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Automated analysis of song structure in complex birdsongs

Understanding communication and signalling has long been strived for in studies of animal behaviour. Many songbirds have a variable and complex song, closely connected to territory defence and reproductive success. However, the quantification of such variable song is challenging. In this paper, we present a novel, automated method for detection and classification of syllables in birdsong. The meth

Planet population synthesis driven by pebble accretion in cluster environments

The evolution of protoplanetary discs embedded in stellar clusters depends on the age and the stellar density in which they are embedded. Stellar clusters of young age and high stellar surface density destroy protoplanetary discs by external photoevaporation and stellar encounters. Here, we consider the effect of background heating from newly formed stellar clusters on the structure of protoplanet

The ALICE transition radiation detector: Construction, operation, and performance

The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of t

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes : A prospective study in children

Background: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can imp

Regional innovation systems and global flows of knowledge

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

Impact of current localization on the performance of compact MIMO antennas

In this paper, we study the influence of current localization on the isolation between two antennas in a compact terminal setting. The two antennas are chosen to be a monopole and a PIFA. The degree of current localization is controlled by the permittivity value of the PIFA’s dielectric loading. Both lossless and lossy cases are simulated in order to ascertain the underlying performance impact fro

Gut Feelings - From Brain to Gut and from Lumen to Gut

Part 1: From Brain to GutThe brain is an organ with a high energy requirement. To meet this demand, the brain needs a continuous and well-regulated blood supply. In situations where the brain, or parts of the brain, does not receive sufficient blood flow injury arise. This condition, commonly known as cerebral ischemia, is prevalent in today's society. In 2015, more than 6 million people died from

Clinical implications of CT findings in mesenteric venous thrombosis at admission

Purpose: The main aim of this study was to evaluate the association of computed tomography (CT) findings at admission and bowel resection rate in patients with mesenteric venous thrombosis (MVT). It was hypothesized that abnormal intestinal findings on CT were associated with a higher bowel resection rate. Methods: Retrospective study of MVT patients treated between 2004 and 2017. CT images at adm

Overweight, obesity and the risk of LADA : results from a Swedish case–control study and the Norwegian HUNT Study

Aims/hypothesis: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly s

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in a range of disorders. Here, we generalize the strategy used to probe free-energy landscapes in protein f

ALPPS Improves Resectability Compared with Conventional Two-stage Hepatectomy in Patients with Advanced Colorectal Liver Metastasis : Results from a Scandinavian Multicenter Randomized Controlled Trial (LIGRO Trial)

Objective: The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage hepatectomy (TSH) in a randomized controlled trial (RCT). Background: Radical liver metastasis resection offers the only chance of a cure for patients with metastatic colorectal cancer. Patients with colo

Revisiting the Origin of the Vertebrate Hox14 by Including Its Relict Sarcopterygian Members

Bilaterian Hox genes play pivotal roles in the specification of positional identities along the anteroposterior axis. Particularly in vertebrates, their regulation is tightly coordinated by tandem arrays of genes [paralogy groups (PGs)] in four gene clusters (HoxA-D). Traditionally, the uninterrupted Hox cluster (Hox1-14) of the invertebrate chordate amphioxus was regarded as an archetype of theve

The African coelacanth genome provides insights into tetrapod evolution

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the

Numerical modeling of the coupled feedback between pool fires and their environment

Computational fluid dynamics (CFD) is often used within performance based fire safety engineering and its use has increased as available computational power has increased. However, there is still a need to improve CFD modeling to push it beyond its current usage limitations. Of course such steps must be accompanied by quality assurance by means of validation and verification. In this thesis three

Responses of microbial tolerance to heavy metals along a century-old metal ore pollution gradient in a subarctic birch forest

Heavy metals are some of the most persistent and potent anthropogenic environmental contaminants. Although heavy metals may compromise microbial communities and soil fertility, it is challenging to causally link microbial responses to heavy metals due to various confounding factors, including correlated soil physicochemistry or nutrient availability. A solution is to investigate whether tolerance

Lidar mapping of atmospheric atomic mercury in the Wanshan area, China

A novel mobile laser radar system was used for mapping gaseous atomic mercury (Hg0) atmospheric pollution in the Wanshan district, south of Tongren City, Guizhou Province, China. This area is heavily impacted by legacy mercury from now abandoned mining activities. Differential absorption lidar measurements were supplemented by localized point monitoring using a Lumex RA-915M Zeeman modulation merc

Organic management and cover crop species steer soil microbial community structure and functionality along with soil organic matter properties

It is well recognized that organic soil management stimulates bacterial biomass and activity and that including cover crops in the rotation increases soil organic matter (SOM). Yet, to date the relative impact of different cover crop species and organic vs. non-organic soil management on soil bacteria and fungi and on SOM quantity and quality remains to be tested. We used a long-term (10 years) fu

Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension

Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated T