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Transcriptome profiles associated with neurodegeneration in the Engrailed-1 mouse model for Parkinson’s disease

Parkinson’s disease (PD) is a highly heterogenous disorder characterized by bradykinesia, rigidity, rest tremor and non-motor symptoms like cognitive impairment, anosmia, and sleep disturbance. The underlying pathological hallmarks of PD are the degeneration of dopaminergic pigmented neurons in the substantia nigra pars compacta, neuroinflammation and, alpha synuclein inclusions accumulating into

Activating Brand Nostalgia: A case study of Cuba Cola and Igloo

Abstract Purpose: The purpose of this study is to understand the strategic choices made to activate nostalgia in the relaunches of Igloo and Cuba Cola. Methodology: Qualitative research based on primary and secondary data. Primary data was created by three interviews. Two case studies were conducted and analyzed over two time periods by applying the ‘Corporate Brand Identity Matrix’ and ‘4A:s of r

Restaurant industry's response to Covid-19

Purpose – The key objective of this research is to discuss different restaurant strategies that emerged in Belgium, Bulgaria, Denmark and Sweden in response to the Covid-19 pandemic and relate the respective restaurant activities to brand trust and reputation. Therefore, the restaurant industry is analyzed with respect to the pandemic and findings are put into context by explaining the countries’

Feasibility study of the polymerization and use of allylamine as a component in anion-exchange membranes

Utvecklingen av anjonbytarmembran som kombinerar långvarig termokemisk stabilitet, hög hydroxidjonledningsförmåga med adekvata mekaniska egenskaper för alkaliskt elektrokemiskt system, är för närvarande ett brett forskningsområde. I det aktuella arbetet undersöker vi radikalpolymerisationen av allylamin, särskilt i organiska lösningsmedel, som uppnåddes genom direkt polymerisering av den protoneraThe development of anion-exchange membranes that combine long-term thermochemical stability, high hydroxide ion conductivity with adequate mechanical properties for alkaline electrochemical system, is currently a wide research area. In the present work, we investigate the radical polymerization of allylamine, especially in organic solvents, which was achieved by directly polymerizing the protonate

The Digital Friend

This thesis examines the relationship between the architect and its digital tools, from the perspective that technology constantly is evolving. We believe that the architect’s relationship with its tools changes with the advancement of technology. That being said, we developed an investigative methodology based on generative design that we later applied to a more conventional architectural project

"Tack och lov att Google finns" - mödrars upplevelser av och tankar om stöd och information kring amning

Amning under barnets första månader minskar i Sverige. Nittiofem procent av nyblivna mödrar i Sverige ammar, helt eller delvis, under barnets första vecka, vilket tyder på att de flesta har intentionen och viljan att amma. En stor andel kvinnor upplever dock problem vid amning, vilket kan förklara varför många slutar amma tidigare än amningsrekommendationen anger. Syftet med studien är att beskriv

The Art of Scarcity

The purpose of this paper is to explore the phenomenon of scarcity in branding within the fashion industry. Secondly, the aim is to show how fashion brands can utilize scarcity as a branding tool to transform products into luxury collector’s fashion items. The research shows that there are several connections between the presented cases.By combining the time and quantity scarcity appeal as well as

Frankful, the game changer in the taco shelf

Purpose: The importance of satisfying each target groups’ needs and wants is increasingly becoming harder though the consumers are more aware and knowledgeable concerning the environment and healthier food choices. This paper examines how the newly launched Swedish tex-mex brand, Frankful, is satisfying the needs and wants of their target group, millennials, through their unique positioning and br

Antagonistic Nation Branding Strategies: The Case of North Korea

Purpose: This paper aims to uncover the complexity of nation branding strategies, specifically in relation to antagonistic nations using a case study of North Korea. Design/methodology/approach: To provide background context and discuss all relevant theories to this analysis, an extensive literature review has been conducted. As such, different conceptions of corporate branding, nation branding a

Ekonomiska indikatorer samt systemfaktorer och hur de förutsäger och påverkar dödligheten i prostatacancer

Hur olika ekonomiska indikatorer och faktorer förutsäger och påverkar dödligheten i prostatacancer har i detta arbete undersökts. Tidigare forskning tyder på att där är fler faktorer som påverkar dödligheten i prostatacancer utöver sjukvårdsfinansiering och produktionsfaktorer inom sjukvården. En linjär regressionsmodellen har satts upp för sambandet mellan dödligheten i prostatacancer och total s

Once upon a time there was a signature story

Purpose – The term signature story was explored by David Aaker in his book published in 2018. The purpose of this paper is to further investigate, examine and build upon his concept. This will be done by examining and defining Aaker’s four criteria of signature stories for non-American brands to improve the criteria’s definition, explanation and usage. Design/methodology/approach – The research is

Kompetensutveckling hos distriktssköterskor inom primärvården - en intervjustudie ur ett patientsäkerhetsperspektiv

Bakgrund: Forskningen inom omvårdnad ökar och det är av största vikt att distriktssköterskor håller sig uppdaterade om den senaste kunskapen för att öka patientsäkerheten och för att upprätthålla god kvalitét på omvårdnaden. För distriktssköterskan åligger det att ta reda på nya metoder och kunna ta del av ny forskning. Möjligheten till kompetensutveckling påverkas av tidsbrist och att arbetsmiljö

The Impact of IoT on Supply Chain Management and Digital Marketing in the Fast Fashion Industry With a Focus on Zara

This study examines the impact of IoT on the supply chain management and digital marketing in the fast fashion industry with a focus on Zara. The theoretical framework is based on Porter’s Five Forces Framework and dynamic capabilities. The theory assists in understanding the competitive forces in the fast fashion industry and the capabilities necessary for firms to utilize IoT to develop new comp

Monovalent selective electrodialysis in greenhouses - An analysis of brackish groundwater and greenhouse wastewater treatment

Water use in greenhouse can be optimized by switching to alternative sources of irrigation water and building zero-liquid discharge systems that recirculate greenhouse effluent. The use of brackish groundwater (BGW) has become a popular option for greenhouses that have adopted reverse osmosis (RO) to reduce the salinity of their source water. Similarly, RO has emerged as the most commonly used des

En tematisk undersökning av främlingskapets narrativ artikulerat av författaren Theodor Kallifatides i självbiografin Ett nytt land utanför mitt fönster

This thesis examines the narrative of estrangement in Theodor Kallifatides autobiography Ett nytt land utanför mitt fönster. He presents his thoughts on an estrangement that comes with having to move to a new country and learn a new language. The autobiographical text, which constitutes the primary research material, is analytically scrutinized via a thematic narrative analysis. In other words, th

Investigation and Development of the Design Process for a Pile Group with and without Lateral Resistance from the Soil

Pålning är en typ av grundläggning lämplig för att grundlägga broar vid svaga markförhållanden. Att manuellt utforma en pålgrupp är en iterativ, tidskrävande process där snittkrafterna i pålarna måste verifieras för ett stort antal lastfall. Efter installationen kan pålarna dessutom ha nya positioner och kapaciteten måste verifieras igen. I detta projekt utvecklades en mjukvara för att automatiserFor bridges in weak ground conditions, piling is an appropriate type of foundation. To manually arrange the piles in a pile group is an iterative, time consuming process where the section forces in the piles must be verified for a large number of load cases. In addition, after installation, piles may have new positions and the capacity must be re-verified. In this thesis, a software was developed

Orientation dependant grain boundary diffusion in polycrystals

Grain boundary diffusion in polycrystals is of importance in industrial applications as it often, to a large degree, dictates the effective rate of diffusion in polycrystals. For impurity diffusion the enrichment of impurities within the material will in turn change the material properties, such as ductility and fatigue rates. It is therefor beneficial to be able to quantify the effect of the grai

Royal Beach Camp

This thesis project is a design proposal for the Royal Beach Camp (RBC) education centre, located along the Trishuli River of the Dhading region in Central Nepal. The Royal Beach Camp has been undergoing a process of shifting its focus from tourism towards education over the past two years. The site continues to offer educational programs specialising in guide accreditation for rafting, canyoneer

Activist resistance against mega-projects in Yucatan : a Buen Vivir and Degrowth approach

This thesis looks at the activist resistance in Yucatán from the perspective of theories of Buen Vivir and Degrowth. Based on a critique of mega-projects, economic growth and development, as well as a theoretical explanation of resistance in the Global South and its links to Buen Vivir and Degrowth, this research explores how mega-projects in Yucatán have existed since the age of henequen, during