It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study sh

Popular Abstract in Swedish Syftet med denna undersökning är att diskutera inlärares signaler om hjälp att uttrycka sig på främmande språk, här franska, signaler som här kallas ?sollicitationer?. Undersökningen handlar om vilken roll dessa spelar för den fortsatta utvecklingen av samtalet med den infödde talaren, närmare bestämt för att utlösa s.k. SPA (Séquences Potentiellement Acquisitionnelles)The aim of this study is to discuss how ?soliciting? (non-native speakers? requests of native speakers for help in how to express themselves in a foreign language) may play a part in the triggering of SPAs (Séquences Potentiellement Acquisitionnelles or ?learning?teaching sequences?). The beneficial effect of SPAs for learning is still controversial, since no correlation has yet been shown between

Seventeen patients with sciatica and isthmic lumbar spondylolisthesis were studied with magnetic resonance (MR) imaging. In 13, myelography was also performed: 5 had dural sac deformation and root sleeve shortening, 2 had deformation with unilateral root sleeve shortening, one had bilateral root sleeve shortening only, and one had sac deformation only. In 4, myelography was normal. On sagittal MR

Purpose: To investigate the findings in optical coherence tomography (OCT) in eyes with metamorphopsia after scleral buckling surgery for macula-off retinal detachment. Methods: A total of 46 patients (46 eyes) with macula-off retinal detachment were prospectively studied 2 months after successful scleral buckling surgery. Patients were examined with the Amsler grid, fundus biomicroscopy and OCT.

Background: Pancreatic acinar-like metaplasia has previously been described in the gastric mucosa and in the distal part of the oesophagus. The resemblance to pancreatic acinar cells prompted us to study the possible occurrence of secretory pancreatic proteins in these cells. Methods: Seven specimens obtained from the distal oesophagus at gastroscopy where routine microscopy showed pancreatic acin

Abstract in UndeterminedBackground Cigarette smoking is known to impede bone healing. The hemicallotasis technique is based on an external fixation and delayed healing prolongs treatment and increases the risk of further complications. Patients and methods 200 patients, 34 smokers and 166 nonsmokers, operated on by the hemicallotasis technique in the proximal tibia for deformities of the knee (kne

We describe a test which uses the ability of viable cells to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to detect resistance to a bactericidal drug, rifampin, in in vitro-cultured Mycobacterium tuberculosis. The assay shows a linear relationship between the number of viable bacteria and the ability to reduce MTT. Dead mycobacteria were unable to reduce MTT. Rifampin

PURPOSE: To report a case of aortoenteric fistula secondary to endovascular abdominal aortic aneurysm (AAA) exclusion using the Stentor bifurcated endovascular graft. METHODS AND RESULTS: Seventeen months after a successful endovascular AAA procedure, a male patient developed upper gastrointestinal bleeding. An aortoenteric fistula was diagnosed. At operation, the endograft fabric was found to be

The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.

Glycosylation and sulfation are two of the essential post-translational modifications of proteins. The slalom gene encodes a 3'-phosphoadenosine 5'-phosphosulfate transporter, a conserved protein found in organisms as diverse as plants and humans and required for sulfation of proteins. In Drosophila, slalom is exclusively expressed in salivary glands, which is unexpected, taken into account the ge

Popular Abstract in Swedish Avhandlingen består av en inledning och 4 artiklar. Den första artikeln, Young people and alcohol: an econometric analysis, analyser bestämningsfaktorerna för ungdomars konsumtion av alkohol ur ett hälsoekonomiskt perspektiv. Huvudresultatet i artikeln är att ungdomar som har föräldrar som är villiga att tillhandahålla alkohol till dem är mer benägna att dricka alkohol,This thesis consists of four essays on risky health behaviour among adolescents. In the first paper, Young people and alcohol: an econometric analysis, the purpose was to analyse the determinants of adolescent drinking behaviour within an economic-theoretical framework. The results showed that having parents willing to supply alcohol increased the frequency of beer-, wine-, and spirits-consumption

Abstract is not available

Utilisation of 'omics' technologies, in particular gene expression profiling, has increased dramatically in recent years. In basic research, high-throughput profiling applications are increasingly used and may now even be considered standard research tools. In the clinic, there is a need for better and more accurate diagnosis, prognosis and treatment response indicators. As such, clinicians have l

In the current thesis, the neurogenic and angiogenic response to electroconvulsive seizure (ECS)-treatment was investigated in the adult rat brain. ECS-treatment is an animal model for the antidepressant treatment electroconvulsive therapy (ECT), which is considered to be the most effective antidepressant treatment modality today, however with not yet fully understood modes of action. Depression,

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A new experimental technique to measure stopping forces for swift heavy ions was tested and has been found effective. A commercial PIN photodiode was coated with a patterned stopping medium of gold. This allowed the simultaneous detection of stopped- and reference-ions of C-14 and N-14 in the energy range E = 6.4-10.4 MeV. The stopping forces of these ions in gold have been measured with excellent