The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease developmen

The main aim of this bachelor thesis is to push the limits of 3D X-ray imaging by studying the minimum number of projections required to retrieve high-quality reconstructions for additive manufacturing processes. This project first focuses on understanding how X-ray tomography works, by reconstructing additive manufacturing data already obtained (from PSI, TOMCAT beamline) using two standard recon

Purpose: Hodgkin lymphoma (HL) survivors are known to have increased cardiac mortality and morbidity. The risk of developing cardiovascular disease after involved node radiotherapy (INRT) is currently unresolved, inasmuch as present clinical data are derived from patients treated with the outdated mantle field (MF) technique. Methods and Materials: We included all adolescents and young adults with

Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highl

Durability and service life assessment is a major challenge for the design and use of timber in outdoor weather exposed environments. Rate of deterioration by fungal decay is closely linked to variations in wood moisture content. The objective of the present paper is to test and evaluate different data-driven models based on the multilinear regression (MLR) and artificial neural network (ANN) appr

In this paper, a comparative study of core losses in laminated steel samples by means of inferential statistics is presented. In particular, core loss measurements taken upon Epstein Frame, Single-Strip tester, and Ring Core specimens at several frequencies and induction levels are compared via Analysis of Variance and two-sample t-tests. The hypothesis of a statistically significant difference am

The machining of Fiber Reinforced Polymers (FRP) is accompanied by specific defects such as delamination, uncut fibers, and others. Such defects are unique in their shape and size for different FRP types, used tools, and applied cutting conditions. Therefore, defect recognition and quantification remain a central challenge in the quality control of FRP components from an accuracy and time balance

Examensarbetets titel: Motstånd utan avstånd - En kvalitativ studie om medarbetares upplevelser av stark företagskultur. Seminariedatum: 2023-06-02 Kurs: FEKH49- Examensarbete i organisation på kandidatnivå, 15 högskolepoäng. Författare: Lisa Mattiasson, Ida Pålsson, Emma Schyldt Handledare: Nadja Sörgärde Fem nyckelord: Företagskultur, organisationskultur, osynligt motstånd, omedvetet mots

This study investigated the dosimetric impact of uncompensated motion and motion compensation with dynamic multileaf collimator (DMLC) tracking for prostate intensity modulated arc therapy. Two treatment approaches were investigated; a conventional approach with a uniform radiation dose to the target volume and an intraprostatic lesion (IPL) boosted approach with an increased dose to a subvolume o

Samtida forskning om psykisk hälsa och välbefinnande har tagit upp behovet av att fördjupa vår förståelse om ungdomslivets beskaffenhet och sammanhang. Vårt forskningssyfte är att undersöka positiva och negativa erfarenheter gällande skola, familj, vänner och fritid hos ett urval av svenska 13–19-åringar. Vi använder ramverksanalys för att organisera data och närmar oss analysen genom att använda Contemporary research on mental health and well-being has addressed the need to deepen our understanding about the nature of adolescent life and contexts. Our research aim is to examine positive and negative experiences concerning school, family, friends, and leisure time in a sample of Swedish 13–19-year- olds. We use the framework method to organize data and approach the analysis by following An

Protein aggregates are a hallmark of Alzheimer's disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What happens to Bax if it fails to target mitochondria? We previously showed that a mitochondrial target-d

BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of

ObjectiveTo determine the feasibility of a digitally automated population-based programme for organised prostate cancer testing (OPT) in Southern Sweden.Patients and MethodsA pilot project for a regional OPT was conducted between September 2020 and February 2021, inviting 999 randomly selected men aged 50, 56, or 62 years (y). Risk stratification was based on PSA, PSA density (PSAD), and biparamet

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors. Despite occurring decades before the typical age of an AD diagnosis, early-life stress (ELS) has been suggested to have long-lasting effects that may contribute to AD risk and pathogenesis. S

Detta examensarbete handlar om de problem relaterade till kabelskador som uppstår idag i samband med kabelutsättning vid grävarbeten inom järnväg. Kabelutsättning utförs vanligtvis av en underhållsentreprenör, som utförs genom att markera markytan där kabel under marken kan tänkas finnas. Instrument som används för att lokalisera kabel fungerar relativt bra men kan störas av spänningsförande anlägThis thesis addresses the problem related to cable damages that arise today during cable exposure in railway excavation works. Cable exposure is typically carried out by a maintenance contractor, marking the ground surface where underground cables are located. The instruments used for cable localization functions relatively well but can be disrupted by nearby electrical infrastructure. Consequen

Monte Carlo N-Particle (MCNP) is a Monte Carlo code package allowing coupled neutron, photon, and electron transport calculations. Also, the possibility of performing heavy charged particle transport calculations was recently introduced with the twin MCNPX code package. An arbitrary three-dimensional problem can be formulated through the use of surfaces defining building blocks (“cells” that are a

BackgroundEnsuring equivalent and reproducible breast compression between mammographic screening rounds is important for the diagnostic performance of mammography, yet the extent to which screening mammography positioning and compression is reproducible for the individual woman is unknown.PurposeTo investigate the intra- and inter-rater reliability of breast compression in screening mammography.Ma