Search results

Filter

Filetype

Your search for "*" yielded 533230 hits

Increased concentrations of bone sialoprotein in joint fluid after knee injury

Objective - To detect evidence for localised changes in bone matrix metabolism after joint trauma and in post-traumatic osteoarthritis by quantification of bone sialoprotein in joint fluid and serum after knee injury in a cross sectional study. Methods - Samples of knee joint fluid and serum were obtained from volunteers with normal knees (n = 19), patients with rupture of the anterior cruciate li

What Became of the New Public Diplomacy? : Recent Developments in British, U.S. & Swedish Public Diplomacy Policy and Evaluation Methods

This article examines the relationship between theories of the ‘new’ public diplomacy and recent attemptsby foreign ministries in the United Kingdom, United States and Sweden to develop public diplomacystrategies for the early twenty-first century. It provides a summary of policy debates in each nation alongsideanalysis of the evaluation methods that have been designed to support them. The article

Innovations in public diplomacy and nation brands : Inside the house of Sweden

This article investigates innovations in public diplomacy and nation brands through the example of Sweden's Embassy in Washington, DC, the House of Sweden (HoS). The analysis explores the styles of communication and public outreach made possible by the interaction between its architectural design, brand values and public diplomacy applications. Aimed at practitioners and scholars with an interest

The Limits of the New Public Diplomacy : Strategic Communication and Evaluation at the Foreign & Commonwealth Office, British Council, U.S. State Department, Swedish Foreign Ministry & Swedish Institute

The new public diplomacy is a major paradigm shift in international political communication. Globalisation and a new media landscape challenge traditional foreign ministry ‘gatekeeper’ structures, and foreign ministries can no longer lay claim to being sole or dominant actors in communicating foreign policy. This demands new ways of communicating foreign policy to a range of nongovernmental intern

Photoemission study of the Bi2CaSr2Cu2O8 superconductor with Cu, Ag and Au overlayers

In this paper, we present a photoemission study of the interaction of Cu, Ag and Au with clean single-crystal Bi2CaSr2Cu2O8 superconductor surfaces. Both the valence-band and the Bi 5d, O 1s and Sr 3d core levels were monitored for all overlayers. Cu, Ag and Au were deposited as consecutively thicker layers starting with a third of a monolayer and progressing in steps up to a deposition in the ran

Candida albicans arthritis in a nonimmuno-compromised patient : Complication of placebo intraarticular injections

A nonimmunocompromised 32-year-old man with arthrosis of the knee participated as a placebo control in a clinical trial of intraarticular injections of hya-luronan. After the fourth weekly injection of saline, he developed a warm and swollen knee, and synovia! fluid cultures revealed growth of Candida albicans. Oral fluconazole treatment was instituted 2 weeks after onset of symptoms, but failed t

A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture-synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1

This is the first study which quantifies aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinases-1 (TIMP-1) in SF samples prospectively obtained from the same patient at different time intervals after a cruciate ligament injury of the knee. Aggrecan fragment concentrations were determined by dye precipitation with Alcian Blue. Stromelysin-1 and TIMP-1 were analysed by immunoas

The prevalence of gonarthrosis and its relation to meniscectomy in former soccer players

The prevalence of radiographic signs of gonarthrosis and its relation to knee injuries were studied in 286 former soccer players-215 nonelite and 71 elite players-and were compared with 572 age-matched controls with a mean age of 55 years. The prevalence of gonarthrosis among the nonelite players was 4.2%, among the elite players 15.5%, and among the controls 1.6%. Seven of the soccer players had

Aggrecan degradation in human cartilage : Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in VDIPEN341 were compared with the distribution of aggrecanase-generated G1 fragments terminating in NI

Defining the role of molecular markers to monitor disease, intervention, and cartilage breakdown in osteoarthritis

Osteoarthritis (OA) is associated with a loss of the normal balance between synthesis and degradation of the macromolecules that provide articular cartilage with its biomechanical and functional properties. The destruction of joint cartilage involves the degradation of matrix molecules which are released as fragments to joint fluid, blood, and urine, where they may be detected, for example, by imm

The limits of supply chain responsibility – A critical analysis of CSR instruments

One challenge in the area of supply chain management has been achieving sustainable compliance with labour rights throughout the entire production chain, including lower tiers of production. This article inquires specifically around sub-contracting, especially what is a brand’s or a buyer’s responsibility regarding workers’ rights beyond its first tier of suppliers. In-depth literature on this iss

Markers of cartilage metabolism in arthrosis

The mechanisms involved in the disease process in arthrosis are largely unknown, with genetics, joint malalignment, overload or trauma, obesity, and aging as some of the known or suspected contributing factors. Even less well known is how these general factors are translated into disease mechanisms at the cell and tissue levels. However, it may be argued that degradation of cartilage matrix is a k

Cartilage metabolism in the injured and uninjured knee of the same patient

Objective-To examine if unilateral knee injury affects the synovial fluid concentrations of aggrecan fragments, cartilage oligomeric matrix protein (COMP) fragments, stromelysin-l, and tissue inhibitor of metalloproteinases-l (TIMP-1) in the contralateral uninjured knee. Methods-Synovial fluids from the injured and uninjured knees were obtained at different times in a group of patients after unila

What is the current status of biochemical markers in the diagnosis, prognosis and monitoring of osteoarthritis?

Biochemical markers for osteoarthritis (OA) may serve different purposes. Since markers reflect ongoing dynamic metabolic processes in the joint tissues (cartilage, synovium, bone, etc.), they are most likely to be useful to predict prognosis and response to treatment, to monitor response to treatment, and for disease staging. Markers are currently being used at the research level for these purpos