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Association of oestrogen receptor alpha gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone

BACKGROUND: The gene encoding oestrogen receptor alpha (ESR1) appears to regulate bone mineral density (BMD) and other determinants of osteoporotic fracture risk.OBJECTIVE: To investigate the relation between common polymorphisms and haplotypes of the ESR1 gene and osteoporosis related phenotypes in a population based cohort of 3054 Scottish women.RESULTS: There was a significant association betwe

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

BACKGROUND: Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type Ialpha1, a bone-matrix protein.METHODS: We determined the COLIA1 genotypes SS, Ss, and ss in a population-based sample of 1778 postmenopausal women using a polymerase-chain-reaction-based assay. We the

Total Synthesis of Dehaloperophoramidine : Evolution of a Synthesis

This account describes our efforts toward developing a stereodivergent entry to perophoramidine and the communesin alkaloids. The original approach toward our simplified model substrates relied on a palladium-catalyzed carbopalladation–carbonylation of a tetrasubstituted olefin to install the vicinal all-carbon quaternary stereocenters present in the target molecules, the olefin's stereochemistry

Generation of Ultrashort Pulses – From Femtoseconds to Attoseconds

Electronic dynamics takes place on the attosecond timescale and can thus only be studied using a tool with attosecond temporal resolution. High harmonic generation (HHG) provides coherent attosecond pulses in the extreme ultraviolet spectral region. The work presented in this thesis focuses on generating and characterizing ultrashort femtosecond pulses and using them for HHG, together with a gatin

Developing a method for driving the solar control mechanism selection

A method was developed, which drives the selection of appropriate solar control mechanisms based on theanalysis of overheating due to solar heat gains. The aim of the method is to maintain adequate thermalcomfort levels in highly glazed spaces. Two thermal comfort models, Predicted Mean Vote and AdaptiveModel, were chosen to set the thermal comfort boundaries included in the method. Moreover, in o

Modeling of a solar dryer for fruit preservation in developing countries

About 25,3 % of the Mozambican population is suffering from undernourishment even though a sufficient amount of food and specifically fruits are produced. Post-harvest losses are estimated to 25 % to 40 % and part of the production is not even harvested due to a short season. A solution has to be found to improve fruit preservation and allow the population to consume what is harvested later. Dryin

What Happens to Nordic Culture When you Drop the “Heritage"? : Re-imagining Nordic culture for a new museum.

In the last decade, museums that were established in the 20th century by immigrants from the five Nordic countries have become increasingly concerned with broadening their audiences and more actively engaging their visitors. Efforts to do this have varied from offering traveling exhibitions produced in the Nordic countries, film programs, festivals, concert series, cocktail hours, culinary confere

First optics and beam dynamics studies on the MAX IV 3 GeV storage ring

The MAX IV 3 GeV storage ring is the first light source to make use of a multibend achromat lattice to reach ultralow emittance. After extensive commissioning efforts, the storage ring is now ramping up its user program. We present results from beam commissioning of the MAX IV 3 GeV storage ring as well as a summary of the beam dynamics studies that have so for been carried out. We report on injec

Nation branding and the social imaginary of participation : An exploratory study of the Swedish Number campaign

The Swedish Number is a 2016 marketing campaign by an independent tourist association that relies heavily on a developing heritage of Swedish nation branding initiatives. It uses media technologies to encourage citizen participation in promoting Swedish values, partly for the purpose of showing the country’s authentic side and partly for generating publicity. This article conducts a case study of

Cross-sectional comparative study of risky sexual behaviours among HIV-infected persons initiated and waiting to start antiretroviral therapy in rural Rakai, Uganda

Objectives To compare risky sexual behaviours between HIV-positive persons initiated on antiretroviral therapy (ART) (ART-experienced) and persons waiting to start on ART (ART-naive) and assess predictors of risky sexual behaviours among HIV-infected patients in rural Rakai district, Uganda. Study design This is a cross-sectional study that used data from the Rakai Community Cohort Study (RCCS) da

ONSHORE WINDMILL FOUNDATIONS - Evaluation of new proposals

Windmill structures must withstand very high horizontal loading giving an extremely large overturning moment on the foundation. These structures have very low stability loads in comparison to the overturning loads. The traditional way to solve the construction problem uses a shallow foundation with a massive concrete volume or a piled foundation to resist the extreme overturning moment. This work