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Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stability (DARTS) and mass spectrometry imaging (MSI) without modifying or labeling natural compounds. Thro

Lung cancer accounts for 1.6 million deaths per year worldwide. The majority of patients are diagnosed at advanced stages of the disease and often present with metastasis. Thus, the 5-year survival rate of lung cancer remains around 15%. Early diagnosis of lung cancer allows for better control of the disease with 5-year survival rates up to around 70%. Chest radiography is the most common techniqu

To overcome the large discrepancy in speed between computational devices and that of contemporary large capacity non-volatile memory (NVM) technologies, resistive random access memory (RRAM) technologies are seen as promising candidates, offering speed/energy improvements in several orders of magnitude while being 3D integration compatible [1]. Indium-Tin-Oxide (ITO) has several unique properties

Critical raw materials (CRM) are extensively used in tools for metal cutting, such as in cemented carbide tools (cobalt and tungsten), because they provide desired characteristics of high fracture toughness and wear resistance. Both academia and industry are examining CRM-free material alternatives, such as tools based on polycrystalline diamond (PCD) or ceramic materials. These materials are gene

Lunds universitet har uppmanats att ge synpunkter på rubricerad remiss. Universitetet lämnar här följande kommentarer vilka har utarbetats vid Ekonomihögskolan vid Lunds universitet av docent Fredrik N G Andersson och professor emeritus Lars Jonung. Inflationsmålet infördes för över 25 år sedan. Villkoren för att bedriva penningpolitik har förändrats på ett omvälvande sätt under detta kvartssekel.

A solution to the quasistatically propagating mode III crack in an elastic perfectly plastic solid is obtained as the limit solution for vanishingly small linear strain hardening. A point above or below the crack plane will experience, first, a centered fan slip line field followed at the angle ±32.8° ahead of the crack tip by elastic unloading and, finally, from the angle ±179.7° to the crack sur

For quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has causeFor quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has cause

Partially Premixed Combustion (PPC) has shown to be a promising advanced combustion mode for future engines in terms of efficiency and emission levels. The combustion timing should be suitably phased to realize high efficiency. However, a simple constant model based predictive controller is not sufficient for controlling the combustion during transient operation. This article proposed one learning

I detta kapitel i boken Geografisk information Behandling beskrivs och behandlas metoder för hur geografisk data analyseras. Kapitlet omfattar såväl geografisk teori som exempel på tillämpningar. Geografisk informationsbehandling baseras på insamling, lagring, analys och visualisering av geografiska data. Denna indelning utgör också grunden för bokens disposition. Boken är i första hand avsedd för