Transcriptome profiles associated with neurodegeneration in the Engrailed-1 mouse model for Parkinson’s disease
Parkinson’s disease (PD) is a highly heterogenous disorder characterized by bradykinesia, rigidity, rest tremor and non-motor symptoms like cognitive impairment, anosmia, and sleep disturbance. The underlying pathological hallmarks of PD are the degeneration of dopaminergic pigmented neurons in the substantia nigra pars compacta, neuroinflammation and, alpha synuclein inclusions accumulating into
