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Femtosecond and nanometre visualization of structural dynamics in superheated nanoparticles

The ability to observe ultrafast structural changes in nanoscopic samples is essential for understanding non-equilibrium phenomena such as chemical reactions, matter under extreme conditions, ultrafast phase transitions and intense light-matter interactions. Established imaging techniques are limited either in time or spatial resolution and typically require samples to be deposited on a substrate,

Underwater ERT surveying in water with resistivity layering with example of application to site investigation for a rock tunnel in central Stockholm

We present an approach to underwater electrical resistivity tomography surveying under conditions with several water layers with different resistivity in the water above the electrode layout. The approach is verified against a synthetic model example and tested in full scale on data from a field survey. The field survey was carried out in central Stockholm as part of pre-investigations for a new m

Molecular Movies from Molecular Frame Photoelectron Angular Distribution (MF-PAD) Measurements

We discuss recent and on-going experiments, where molecular frame photoelectron angular distributions (MFPADs) of high kinetic energy photoelectrons are measured in order to determine the time evolution of molecular structures in the course of a photochemical event. These experiments include, on the one hand, measurements where single XUV/X-ray photons, obtained from a free electron laser (FEL) or

Cracking the Sugar Code by Mass Spectrometry : An Invited Perspective in Honor of Dr. Catherine E. Costello, Recipient of the 2017 ASMS Distinguished Contribution Award

The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the s

The role of therapy in impairing quality of life in dermatological patients : A multinational study

Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Therapy issues were reported by a majority of patients with ato

Analytic representation of FK /Fπ in two loop chiral perturbation theory

We present an analytic representation of FK/Fπ as calculated in three-flavor two-loop chiral perturbation theory, which involves expressing three mass scale sunsets in terms of Kampé de Fériet series. We demonstrate how approximations may be made to obtain relatively compact analytic representations. An illustrative set of fits using lattice data is also presented, which shows good agreement with

Discordant molecular subtype classification in the basal-squamous subtype of bladder tumors and matched lymph-node metastases

Molecular subtypes of muscle-invasive bladder tumors have emerged as a promising research tool with potential to stratify patients for neoadjuvant treatment. Prior to radical cystectomy, the utility of molecular classification and biomarkers depend on concordance between tissue from transurethrally resected specimens and disseminated disease. We assess the concordance of molecular subtypes and a l

East versus West: Energy intensity in coal-rich Europe, 1800–2000

This paper presents a stylized graph of the energy intensities in two typical European sets of countries: the East and the West, in parallel to the existing research on the European North – South. The coal-rich West and East differ from the coal-poor South and North, in that their pattern is an inverted U-curve, while both North and South have consistently declining energy intensities. Energy inte

Mechanical complications of central venous catheter insertions : A retrospective multicenter study of incidence and risks

BACKGROUND: Incidence and risk factors for complications after insertion of central venous catheters have previously been reported for smaller cohorts. The aim of this observational multicenter study was to study risk factors for mechanical complications in a large, recently collected cohort of patients.METHODS: Records of central venous catheter insertions from 8 hospitals in southern Sweden from

ϕ meson production at forward rapidity in Pb–Pb collisions at √sNN=2.76 TeV

ϕ meson measurements provide insight into strangeness production, which is one of the key observables for the hot medium formed in high-energy heavy-ion collisions. ALICE measured ϕ production through its decay in muon pairs in Pb–Pb collisions at sNN=2.76 TeV in the intermediate transverse momentum range 2 < pT< 5 GeV/c and in the rapidity interval 2.5 < y< 4. The ϕ yield was measured as a functi

Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo

The polyether ionophore salinomycin has recently captured much interest due to its potent activity against multi-drug resistant cancer cells and cancer stem cells. Previous studies have shown that either acylation of the C20 position or esterification/amidation of the C1 carboxylate moiety is beneficial in terms of biological properties. In this paper, we present the first analogs combining such m

Effect of Gate Oxide Defects on Tunnel Transistor RF Performance

Tunnel field-effect transistors (TFETs) are designed for low off-state leakage and low drive voltages. To investigate how capable TFETs are of RF operation, we measured their scattering parameters and performed small-signal modeling. We find that in the low frequency ranges, gate oxide defects have a major influence on the RF performance of these devices, which can be modeled by a frequency-depend

Nocturnal nasal obstruction is frequent and reduces sleep quality in patients with obstructive sleep apnea

The prevalence and consequences of nasal obstruction in untreated obstructive sleep apnea patients are not known. The study objectives were to investigate the frequency of subjective and objective nasal obstruction in untreated sleep apnea patients and the associations with sleep and quality of life. Patients in the Icelandic Sleep Apnea Cohort were subjected to a type 3 sleep study, answered ques

Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis

Despite the essential role of thymic epithelial cells (TEC) in T cell development, the signals regulating TEC differentiation and homeostasis remain incompletely understood. In this study, we show a key in vivo role for the vitamin A metabolite, retinoic acid (RA), in TEC homeostasis. In the absence of RA signaling in TEC, cortical TEC (cTEC) and CD80loMHC class IIlo medullary TEC displayed subset