Increasing evidence links intraneuronal β-amyloid (Aβ 42) accumulation with the pathogenesis of Alzheimer's disease (AD). In Aβ precursor protein (APP) mutant transgenic mice and in human AD brain, progressive intraneuronal accumulation of Aβ42 occurs especially in multivesicular bodies (MVBs). We hypothesized that this impairs the MVB sorting pathway. We used the trafficking of the epidermal grow

Molecular chaperones and their functions in protein folding have been implicated in several neurodegenerative diseases, including Parkinson's disease and Huntington's disease, which are characterized by accumulation of protein aggregates (e.g., α-synuclein and huntingtin, respectively). These aggregates have been shown in various experimental systems to respond to changes in levels of molecular ch

Objective: It is postulated that increased load from pinch and grasp in occupational tasks increases the risk of thumb carpometacarpal (CMC1) osteoarthritis (OA). We sought to characterise the relationship between doctor-diagnosed CMC1 OA and occupation in a large working population. Methods: We performed a matched case-control study using a Swedish healthcare register. We identified residents age

Laser Shock Peening (LSP) and Shot Peening (SP) are processes used to mechanically alter the surface properties of metals by inducing a transient high-pressure wave by a laser pulse or by a high-velocity impact of a peening particle. Both processes aim to induce compressive residual stresses near the surface and the level of residual stresses obtained from SP or LSP is similar. When austenitic steLaser Shock Peening (LSP) and Shot Peening (SP) are processes used to mechanically alter the surface properties of metals by inducing a transient high-pressure wave by a laser pulse or by a high-velocity impact of a peening particle. Both processes aim to induce compressive residual stresses near the surface and the level of residual stresses obtained from SP or LSP is similar. When austenitic ste

Biografisk artikel om skådespelaren Inga Tidblad i Svenskt kvinnobiografiskt lexikon

There is no apparent need for individuals to endure this kind of suffering in contemporary Western society with all its advantages. Nevertheless, endurance running is now a mainstream leisure pursuit. Why do hundreds of thousands of men, women and even children choose this torturous kind of leisure activity?In previous literature on consumption of extraordinary experiences, authors focus on the pu

The use of the structural similarity index (SSIM) is widespread. For almost two decades, it has played a major role in image quality assessment in many different research disciplines. Clearly, its merits are indisputable in the research community. However, little deep scrutiny of this index has been performed. Contrary to popular belief, there are some interesting properties of SSIM that merit suc

Vi möter våld i någon form dagligen, om inte som ”offer” eller ”förövare”, så när vi läser tidningen, tittar på tv eller går på bio. Med våld upprätthålls stater, grupphierarkier och individuella maktpositioner. Första upplagan av Våldets kön utkom 2015 men de utmaningar som våldet innebär för samhället har inte minskat sedan dess. I denna reviderade och utökade upplaga uppmärksammas ”nya” former