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Transoral robotic surgery in the management of head and neck squamous cell cancer with unknown primary

Background: Transoral robotic surgery (TORS) assisted base of the tongue (BOT) resection has been suggested as part of the work-up for head and neck squamous cell cancer with unknown primary (HNSCC-CUP). Success rates vary with regard to identification of primary BOT lesions, and cases with likely such lesions appear to be included in previous reports. Objectives: To analyse the possible benefits

Phenotypic antibody discovery and mining of complex antibody libraries

Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. A strategy to achieve this is to use phage display antibody libraries and selection on

Tourists' place-making performances through music

Traditionally tourists are treated as passive media consumers but this chapter departs from a performance perspective emphasizing tourists’ active role. This chapter deals with how popular music affects tourists’ experiences in destinations by exploring the performance of place-making practices by tourists as they engage with music. The performance perspective is complemented with a ritual perspec

Towards a Circular Economy with Environmental Product Policy : Considering dynamics in closing and slowing material loops for lighting products

A Circular Economy (CE) can help to achieve the sustainable development goal of responsible consumption and production. Product policies, in turn, can support CE objectives by promoting reuse of products, recycling of materials, and providing ecodesign incentives for more durable products. This thesis examined the role of product policies in meeting CE objectives in the EU, with specific focus on

A quick test of cognitive speed can predict development of dementia in Parkinson’s disease

Parkinson’s disease (PD) patients frequently develop cognitive impairment. There is a need for brief clinical assessments identifying PD patients at high risk of progressing to dementia. In this study, we look into predicting dementia in PD and underlying structural and functional correlates to cognitive decline in PD. We included 175 patients with PD, 30 with PD dementia, 51 neurologically health

In Pursuit of a Stable Stabilization Policy in Sweden. From the Gold Standard to Inflation Targeting and Beyond

In a historical perspective, the stabilization policy regime in Sweden is in a state of constant change, affected by economic crises, international impulses, domestic politics, and developments in macroeconomic theory. Economists have been deeply involved in this process. The current framework for monetary and fiscal policy, with an independent central bank focusing on inflation targeting, and a r

Suppression-induced forgetting diminishes following a delay of either sleep or wake

We investigated the duration of suppression-induced forgetting (SIF), and the extent to which retrieval suppression differs between negative and neutral memories. We further examined if SIF was differently affected by sleep versus wake during the delay interval between retrieval suppression and re-test. Fifty participants first learned to associate neutral words with either neutral or negative ima

Is Innovation out of Control? An Explorative Study in Management Control Systems and the Business Model of Innovation

The aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and thThe aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and th

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children : The TEDDY study

Objective: Higher gluten intake, frequent gastrointestinal infections and adenovirus, enterovirus, rotavirus and reovirus have been proposed as environmental triggers for coeliac disease. However, it is not known whether an interaction exists between the ingested gluten amount and viral exposures in the development of coeliac disease. This study investigated whether distinct viral exposures alone

Detection and clinical manifestation of placental malaria in southern Ghana

BACKGROUND: Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections in pregnant women is not well established.METHODS: In a cross-sectional, year-round study among 839 delivering women in Agogo, Ghana, P. falciparum was screened for in both, peripheral and placental blood samp

Effects of dextran-linked chloromercuribenzoic acid on insulin release from microdissected pancreatic islets

Insulin release in response to dextran-linked p-chloromercuribenzoic acid was studied in microdissected pancreatic islets of non-inbred ob/ob-mice. No contamination of the dextran-linked mercurial with free chloromercuribenzoic acid was detected before or after the incubation with islets. In comparison with free mercurial, of the same thiol-blocking activity, the dextran-linked compound had a weak

Mobilizing Pity: Iranian Women on the Long Road to Azadi Stadium

This article examines the politics of pity deployed by Iranian activists against the football stadium ban imposed on Iranian women and its impact on individual and collective histories of suffering and struggle of Iran's women in the pursuit of attaining citizenship

Population centroids of the world administrative units from nighttime lights 1992-2013

Knowledge about the past, current and future distribution of the human population is fundamental for tackling many global challenges. Censuses are used to collect information about population within a specified spatial unit. The spatial units are usually arbitrarily defined and their numbers, size and shape tend to change over time. These issues make comparisons between areas and countries difficu