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Background: Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early stage of Alzheimer’s disease (AD). In this study, we elucidate the utility of combination of plasma amyloid-β (Aβ)-related biomarkers and tau phosphorylated at threonine 217 (p-tau2
The apparently contradictory co-existence of high levels of gender equality and intimate partner violence against women (IPVAW) found in Nordic countries has been termed the Nordic Paradox. The aim of this study was to examine how the Nordic Paradox is discussed and explained by Spanish professionals working in the IPVAW field. Five focus groups (n = 19) and interviews with key informants (n = 10)
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients. In this s
Background: Assessments of arm motor function are usually based on clinical examinations or self-reported rating scales. Wrist-worn accelerometers can be a good complement to measure movement patterns after stroke. Currently there is limited knowledge of how accelerometry correlate to clinically used scales. The purpose of this study was therefore to evaluate the relationship between intermittent
Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkin
The freedoms of thought (and opinion) are considered as absolute rights within the human rights law framework. Though found in separate provisions within the human rights instruments, the content and contours of these freedoms are largely interchangeable and overlap. The freedom of thought (and opinion) consists of three elements, namely, that thoughts and opinions can be kept private; thoughts ca
Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These structures have been suggested to develop through chromothripsis, followed by circularization and breakage-fusion-bridge (BFB) cycles. To test this hypothesis, we compared WDLSs with Chr12 amplification in rod-shaped chromosomes with WDLSs with ri
Stellar mergers and accretion events have been crucial in shaping the evolution of the Milky Way (MW). These events have been dynamically identified and chemically characterized using red giants and main-sequence stars. RR Lyrae (RRL) variables can play a crucial role in tracing the early formation of the MW since they are ubiquitous, old (t ≥ 10 Gyr) low-mass stars and accurate distance indicator
Freshwater lakes globally are witnessing an escalation in the frequency and intensity of cyanobacterial harmful blooms. However, underlying factors influencing the succession or coexistence of cyanobacteria, especially filamentous ones, remain poorly understood. Lake Honghu, a Ramsar Wetland of International Importance with degrading aquatic ecological quality, served as a case study to elucidate
The xylonate was bioproduced directly from lignocellulosic residues, and the application properties of crude xylonate powder were investigated with a promising potential as a bio-based concrete water reducer. The overall integrated process was evaluated on the view of mass balance and techno-economic analysis using Aspen Plus modeling. 56 g/L of calcium xylonate (XA-Ca) can be obtained within 8 h
We propose a framework to account for neutrino masses at the two-loop level. This mechanism introduces new scalars and Majorana fermions to the Standard Model. It assumes the existence of a global U(1)×Z2 symmetry which after partial breaking provides the stability of the dark matter candidates of the theory. The rich structure of the potential allows for the possibility of first-order phase trans
Dissolved organic matter (DOM) plays a central role in soil carbon (C) dynamics, serving as both a substrate for microbial decomposers and a source of material stabilised via physical protection in molecular aggregates and associations with mineral particles. It is well established that soil microorganisms play a key role in mineral-associated C aggregates; however, their impacts on molecular aggr
This paper focuses on the intersection of social dynamics, knowledge production, and the implementation of identity features in robotic platforms. Concentrating on the concept of epistemic injustice, particularly in the context of trust, the study highlights the potential for justified distrust based on experienced injustice. The incorporation of social identity features, such as gender, signals g
Consumers are increasingly asked to “empty out their closets,” to “declutter” or in other ways detach themselves from the textile surplus of their wardrobes. In this article, fashion is examined as a process of detachment. Building on ethnographic wardrobe interviews, wardrobe clearances and group discussions with consumers, detachment is viewed as a fundamental, yet underexamined, process of fash
Social media is abound with women writing about consumption goods and practices associated with femininity and heterosexual nuclear family life, such as being married, dressing, cooking and home decoration. This article examines how the housewife ideal can be an attractive identity in the 2010s and, drawing on the post-humanist performativity by Karen Barad (2007), it maps the material-discursive
As the world changes, so do perceptions of luxury. Consequently, the luxury industry’s efforts to capture the consumer’s imagination also change. Traditionally, the visual language that is used to market perfumes builds on a heterosexual logic; by objectifying and subordinating the feminine subject and portraying ‘her’ as desirable to an internalized male gaze. However, if you want the best money
Mass-produced consumer packages are everyday objects that almost go unnoticed. However, by claiming things such as the essence of femininity or masculinity, they affect us and are co-creators of our reality. Based on visual ethnography, this article traces the representation of gender on mass-produced packaging during a time when male privilege is being challenged and female visual objectification
Bör vi sträva efter att älska vårt jobb? Har det rent av blivit en förväntan som många arbetsgivare har? På en tuff arbetsmarknad som alltmer kräver individens hängivenhet och engagemang uppstår en problematik i vem det är som har makten över de personliga valen.I Att älska sitt jobb för etnologen Magdalena Petersson McIntyre ett angeläget samtal om passion och styrningen av den. Om känslor betrak
Konsumtionens roll i en accelererande konsumtionskultur berör både människor och samhällets organisering, men har inte alltid fått den uppmärksamhet den förtjänar. En person som verkat för att utveckla forskning om konsumtionskultur i Sverige är professor em. Helene Brembeck vars forskning spänner över många områden: barndom, fredagsmys, vardagsliv, praktiker relaterade till mat och ätande, kommer
