Search results

Abstract Thiosilvatins are a family of biologically active sulfenylated diketopiperazine natural products. The first members were reported over 40?years ago, but total synthesis of a thiosilvatin has remained elusive. Here, we describe the first, collective, synthesis of the parent epidithiodiketopiperazine (?)-dithiosilvatin and ten related thiosilvatins. Several of the targets are structurally rThiosilvatins are a family of biologically active sulfenylated diketopiperazine natural products. The first members were reported over 40 years ago, but total synthesis of a thiosilvatin has remained elusive. Here, we describe the first, collective, synthesis of the parent epidithiodiketopiperazine (−)-dithiosilvatin and ten related thiosilvatins. Several of the targets are structurally revis

Två böcker som analyserar västvärldens predikament efter Trump I är väl värda att begrunda även om de farhågor författarna ventilerar har antagit oanade proportioner efter Trump II: Peter Heathers och John Rapleys Why Empires Fall (Allen Lane 2023) och Martin Wolfs The Crisis of Democratic Capitalism (Penguin Books 2024).

The ethics of blame includes conditions determining whether an instance of blame is permissible. One generally recognised condition is that blame should be proportionate. If it is not proportionate, that speaks against its permissibility. All the same, what exactly amounts to proportionate blame is currently under-theorised. In this paper, we aim to amend this. More precisely, we distinguish betwe

Collecting detailed hydrogeological data before, during, and after remediation campaigns is essential for effective management and monitoring of contaminated sites. As in-situ remediation injection treatment becomes more popular, recording the hydraulic response during these events offers an opportunity to collect detailed data on hydrogeological parameters. Often, multiple injections are performe

Widespread autumn cooling occurred in the northern hemisphere (NH) during the period 2004-2018, primarily due to the strengthening of the Pacific Decadal Oscillation and Siberian High. Yet, while there has been considerable focus on the warming impacts, the effects of natural cooling on autumn leaf senescence and plant productivity have been largely overlooked. This gap in knowledge hinders our un

Market failure is a concept invoked in both economics and public policy to justify governmental interventions in the marketplace. Drawing on more than five years of qualitative research on public transport in Stockholm, this paper explores how market failure, operating as a form of folk theory within public policy, informed a legal reform. This reform aimed to reconfigure an established contractua

The first part of the first volume of the Swedish Academy Dictionary (SAOB) was published in 1893 and the last volume was finished in 2023. Thus Sweden’s most extensive lexicographical project was completed after more than 130 years of work. But the completion is not the end of the dictionary project. Since 2024 a revision project is launched. In this paper the history of the dictionary project isThe first part of the first volume of the Swedish Academy Dictionary (SAOB) was published in 1893 and the last volume was finished in 2023. Thus Sweden’s most extensive lexicographical project was completed after more than 130 years of work. But the completion is not the end of the dictionary project. Since 2024 a revision project is launched. In this paper the history of the dictionary project is

In this paper, a doctoral study on the description of semantic change in the Swedish Academy Dictionary (SAOB) is presented. The starting point for the study is semantic labels like figurative and in extended use. Five such labels in SAOB are examined, mainly with methods from the cognitive linguistic framework. The results show, among other things, that the most labelled mechanism is metaphor, th

In 2023, the first edition of the diachronic-contemporary Swedish AcademyDictionary (SAOB) was finished after more than 130 years of work. The dictionary contains over 500,000 entries and describes the Swedish language from the 1520s to the present day. However, a consequence of the extended time of publication is that a significant part of the content, in particular in the first volumes, was out In 2023, the first edition of the diachronic-contemporary Swedish Academy Dictionary (SAOB) was finished after more than 130 years of work. The dictionary contains over 500,000 entries and describes the Swedish language from the 1520s to the present day. However, a consequence of the extended time of publication is that a significant part of the content, in particular in the first volumes, was out

Berättelsen om Katalonien har under senare år handlat om försöken att bryta sig loss från Spanien. Men vid sidan om de politiska slitningarna har regionens litteratur fått stort genomslag, inte minst genom den katalanskspråkiga författaren Irene Solà. Kanske närmar vi oss en ny renaixença?

Henrik Brandão Jönsson blandar kulturhistoria, reseskildring, migrationsberättelse och självreflektion. Hans nya bok kretsar kring det djupt emotionella begreppet saudade. Christian Claesson läser en bok om att längta bort och hem samtidigt.

A summary is presented of the Late Weichselian and early Holocene changes of vegetation, climate and sea level on the Skagi peninsula, northern Iceland, as reflected in bio- and lithostratigraphic data from five sediment sequences. The period 11,300-10,900 BP was characterized by grass-tundra vegetation and low lake productivity, indicating cold climatic conditions. Milder conditions after 10,900

Understanding stellar evolution and its effect on planetary systems is crucial for correctly interpreting the chemical constraints of exo-planetary material that can be given to us by white dwarfs. This article will describe how asteroids, moons, and comets, as well as boulders, pebbles and dust, evolve into eventual targets for chemical spectroscopy, and how planets and companion stars play a vit