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The Danish royal flagship gribshunden : Dendrochronology on a late medieval carvel sunk in the Baltic Sea

The Royal flagship Gribshunden carried the Danish King Hans on its way to the city of Kalmar in Sweden when the ship sank in the summer of 1495. The ship caught fire while anchored north of the Stora Ek o Island and sank to the seafloor, where it lies to this day. The wreck was rediscovered in the 1970s and is remarkably well preserved.Since 2001, scientific investigations have been performed on t

Income Taxes and Redistribution in the Early Twentieth Century

This paper studies the developments in the income taxes of Sweden, the United Kingdom, and the United States during the first half of the twentieth century. We present the evolution of marginal and average effective tax rates, number of taxpayers, and income tax due over the whole income distribution, and calculate the corresponding indices of progressivity and redistribution.Our results show that

Progger: Programming by Errors (Work In Progress)

This paper describes a work in progress implementation of a programming tool that puts errors and their provenance at the forefront of the interaction between a developer and a compiler. We discuss the motivation for such a tool, it’s design and implementation, and reflect upon avenues for further research which it can facilitate.

The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy : A Population-Based Cohort Study

The aryl hydrocarbon receptor (AhR) is a master regulator of multiple pathways involved in breast cancer, and influences the estrogen receptor alpha (ER) and aromatase/CYP19A1. The purpose of this study was to elucidate the interplay between intratumoral levels of AhR and aromatase, patient characteristics (including AhR and CYP19A1 genotypes), clinicopathological features, and prognosis in breast

Impact of Holocene climate change on silicon cycling in Lake 850, Northern Sweden

Diatom-rich sediment in a small subarctic lake (Lake 850) was investigated in a 9400 cal. yr BP sediment record in order to explore the impact of Holocene climate evolution on silicon cycling. Diatom stable silicon isotopes (δ30SiBSi ) and biogenic silica (BSi) indicate that high BSi concentrations in sediment throughout the Holocene are associated with a lighter Si isotope source of dissolved sil

Steerable sheath for exclusively femoral bilateral extension of previous fenestrated endovascular aneurysm repair with iliac branch devices

We report the treatment of type Ib endoleak after fenestrated endovascular aneurysm repair (FEVAR) with iliac branch device (IBD) to allow exclusive transfemoral access without a femoral-to-femoral through-and-through wire. The patient was treated with fenestrated endovascular aneurysm repair and showed expansion of the aneurysm owing to a type Ib endoleak. An IBD was implanted by the use of a con

Projected losses of ecosystem services in the US disproportionately affect non-white and lower-income populations

Addressing how ecosystem services (ES) are distributed among groups of people is critical for making conservation and environmental policy-making more equitable. Here, we evaluate the distribution and equity of changes in ES benefits across demographic and socioeconomic groups in the United States (US) between 2020 and 2100. Specifically, we use land cover and population projections to model poten

Large eddy simulation of n-heptane/syngas pilot ignition spray combustion : Ignition process, liftoff evolution and pollutant emissions

The utilization of syngas in the internal combustion engine is one way to reach low carbon emission engine. The n-heptane/syngas pilot ignition spray combustion is simulated here by high fidelity model with different syngas compositions. It is found that the ambient syngas suppresses the ignition by diluting the ambient oxidizer (non-chemical effect) and by affecting the chemical reactions (chemic

Population-based mammography screening attendance in Sweden 2017–2018 : A cross-sectional register study to assess the impact of sociodemographic factors

Sweden has a population-based mammography screening programme for women aged 40–74. The objective of this study was to examine the association between mammography screening attendance and sociodemographic factors in 15 of Sweden's 21 health care regions. Register-based information was collected on all mammography screening invitations and attendance during 2017 and 2018, and linked to individual-l

Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity

Heparan sulfate mediates numerous complex biological processes. Its action critically depends on the amount and the positions of O-sulfate groups (iduronyl 2-O-sulfates, glucosaminyl 6-O- and 3-O-sulfates) that form binding sites for proteins. The structures and distribution of these protein-binding domains are influenced by the expression and substrate specificity of heparan sulfate biosynthetic

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases

Glycosaminoglycan heparan sulphate interacts with a variety of proteins, such as growth factors, cytokines, enzymes and inhibitors and, thus, influences cellular functions, including adhesion, motility, differentiation and morphogenesis. The interactions generally involve saccharide domains in heparan sulphate chains, with precisely located O-sulphate groups. The 6-O-sulphate groups on glucosamine

Going to extremes - a metagenomic journey into the dark matter of life

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation val

Deconstructing North Sámi sensive verbs

North Sámi has a class of derived verbs called sensive verbs. Descriptively, these verbs are formed by adding the suffix /ʃ/ to an adjectival or nominal base, and the resulting verb means ‘find [object] (too) ADJECTIVE/NOUN’. In this paper it is argued that the sensive verbs do not involve any psychological verb, and the suffix is not specified as “sensive” in the lexicon. Rather, the suffix is spNorth Sámi has a class of derived verbs called sensive verbs. Descriptively, these verbs are formed by adding the suffix /ʃ/ to an adjectival or nominal base, and the resulting verb means ‘find [object] (too) ADJECTIVE/NOUN’. In this paper it is argued that the sensive verbs do not involve any psychological verb, and the suffix is not specified as “sensive” in the lexicon. Rather, the suffix is sp

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Få, om noen, kan gjøre Jomfru Maria rangen stridig som mest betydningsfull kvinneskikkelse i den kristne verden – iallfall slik religionen ser ut i dag. Blant katolikker og ortodokse er hun gjenstand for en nesten bunnløs folkelig hengivenhet, og mange protestanter nærer dyp kjærlighet til og respekt for henne. Også muslimer verden over oppfatter Jesu mor som et forbilde og søker blant annet henne

Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients

Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessi