M proteins and M-like proteins, expressed on the surface of group A streptococci and binding to human plasma proteins, can be divided into two classes, A and C, depending on the structure of the central repeated regions. The class C proteins have been shown to be dimers with a coiled-coil structure. In this work, we have compared the structure and binding of a class A protein, Mrp4, and a class C

Existing bag-model calculations for the masses of lowest-lying glueball states are extended and reviewed and compared to the present lattice Monte Carlo calculations. The predicted spectra agree remarkably well.

Methods for computing loop diagrams in confined scalar and gauge theories are developed. We construct propagators with different types of boundary conditions in boxes (rectangular cavities) using the method of image charges, which allows for a separation of the short-distance singularities. The techniques are illustrated by a calculation of the Casimir effect in a box using a covariant gauge, and

The first experimental measurements of intense laser-driven terahertz (THz) radiation from a solid target which is preheated by an intense pulse of laser-accelerated protons is reported. The total energy of the THz radiation is found to decrease by approximately a factor of 2 compared to a cold target reference. This is attributed to an increase in the scale length of the preformed plasma, driven

The tidal field of galaxies is known generally to be disruptive. However, in the case of galaxy mergers, a compressive mode of tidal wave may develop and last long enough to cocoon the formation of star clusters. Using an N‐body simulation of the Antennae galaxies, we derive the positions of these compressive regions and the statistics of their duration. Excellent agreement between the spatial dis

We present a novel and flexible tensor approach to computing the effect of a time-dependent tidal field acting on a stellar system. The tidal forces are recovered from the tensor by polynomial interpolation in time. The method has been implemented in a direct-summation stellar dynamics integrator (NBODY6) and test-proved through a set of reference calculations: heating, dissolution time and struct

New high-flux and high-brilliance neutron sources demand a higher count-rate capability in neutron detectors. In order to achieve that goal, the Solid-State Neutron Detector (SoNDe) project is developing a scintillation-based neutron detector. It will be capable of fully exploiting the available flux at small-angle neutron scattering (SANS) instruments at high brilliance sources, such as SKADI at

Background: To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function. Methods: Post hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of sponta

Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 7

Background: Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues adjacent to the tumour in Burkitt lymphoma patients. Here we present a patient

Alpha1-microglobulin (alpha1m) is a small glycoprotein with immunomodulatory properties. It is a member of the lipocalin family, a group of proteins that exhibit a well-conserved three-dimensional structure despite low sequence identity and that are known to bind small hydrophobic ligands. The types of ligands carried by alpha1m are still unknown, but it is known that this protein has yellow-brown

The human plasma protein alpha1-microglobulin (alpha1m) was found to inhibit the antigen-induced interleukin-2 (IL-2) production of two different mouse T-helper cell hybridomas. Alpha1m isolated from human plasma and recombinant alpha1m isolated from baculovirus-infected insect cell cultures had similar inhibitory effects. Flow cytometric analysis showed a binding of plasma and recombinant alpha1m

alpha 1-Microglobulin, a plasma protein with immunoregulatory properties, and bikunin, the light chain of the proteinase inhibitors inter-alpha-inhibitor and pre-alpha-inhibitor, are translated as a precursor protein from the same mRNA. The cosynthesis of alpha 1-microglobulin and bikunin is unique compared to other proproteins such as procomplement components and prohormones, since alpha 1-microg