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A monoclonal neutralizing IgA antibody reduces phagocytosis of SARS-CoV-2 spike beads

Från IgG till IgA: En omvandling som hämmade fagocytos av SARS-CoV-2 spike-kulor Sedan slutet av 2019 har COVID-19 pandemin orskat förödande konskekvenser för både människa och hälsa, med miljontals döda och en djup socioekonimsk inverkan. Boven bakom denna pandemi är viruset Severe Acute Respiratory Syndrome Corona Virus 2, eller SARS-CoV-2. Ett av våra viktigaste skydd mot SARS-CoV-2 är antikro

Scams and Counter-Scams: An Investigation Into the Deception Tactics of Phone Scammers and Scambaiters

The purpose of this thesis is to investigate the techniques that scammers and scambaiters use in phone conversations to deceive each other and accomplish their respective goals. Seeing how the number of people losing money to scams continues to rise every year, there is an urgent need for more research to raise awareness of common scam tactics. It is also highly sociologically relevant to gain an

Characteristics of fatal and serious cyclist collisions in Ireland: Analysis of police investigation files

Cycling has been increasing in popularity in many countries, including the Republic of Ireland. Concurrently, the modal share of cyclist casualties has been increasing. However, there has been limited analysis of the pre-crash manoeuvres and impact configurations of cyclist collisions in Ireland, which inhibits the prioritization of engineering solutions. Accordingly, in this study, police investi

KinePose: A temporally optimized inverse kinematics technique for 6DOF human pose estimation with biomechanical constraints

Computer vision/deep learning-based 3D human pose estimation methods aim to localize human joints from images and videos. Pose representation is normally limited to 3D joint positional/translational degrees of freedom (3DOFs), however, a further three rotational DOFs (6DOFs) are required for many potential biomechanical applications. Positional DOFs are insufficient to analytically solve for joint

Evapotranspiration in Semi-Arid Climate : Remote Sensing vs. Soil Water Simulation

Estimating crop evapotranspiration (ETa) is an important requirement for a rational assessment and management of water resources. The various remote sensing products allow the determination of crops’ biophysical variables integrated in the evaluation of ETa by using surface energy balance (SEB) models. This study compares ETa estimated by the simplified surface energy balance index (S-SEBI) using

Energetics of Microwaves Probed by Double Quantum Dot Absorption

We explore the energetics of microwaves interacting with a double quantum dot photodiode and show wave-particle aspects in photon-assisted tunneling. The experiments show that the single-photon energy sets the relevant absorption energy in a weak-drive limit, which contrasts the strong-drive limit where the wave amplitude determines the relevant-energy scale and opens up microwave-induced bias tri

Ultrathin carbon film electrodes from vacuum-carbonised cellulose nanofibril composite

A novel way to produce ultrathin transparent carbon layers on tin-doped indium oxide (ITO) substrates is developed. The ITO surface is coated with cellulose nanofibrils (from sisal) via layer-by-layer electrostatic binding with poly(diallyldimethylammonium chloride) or PDDAC acting as the binder. The cellulose nanofibril-PDDAC composite film is then vacuum-carbonised at 5008C. The resulting carbon

Automatisk vårdnadsöverflyttning vid dödligt våld inom familjen och dess förenlighet med artikel 8 i Europakonventionen

I betänkandet Se barnet och propositionen Ett stärkt barnrättsperspektiv i vårdnadstvister behandlade utredaren respektive regeringen bland annat ett förslag om att införa en bestämmelse om automatisk vårdnadsöverflyttning vid dödligt våld inom familjen. Enligt utredaren och regeringen är det bäst för barnet att den förälder som har dödat barnets andra förälder inte är vårdnadshavare eller har någIn preparatory work, the research officer and the government have considered a proposal about compulsory transfer of custody in the case of deadly violence within the family. According to the research officer and the government, it is in the best interests of the child that the parent who has killed the other parent of the child no longer is the legal guardian or has any contact with the child in

How do students perceive usability and usefulness of the Eclipse Integrated Development Environment? A survey study on students’ perspectives at Lund University.

This study examines the factors regarding the perceived usability and usefulness of the Eclipse IDE and how this influences students' perceptions of the Eclipse IDE in the context of education. The theoretical framework of the study is the Technology Acceptance Model (TAM). The theoretical framework Modes of Interaction is introduced to further explain external factors. The external factors in

Older women with a low pension, living in Sweden: Strategies to age in place and thoughts about future housing

Financial security influences good quality housing, health, and longevity, but few recent studies of the financial aspects of aging in place have been published. We explored strategies used to age in place and thoughts about future housing among women aged 65 and older living with a low pension in Sweden. We conducted semi-structured qualitative interviews with 13 women aged 65 and older with a lo

Generalized precursor prediction boosts identification rates and accuracy in mass spectrometry based proteomics

Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers. However, the large search space required to identify novel biomarkers from the plasma proteome can introduce a high rate of false positives that compromise the accuracy of false discovery rates (FDR) using existing validation methods. We developed a

Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer with high heterogeneity and poor therapeutic responses to standard treatments. The use of herbal medicine for treatment of TNBC is gaining in popularity worldwide due to their better anti-tumor efficacy and less side effects compared to chemotherapy agents. Previous studies have shown that crocin, a natural carotenoid

Peripheral arterial disease (PAD) – A challenging manifestation of atherosclerosis

The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and signs may show great variation. As all grades of PAD are linked to both an increased risk for cardiovascular complications and adverse limb events, awareness of the condition and knowledge about diagnostic measures, prevention and treatment is crucial. This article presents in a condensed form information on P

Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic castration-sensitive prostate cancer

Background: The first interim analysis of the phase III, randomized, double-blind, placebo-controlled, multinational TITAN study demonstrated improved overall survival (OS) and radiographic progression-free survival (rPFS) with apalutamide added to ongoing androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer. The final analysis confirmed improvement i

Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause progeroid disease remains unclear. Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display nuclear DNA damage, cell cycle arrest, aberrant mitoses, and cellular senescence in the affected orga

The role of manual gestures in second language comprehension : A simultaneous interpreting experiment

Manual gestures and speech form a single integrated system during nativelanguage comprehension. However, it remains unclear whether this hold forsecond language (L2) comprehension, more specifically for simultaneousinterpreting (SI), which involves comprehension in one language and simultaneousproduction in another. In a combined mismatch and priming paradigm,we presented Swedish speakers fluent i

A Comparative Lifecycle Impact Analysis: Assessing Global Warming Potential of Newly Manufactured and Reused Bricks for Building Construction in Sweden

The aim of the study is to compare the environmental performance in terms of Global Warming Potential (GWP), for reused bricks and newly manufactured bricks used in Swedish Construction Industry. The objective of the study was to compile and conduct Life Cycle Assessment (LCA), in terms of GWP, of newly manufactured and reused clay façade bricks used in Sweden. Cradle-to-cradle lifecycle impact of

Att lita blint - En kvalitativ intervjustudie av förtroendet för Säkerhetspolisen

Följande uppsats undersöker det komplexa förhållandet mellan den svenska allmänhetens förtroende för Säkerhetspolisen och myndighetens mycket hemliga arbete. Med hjälp av kvalitativa intervjuer syftar uppsatsen till att besvara frågor om hur svenskarnas förtroende för Säkerhetspolisen kan förstås och vilken roll sekretessen spelar för deras förtroende. Vidare, med utgångspunkt i tidigare forskning