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Fragmented reindeer of Stállo foundations : A multi-isotopic approach to fragmented reindeer skeletal remains from Adámvallda in Swedish Sápmi

This study focusses on the fragmented remains of unburnt reindeer skeletal elements found at three Stállo foundations and a hearth at Adámvallda in inland northern Sweden and Sápmi. Stállo foundations are usually identified as Sámi settlement sites for reindeer hunters or as the remains of an early Sámi pastoral society; however, the finds are scarce and often fragmented. In this study, I aim to s

Effect of controlled hypotensive hemorrhage on plasma sodium levels in anesthetized pigs : An exploratory study

Perioperative hyponatremia, due to non-osmotic release of the antidiuretic hormone arginine vasopressin, is a serious electrolyte disorder observed in connection with many types of surgery. Since blood loss during surgery contributes to the pathogenesis of hyponatremia, we explored the effect of bleeding on plasma sodium using a controlled hypotensive hemorrhage pig model. After 30-min baseline pe

Challenges and opportunities for early career medical professionals in cardiovascular magnetic resonance (CMR) imaging : a white paper from the Society for Cardiovascular Magnetic Resonance

The early career professionals in the field of Cardiovascular Magnetic Resonance (CMR) face unique challenges and hurdles while establishing their careers in the field. The Society for Cardiovascular Magnetic Resonance (SCMR) has expanded the role of the early career section within the society to foster the careers of future CMR leaders. This paper aims to describe the obstacles and available oppo

Age logics in social work: The case of harm reduction for people over the age of 50 with long-term substance use problems residing in wet eldercare facilities in Sweden

Age is a commonly used criterion in social work, whether for entry and exit or for decisions about the appropriate measures for clients. This study introduces the concept of age logics in social work and investigates the use of age in ‘wet’ eldercare facilities. Wet eldercare facilities are harm reduction arrangements open to people over the age of 50 with long-term substance misuse. No treatment Age is a commonly used criterion in social work, whether for entry and exit or for decisions about the appropriate measures for clients. This study introduces the concept of age logics in social work and investigates the use of age in ‘wet’ eldercare facilities. Wet eldercare facilities are harm reduction arrangements open to people over the age of 50 with long-term substance misuse. No treatment

Rural mobility in later life; counteracting accessibility poverty with digital service solutions

Norrbotten region is one of the most sparsely populated areas in Europe, with often long distances to services. This paper aims to gain a deeper understanding of the everyday mobilities in later life in rural areas, and to assess to what extent digital service solutions (DiSS) can contribute to reduced accessibility poverty. The study focuses on how DiSS contribute to more equitable accessibility

The association between BCG treatment in patients with bladder cancer and subsequent risk of developing Alzheimer and other dementia.-A Swedish nationwide cohort study from 1997 to 2019

Background Alzheimer's disease (AD) affects 50 million people worldwide. The immune system plays a major role in the pathogenesis of AD. Several retrospective analyses have reported a decreased risk of AD and other dementias in bladder cancer patients treated with immunotherapy in the form of Bacillus Calmette-Guerin (BCG) bladder instillations. We tested this hypothesis in a Swedish population-ba

Role of hospital and patient factors in the outcome of reoperations for primary hyperparathyroidism : a retrospective multicenter cohort study

BACKGROUND: There are few data on outcomes after reintervention for persistent or recurrent primary hyperparathyroidism (PHPT). The authors hypothesized that the variation in outcomes at the hospital level after reoperation would be significant. After accounting for this variability, some patient-level clinical criteria could be identified to help inform treatment decisions in this patient populat

Uncovering the Electronic State Interplay at Metal Oxide Electron Transport Layer/Nonfullerene Acceptor Interfaces in Stable Organic Photovoltaic Devices

The implementation of sputter-deposited TiOx as an electron transport layer in nonfullerene acceptor-based organic photovoltaics has been shown to significantly increase the long-term stability of devices compared to conventional solution-processed ZnO due to a decreased photocatalytic activity of the sputtered TiOx. In this work, we utilize synchrotron-based photoemission and absorption spectrosc

Long-Term Outcome of Graves’ Disease : A Gender Perspective

Introduction: In gender-skewed conditions such as Graves’ disease (GD), the outcome naturally becomes dominated by the majority. This may lead to gender-biased misunderstandings regarding treatment outcomes. This especially holds true when complications, such as depression, are unevenly distributed. We have, therefore, studied the long-term outcome of GD from a gender perspective. Materials and Me

Long travel times from health center to hospital reduce caesarean section access : a study from Kirehe District, Rwanda

Introduction: timely access to safe cesarean section (c-section) delivery can save the lives of mothers and neonates. This paper explores how distance affects c-section access in rural sub-Saharan Africa, where women in labor present to health centers before being referred to district hospitals for surgical care. Methods: this study included all adult women delivering via c-section between April 2

Meaning in Life in Late-Stage Parkinson’s Disease : Results from the Care of Late-Stage Parkinsonism Study (CLaSP) in Six European Countries

The Care of Late-Stage Parkinsonism (CLaSP) study is a longitudinal, multicentre, prospective cohort study to assess the needs and provision of care for people with late-stage Parkinson’s disease and their caregivers in six European countries. As a cross-sectional study within the CLaSP study, 509 people with Parkinson’s disease completed the “Schedule-for-Meaning-in-Life-Evaluation” (SMiLE) quest

A network architecture for scalable end-to-end management of reusable AI-based applications

Artificial intelligence (AI) is a key enabler for future 6G networks. Currently, related architecture works propose AI-based applications and network services that are dedicated to specific tasks (e.g., improving the performance of RAN with AI). These proposed architectures offer a unique way to collect data, process it, and extract features from data for each AI-based application. However, this d

Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source

Serial and time-resolved macromolecular crystallography are on the rise. However, beam time at X-ray free-electron lasers is limited and most thirdgeneration synchrotron-based macromolecular crystallography beamlines do not offer the necessary infrastructure yet. Here, a new setup is demonstrated, based on the JUNGFRAU detector and Jungfraujoch data-acquisition system, that enables collection of k

Basal activity of PINK1 and PRKN in cell models and rodent brain

The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective degradation (mitophagy). Complete loss of PINK1 or PRKN function unequivocally leads to early-onset Parkinson disease, but it is debated whether impairments in mitophagy contribute to disease later in life. While the pathway

Exponential moments for disk counting statistics at the hard edge of random normal matrices

We consider the multivariate moment generating function of the disk counting statistics of a model Mittag-Leffler ensemble in the presence of a hard wall. Let n be the number of points. We focus on two regimes: (a) the “hard edge regime” where all disk boundaries are at a distance of order n1 from the hard wall, and (b) the “semi-hard edge regime” where all disk boundaries are at a distance of ord

Pollination supply models from a local to global scale

Ecological intensification has been embraced with great interest by the academic sector but is still rarely taken up by farmers because monitoring the state of different ecological functions is not straightforward. Modelling tools can represent a more accessible alternative of measuring ecological functions, which could help promote their use amongst farmers and other decision-makers. In the case

Quantum information perspective on meson melting

We propose to use quantum information notions to characterize thermally induced melting of nonperturbative bound states at high temperatures. We apply tensor networks to investigate this idea in static and dynamical settings within the Ising quantum field theory, where bound states are confined fermion pairs - mesons. An equilibrium signature of meson melting is identified in the temperature depen

DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis

Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora o

Eigenvalues of truncated unitary matrices : disk counting statistics

Let T be an n× n truncation of an (n+ α) × (n+ α) Haar distributed unitary matrix. We consider the disk counting statistics of the eigenvalues of T. We prove that as n→ + ∞ with α fixed, the associated moment generating function enjoys asymptotics of the form exp(C1n+C2+o(1)), where the constants C1 and C2 are given in terms of the incomplete Gamma function. Our proof uses the uniform asymptotics