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Resveratrol (Res) is a specific agonist of sirtuin 1, and has many cardioprotective effects. Although Res is able to relax various vascular beds, its pharmacological properties in rat superior mesenteric arteries and the underlying mechanism are not well clarified. The aim of present study was to investigate the vasorelaxant effects of Res on rat superior mesenteric arteries and the mechanisms inv

MapReduce has become the standard model for supporting big data analytics. In particular, MapReduce job optimization has been widely considered to be crucial in the implementations of big data analytics. However, there is still a lack of guidelines especially for practitioners to understand how the MapReduce jobs can be optimized. This paper aims to systematic identify and taxonomically classify t

Objectives: To describe the housing situation and aspects of participation among older adults living with long-standing spinal cord injury (SCI) with attention to SCI severity, and to examine whether and how objective housing accessibility (based on objectively measurable criteria) is associated with aspects of participation. Design: Cross-sectional study utilizing the assessment tools Impact on P

Secondary objectives:Secondary objectives:P Primary objective: To assess whether head midline position compared with any other head position is more effective in prevention or extension of germinal matrix-intraventricular hemorrhage in infants born at ≤ 32 weeks' gestational age. Secondary objectives: To perform subgroup analyses regarding gestational age, birth weight, intubated versus not intuba

We introduce a new technique for the design of an output combiner for Doherty power amplifier (DPA) and its effective exploitation for the development of a wideband laterally diffused metal oxide semiconductor (LDMOS) DPA. The design is enabled by a two-line impedance inverter for the DPA back-off operation, which is capable of 52% of fractional bandwidth. The technique is validated by the develop

Background: Sonographers' perceptions of ergonomic and work-related pain problems at work have so far mostly been researched in quantitative studies by questionnaires. There is a need of experience-based research to deepen the knowledge about how sonographers perceive ergonomic problems at work. Therefore, the aim of this qualitative study was to describe sonographers' perceptions of ergonomic pro

We analyze femtosecond supercontinuum generation in a distribution of thin solid plates to show that the distributed scheme inhibits processes leading to pulse breakup while allowing spectral expansion to proceed as desired. We introduce basic criteria for setting the plate thickness or initial laser intensity and the location of each plate in the laser beam path and confirm that under these condi

Surface water is vital for Swedish drinking water supply. In the past decades, a trend of increased total organic carbon (TOC) concentrations has led to higher consumption of coagulants in drinking water treatment, and has pushed the levels in the outgoing water closer to the allowed levels of TOC. Also, two occasions of cryptosporidium outbreaks in northern Sweden have stressed the importance of

Aims/hypothesis: Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming adipose tissue dysfunction in LBW individuals. Methods: ADSCs were isolated from the subcutaneous adipose tissue of 13 normal birthw

Background: In 2014 the Swedish government assigned to The Public Health Agency of Sweden to conduct studies to evaluate optimal use of existing antibiotic agents. The aim is to optimize drug use and dosing regimens to improve the clinical efficacy. The present study was selected following a structured prioritizing process by independent experts. Methods: This phase IV study is a randomized, open-

BACKGROUND AND PURPOSE—: Patient selection in clinical trials on intracerebral hemorrhage (ICH) affects overall applicability of results. We estimated eligibility for completed, ongoing, and planned clinical trials in an unselected cohort of patients with ICH. METHODS—: Large clinical ICH trials were identified using trial registration databases. Each trial’s inclusion criteria were applied to a c

This intervention briefly goes through two schemes that allocate asylum-related responsibilities between states: the Dublin mechanism within the EU and the EU-Turkey statement. By identifying their flaws, the paper suggests that although solidarity has been invoked as a response to the so-called “refugee crisis”, the way it has been conceptualised makes it part of the problem.

This paper is about line search for the generalized alternating projections (GAP) method. This method is a generalization of the von Neumann alternating projections method, where instead of performing alternating projections, relaxed projections are alternated. The method can be interpreted as an averaged iteration of a nonexpansive mapping. Therefore, a recently proposed line search method for su

Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors. Mutant studies, structural analysis, and molecular modeling revealed that the coumaryl substituents stack onto arginine side chains. One inhibitor displayed efficacy in a murine model of bleomycin-induced lung fibrosis

Synaptic dysfunction may represent an early and crucial pathophysiology in Alzheimer's disease (AD). Recent studies implicate a connection between synaptic plasticity deficits and compromised capacity of de novo protein synthesis in AD. The mRNA translational factor eukaryotic elongation factor 1A (eEF1A) is critically involved in several forms of long-lasting synaptic plasticity. By examining pos