Decompaction of DNA-CTA self-assembled complexes by 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) was studied and the results were compared with beta-CD. Different degrees of 2-HP substitution (0.6, 0.8 and 1.0, respectively) were used and the decompaction was successful with all degrees of substitution. Fluorescence microscopy, steady state fluorescence spectroscopy, density and sound velocity

The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute my

Reduced forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) have been associated with increased incidence of cardiovascular diseases. However, whether reduced lung function is also a risk factor for incidence of atrial fibrillation (AF) is still unclear. We aimed to determine whether lung function predicted AF in the Malmö Preventive Project, a large population-based coho

The potential of Saccharomyces cerevisiae for biocatalytic whole-cell transamination was investigated using the kinetic resolution of racemic 1-phenylethylamine (1-PEA) to (R)-1-PEA as a model reaction. As native yeast do not possess any ω-transaminase activity for the reaction, a recombinant yeast biocatalyst was constructed by overexpressing the gene coding for vanillin aminotransferase from Cap

Improved outcome after rectal cancer surgery requires identification of novel risk factors of tumour recurrence in order to personalise therapy, that is, enhanced selection of high-risk patients to additional radiochemotherapy or intensified follow-up. In several tumour types, including colorectal cancer, high expression of the membrane-cytoskeleton linker ezrin has been suggested to impair progno

Time-reversal (TR) signal processing has the potential to focus the transmitted signal at a desired receive (Rx) location in both space and time. At lower frequency bands, TR in conjunction with array antennas at transmit (Tx) or Rx has been shown to significantly improve its focusing performance relative to the case of single antennas at both link ends. This work for the first time investigates T

In this study we report on the production of metal-hydroxide-coated macroporous polymers (MHCMPs), which mainly involves a polyacrylamide backbone coated with iron-aluminium double hydroxides. The coating process is fast, occurs using relatively mild reagents at room temperature, and can be repeated multiple times, thus making it a very simple and flexible process. Electron microscopy and energy d

Reconstructions of palaeomagnetic secular variation (PSV) in sediment cores can be compared to well-dated regional PSV master curves to infer deposition age. The existing PSV master curve for Fennoscandia, "Fennostack" (Snowball et al., 2007), is limited to the past 10 ka. In this study, we construct a deglacial (for the interval 14-11 ka) PSV master curve for Fennoscandia by including data from a

The common history of Islam and the hip-hop culture can be traced back to the early expression of the culture. Since the early days of hip-hop, Muslims have used hip-hop to convey Islamic messages. Artists driven, in equal parts, by a strong personal belief in Islam and a love for hip-hop music have taken Islamic-themed hip-hop outside its country of birth, the U.S., and have made it into a matter

Specificity and versatility in cyclic AMP (cAMP) signalling are governed by the spatial localisation and temporal dynamics of the signal. Phosphodiesterases (PDEs) are important for shaping cAMP signals by hydrolyzing the nucleotide. In pancreatic beta-cells, glucose triggers sub-plasma-membrane cAMP oscillations, which are important for insulin secretion, but the mechanisms underlying the oscilla

Previous studies have revealed inequalities in stroke treatment based on demographics, hospital type, and region. We used the Swedish Stroke Register (Riksstroke) to test whether patient education level is associated with reperfusion (either or both of thrombolysis and thrombectomy) treatment.

The stochastic Lagrange wave model is a realistic alternative to the Gaussian linear wave model, which has been successfully used in ocean engineering for more than half a century. This paper presents the slope distributions and other characteristic distributions at level crossings for asymmetric Lagrange time waves, i.e. what can be observed at a fixed measuring station, thereby extending result

We study in detail various aspects of the renormalization of the spin-1 resonance propagator in the effective field theory framework. First, we briefly review the formalisms for the description of spin-1 resonances in the path integral formulation with the stress on the issue of propagating degrees of freedom. Then we calculate the one-loop 1(--) meson self-energy within the resonance chiral theor

In response to the 2012 KDIGO (Kidney Disease: Improving Global Outcomes) guideline for blood pressure management in patients with chronic kidney disease not on dialysis, the National Kidney Foundation organized a group of US experts in hypertension and transplant nephrology to review the recommendations and comment on their relevancy in the context of current US clinical practice and concerns. Th

A comprehensive study of the molecular active landscape of human cells can be undertaken to integrate two different but complementary perspectives: transcriptomics, and proteomics. After the genome era, proteomics has emerged as a powerful tool to simultaneously identify and characterize the compendium of thousands of different proteins active in a cell. Thus, the Chromosome-centric Human Proteome

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cogn

OBJECTIVES: To investigate the validity over time of the fingertip-to-floor test (FTF) and the straight leg raising test (SLR) using the Roland Morris Disability Questionnaire (RMDQ) and correlation coefficient (r), and to assess the predictive value of factors related to the change in RMDQ over 12 months using multivariate regression analysis. DESIGN: Longitudinal study. SETTING: Outpatient

Objective. To assess and compare the sensitivity to change of the European League Against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI) with that of other primary Sjogren's syndrome (SS) disease activity indexes. Methods. We abstracted 96 patient profiles, including data on 3 successive visits (visits 1-3), from the medical charts of patients with primary SS. Patient profiles were