic health.To address this, in this thesis I have explored the m

This thesis presents a comprehensive powertrain optimization methodology that effectively captures the key design trade-offs impacting vehicle performance, both within individual components and across them. The method relies on detailed performance and cost models for all the powertrain components considered, including the electrical machine, power electronics converter, and mechanical transmissio

This dissertation investigates the intricate dynamics between international capital flows, banking instability, and central bank policies in Sweden from 1877 to 1939, providing insights into the connections between external monetary shocks and domestic financial stability. While international capital can drive economic growth, it also introduces significant risks, particularly for smaller, open ec

In this letter, a compact broadband high-efficiency microwave rectifier is presented for powering implantable medical devices located deeply in the human body. By utilizing a modified real frequency technique and an RF step-up transformer at the input matching network, the proposed rectifier has a measured conversion efficiency ( η) exceeding 50% over a 62% fractional bandwidth from 900 to 1700 MH

This paper addresses attitude synchronization problems for systems of multiple rigid-body agents with directed interconnection topologies. Two scenarios which differ in available information are considered. In the first scenario the agents can obtain their rotations and angular velocities relative to an inertial reference frame and transmit these information to their neighbors, while in the second

The "Likhall"bed is a rare case of a single-age zircon population from a carbonate rock, which in this case is contextualised with remarkable biotic and environmental changes and with meteorite bombardment of Earth after an asteroid breakup in space. Published high-precision chemical abrasion isotope dilution thermal ionisation mass spectrometry (CA-ID-TIMS) U-Pb age estimates disagree on the typi

Objectives: Bacteremia is an acute severe infection with high mortality. Changes in healthcare services and coinfections with SARS-CoV-2 may have affected the mortality for bacteremia during the COVID-19 pandemic, which has been reported for other major diseases. In this study we examine the all-cause bacteremia mortality amidst the COVID-19 pandemic. Methods: A population-based cohort study compr

Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are based on simplified regression models modeling the conditional mean of a phenotype as a linear function of genotype. We draw attention here to an alternative, lesser known approach, namely quantile regression that natural

A popular uprising in 2014, led to a revolution that overthrew the sitting President of Burkina Faso. We investigate if individuals' risk attitudes changed due to this revolution. We examine this impact by the main determinants of risk attitudes: gender, age and level of education. The analysis is based on unique panel survey data, allowing us to track the changes in the risk attitudes of the sameA popular uprising in 2014, led to a revolution that overthrew the sitting President of Burkina Faso. We investigate if individuals' risk attitudes changed due to this revolution. We examine this impact by the main determinants of risk attitudes: gender, age and level of education. The analysis is based on unique panel survey data, allowing us to track the changes in the risk attitudes of the same

Obesity and Type 2 diabetes (T2D) are known to exacerbate cerebral injury caused by stroke. Metabolomics can provide signatures of metabolic disease, and now we explored whether the analysis of plasma metabolites carries biomarkers of how obesity and T2D impact post-stroke recovery. Male mice were fed a high-fat diet (HFD) for 10 months leading to development of obesity with T2D or a standard diet

När det internationella samfundet under ”superutvecklingsåret” 2015 åtog sig uppgiften att utrota fattigdom och hunger var det under löftet ”Leave no one behind”, dvs att alla överallt ska inkluderas och få ta del av utvecklingens framsteg. Hur kan ett sådant löfte bli verklighet och vilka utmaningar ligger framför oss? Denna översiktsartikel syftar till att ta itu med dessa frågor genom att fokus

A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,0

Manipulating the light polarization properties of gold nanoparticle aggregates can facilitate their applications in sensing and imaging. However, control of the intrinsic light polarization on demand at the nanoscale is hindered by the lack of a fundamental understanding of the structure-dependent plasmon coupling in the aggregates. Here, the polarization properties of intrinsic photoluminescence

In the period between 5,300 and 4,900 calibrated years before present (cal. bp), populations across large parts of Europe underwent a period of demographic decline1,2. However, the cause of this so-called Neolithic decline is still debated. Some argue for an agricultural crisis resulting in the decline3, others for the spread of an early form of plague4. Here we use population-scale ancient genomi

In this paper, we solve an inverse resonance problem for the half-solid with vanishing stresses on the surface: Lamb's problem. Using a semiclassical approach, we are able to simplify this three-dimensional problem of the elastic wave equation for the half-solid as a Schr\"odinger equation with Robin boundary conditions on the half-line. We obtain asymptotic values on the number and the location o

IMPORTANCE Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality. OBJECTIVE To study the association between sodium intake and incident atrial fibrillation (AF). DESIGN, SETTING, AND PARTICIPANTS This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global End

The aim of this study was to identify a Bifidobacterium strain that improves the performance of Limosilactobacillus reuteri DSM 17938. Initial tests showed that Bifidobacterium longum subsp. longum strains boosted the growth of DSM 17938 during in vivo-like conditions. Further characterization revealed that one of the strains, BG-L47, had better bile and acid tolerance compared to BG-L48, as well

ChatGPT has gained increased attention as an artificial intelligence (AI)-based tool in the field of tourism and hospitality education in recent years. This study investigates the impact of perceived ease of use, perceived usefulness and authenticity on student attitude and intention to use ChatGPT by incorporating the concept of authenticity into the technology acceptance model (TAM) theoretical