Search results

Filter

Filetype

Your search for "*" yielded 540905 hits

Gaia -ESO survey : Lithium abundances in open cluster Red Clump stars

Context. It has recently been suggested that all giant stars with masses below 2 M? suffer an episode of surface lithium enrichment between the tip of the red giant branch (RGB) and the red clump (RC). Aims. We test if the above result can be confirmed in a sample of RC and RGB stars that are members of open clusters. Methods. We discuss Li abundances in six open clusters with ages between 1.5 and

Fusion imaging in brain structure measurements on a fetus phantom, combining real-time ultrasound with magnetic resonance imaging

Objectives: To assess synchronisation of MRI and US in measuring foetus phantom head structures; inter-method, intra- and inter-observer differences on biparietal diameter (BPD), head diameter, anterio-posterior head diameter (HAP) and lateral ventricle structures (VS). Methods: Fusion Imaging (FI) has been performed by combining MRI and US simultaneously. Axial scans of 1.5 Tesla MRI on a foetus

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

Introduction: This study investigated the diagnostic and disease-monitoring potential of plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Methods: Plasma was analyzed using Simoa assays from 99 CU, 107 MCI, and 103 AD dementia participants. Results: Phosphorylated-tau181 (P-tau181), neurofilament light, amyloid-

Personalized prediction of progression in pre-dementia patients based on individual biomarker profile : A development and validation study

Introduction: The prognosis of patients at the pre-dementia stage is difficult to define. The aim of this study is to develop and validate a biomarker-based continuous model for predicting the individual cognitive level at any future moment. In addition to personalized prognosis, such a model could reduce trial sample size requirements by allowing inclusion of a homogenous patient population. Meth

An integrated continuous downstream process with real-time control: A case study with periodic countercurrent chromatography and continuous virus inactivation

Integrated continuous downstream processes with process analytical technology offer a promising opportunity to reduce production costs and increase process flexibility and adaptability. In this case study, an integrated continuous process was used to purify a recombinant protein on laboratory scale in a two-system setup that can be used as a general downstream setup offering multi-product and mult

A method for status determination and risk assessment of energy measures in historic buildings

Implementing energy efficiency measures in historic buildings is a challenging task and require knowledge in a number of different disciplines. The measures to reduce energy use must create a good indoor environment without jeopardizing the loss of important cultural historical values or entailing damages to building materials or load-bearing structures. Building antiquarian-, building biological-

An integrated continuous downstream process with real-time control : A case study with periodic countercurrent chromatography and continuous virus inactivation

Integrated continuous downstream processes with process analytical technology offer a promising opportunity to reduce production costs and increase process flexibility and adaptability. In this case study, an integrated continuous process was used to purify a recombinant protein on laboratory scale in a two-system setup that can be used as a general downstream setup offering multiproduct and multi

Prioritize the right energy measures in historic buildings - Approach and measure selection

The overall energy goals mean that more and more extensive measures need to be applied on buildings with varying degrees of heritage value. Previous studies show that there are a number of measures that have a beneficial impact on different parts of the energy system in historic buildings. What is now needed is a holistic approach that provides an opportunity to prioritize which measures are most

Self-report versus clinician-ratings in the assessment of aggression in violent offenders

Background: The construct of aggression is central to work with violent offenders, but it is a broad construct that can be assessed by many different methods and instruments. Its measurement may, however, have profound implications for treatment planning. We need more knowledge about how different methods for assessing aggression relate to each other. Aims: Our aims were to investigate, first, the

Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer

Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of pat

Naturvetarnas arbetsliv - resultat, utvärdering och slutsatser från alumnenkät 2019

För att öka kunskapen om var studenter med examen i naturvetenskap frånLunds universitet får jobb och hur användbara deras utbildningar är i arbetslivethar vi genomfört en alumnenkät. Alumnenkäten har fokus på interaktionenmellan utbildning och arbetsliv och rör arbete i nära tid efter studierna. Enkätenskickades ut till kandidatalumnerna som tagit ut examen mellan september2017 och september 2018

Foraminiferal Mn/Ca as Bottom-Water Hypoxia Proxy: An Assessment of Nonionella stella in the Santa Barbara Basin, USA

Hypoxia is of increasing concern in marine areas, calling for a better understanding of mechanisms leading to decreasing dissolved oxygen concentrations ([O2]). Much can be learned about the processes and implications of deoxygenation for marine ecosystems using proxy records from low-oxygen sites, provided proxies, such as the manganese (Mn) to calcium (Ca) ratio in benthic foraminiferal calcite,

Does agri-environment scheme participation in England increase pollinator populations and crop pollination services?

Agri-environment schemes are programmes where landholders enter into voluntary agreements (typically with governments) to manage agricultural land for environmental protection and nature conservation objectives. Previous work at local scale has shown that these features can provide additional floral and nesting resources to support wild pollinators, which may indirectly increase floral visitation

Accretion of tidally disrupted asteroids on to white dwarfs : Direct accretion versus disc processing

Atmospheric heavy elements have been observed in more than a quarter of white dwarfs (WDs) at different cooling ages, indicating ongoing accretion of asteroidal material, whilst only a few per cent of the WDs possess a dust disc, and all these WDs are accreting metals. Here, assuming that a rubble-pile asteroid is scattered inside a WD's Roche lobe by a planet, we study its tidal disruption and th

Development and selective grain make plasticity 'take the lead' in adaptive evolution

Background: Biological evolution exhibits an extraordinary capability to adapt organisms to their environments. The explanation for this often takes for granted that random genetic variation produces at least some beneficial phenotypic variation in which natural selection can act. Such genetic evolvability could itself be a product of evolution, but it is widely acknowledged that the immediate sel

Enhancing protein perdeuteration by experimental evolution of Escherichia coli K-12 for rapid growth in deuterium-based media

Deuterium is a natural low abundance stable hydrogen isotope that in high concentrations negatively affects growth of cells. Here, we have studied growth of Escherichia coli MG1655, a wild-type laboratory strain of E. coli K-12, in deuterated glycerol minimal medium. The growth rate and final biomass in deuterated medium is substantially reduced compared to cells grown in ordinary medium. By using

Methodology to obtain highly resolved SO2 vertical profiles for representation of volcanic emissions in climate models

In this study we describe a methodology to create high-vertical-resolution SO2 profiles from volcanic emissions. We demonstrate the method's performance for the volcanic clouds following the eruption of Sarychev in June 2009. The resulting profiles are based on a combination of satellite SO2 and aerosol retrievals together with trajectory modelling. We use satellite-based measurements, namely lida

Building on 150 Years of Knowledge : The Freshwater Isopod Asellus aquaticus as an Integrative Eco-Evolutionary Model System

Interactions between organisms and their environments are central to how biological diversity arises and how natural populations and ecosystems respond to environmental change. These interactions involve processes by which phenotypes are affected by or respond to external conditions (e.g., via phenotypic plasticity or natural selection) as well as processes by which organisms reciprocally interact