Objective: Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaque

Making an accurate Radio Frequency, RF, design of any accelerating structure is fundamental to ensure that electromagnetic and beam dynamics requirements will be achieved. This is essential for the most complicated accelerating structureslike the Drift Tube Linac, DTL; in this case a meticulous design facilitates the RF commissioning too. In this paper the influence of the interfaces and of the fi

Mantle cell lymphoma (MCL) is a rare, aggressive, incurable B-cell malignancy. Ibrutinib has been shown to be highly active for patients with relapsed/refractory (R/R) MCL. The RAY trial (MCL3001) was a phase 3, randomized, open-label, multicenter study that compared ibrutinib with temsirolimus in patients with R/R MCL. Active disease is frequently associated with impaired functional status and re

Software engineers working in large projects must navigate complex information landscapes. Change Impact Analysis (CIA) is a task that relies on engineers' successful information seeking in databases storing, e.g., source code, requirements, design descriptions, and test case specifications. Several previous approaches to support information seeking are task-specific, thus understanding engineers'

Tunneling field-effect transistors (TunnelFET), a leading steep-slope transistor candidate, is still plagued by defect response, and there is a large discrepancy between measured and simulated device performance. In this work, highly scaled InAs/InxGa1−xAsySb1‑y/GaSb vertical nanowire TunnelFET with ability to operate well below 60 mV/decade at technically relevant currents are fabricated and char

African trade statistics suffer from errors of commission and omission. A quarter-century ago, Alexander Yeats (1990) compared receipts of importers and exporters and concluded that the data could not be used to determine the magnitude, direction, or composition of trade. The only fact to be safely deduced from the evidence was that the statistics were plagued by widespread smuggling and/or underr

The quality of economic statistics in Africa has been likened to a statistical tragedy. Currently many statistical systems in Africa are being updated. This report from the statistical offices in Nigeria, Liberia and Zimbabwe documents that base year, data and methods used to generate GDP estimates currently date from 1990, 1992 and 1994. There is a growing need for macroeconomic statistics, but a

Coordinating aid distribution to the poorest countries requires identifying which countries are poor. In practice this has meant sorting countries into developmental cohorts on the basis of macroeconomic data, with countries in poorer cohorts gaining access to more and more concessional aid programs. To the extent that governments can influence their macroeconomic data, some, especially those in a

Aim: To investigate how day center attendees with psychiatric disabilities perceived their worker role and the importance of current work situation and personal factors in that respect. Methods: Two-hundred attendees completed the Worker Role Self-assessment and questionnaires addressing possible predictors of the worker role: current employment situation, satisfaction with that situation, and a p

Measurement is increasingly at the centre of debates in African economic development. Some remarkable upward revisions of GDP, which are signs of statistical systems improving, caused the declaration of a statistical tragedy in Africa. This special issue evaluates the database for African economic development with articles on the quality of the data on GDP, health and education, poverty, labour, a