Background: Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results indicate effect of low-dose tamoxifen therapy. Using questionnaire data from a randomised controlled trial, we describe side effects of standard and low-dose tamoxifen in healthy women. Methods: In the KARISMA trial, 1440 healthy women were randomised to

Forced cross-border migration and entrepreneurship have persisted as perennial themes throughout the annals of human history. However, the recent ‘refugee crisis’ has sparked a resurgence of interest in their interplay under the rubric of ‘refugee entrepreneurship’. While its territory is not entirely uncharted, a surge in scholarly urgency and heightened scientific production have significantly e

Silicon (Si) phases such as biogenic silica, lithogenic silicate and authigenic silica/silicate in marine sediments provide valuable information about past Si cycling. Wet-chemical sequential leaching methods are often applied to extract different Si phases from marine sediments to study Si diagenetic processes in shallow subsurface. The potential of this method to separate Si phases from deeply-b

Adolescent mothers face numerous challenges. This study aimed to address the operationalisation of the new South African national policy for young mothers by testing the associations of potential protective provisions with three policy goals: School return, grade promotion, and pregnancy/HIV prevention. Adolescent mothers aged 12–24 from rural and urban communities of South Africa’s Eastern Cape c

Objectives: To evaluate the total number of false-positive recalls, including radiographic appearances and false-positive biopsies, in the Malmö Breast Tomosynthesis Screening Trial (MBTST). Methods: The prospective, population-based MBTST, with 14,848 participating women, was designed to compare one-view digital breast tomosynthesis (DBT) to two-view digital mammography (DM) in breast cancer scre

This chapter investigates how reports in Swedish mainstream media framed the 1980s peace movement collective actions in Sweden. By revisiting press coverage of protest events, the analysis identifies the central characteristics of the framing. Primarily, the protests are found to be framed in positive terms and successfully conveyed what Charles Tilly and others have noted as key for a social move

The Winter Palace (TWP) was a venue and association within the left-wing alternative environment in Malmö between 1987–1989, with premises in the port area. The venue ran a pub and café; arranged concerts, public lectures, and movie screenings; broadcasted radio; published fanzines; and more. The idea was that the proceeds would be used to build a Southern Swedish center for anarchist propaganda a

We investigated 390 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated according to NOPHO ALL 2008, regarding copy number alterations (CNA) of eight loci associated with adverse prognosis, including IKZF1. The impact on outcome was investigated for each locus individually, combined as CNA profiles and together with cytogenetic information. The presence of IKZF1 de

This study investigated the effect of autonomy-supportive parenting practices on young adolescents’ self-reported motivation to defend victims of bullying, and the possible mediating effects of factors such as reactance, anxiety, depression, and stress. Methods: Data were collected from 578 Italian public school students ages 10–14 (Mage = 11.8 years, 52% boys), who completed a survey in their cla

Background: Oxytocin is routinely administered after delivery for prophylaxis and treatment of postpartum hemorrhage, but it is associated with considerable cardiovascular side-effects. Carbetocin, a synthetic oxytocin analogue, has a myometrial contraction effect of 60 min when given IV, compared with 16 min for oxytocin. Objective: To investigate whether there are differences in cardiovascular e

INTRODUCTION: β-Synuclein is an emerging synaptic blood biomarker for Alzheimer's disease (AD) but differences in β-synuclein levels in preclinical AD and its association with amyloid and tau pathology have not yet been studied. METHODS: We measured plasma β-synuclein levels in cognitively unimpaired individuals with positive Aβ-PET (i.e., preclinical AD, N = 48) or negative Aβ-PET (N = 61), Aβ-po

To avoid the scaling of the number of qubits with the size of the basis set, one can divide the molecular space into active and inactive regions, which is also known as complete active space methods. However, selecting the active space alone is not enough to accurately describe quantum mechanical effects such as correlation. This study emphasizes the importance of optimizing the active space orbit

Non-technical summary The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of soci

Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the e

Behovet av att ersätta konventionell fossilbaserad plast blir allt viktigare. Eftersom klimatförändringarna mer synligt påverkar vårt samhälle, förvärrar det problemet att använda icke-hållbara resurser för att tillverka plast. Dessutom hamnar dessa långvariga, icke-återvunna avfall i våra hav, vilket skapar ett inneboende miljöföroreningsproblem. Att forska om nya biobaserade byggstenar för att mThe need to replace conventional fossil-based plastics is becoming more imperative. As climate change is more visibly affecting our society, employing non-sustainable resources to produce plastics is aggravating the problem. Moreover, these long-lasting, non-recycled wastes end up in our oceans, creating an intrinsic environmental pollution problem. Researching new biobased building blocks to enab

Due to desirable optical properties, such as efficient luminescence and large Stokes shift, DNA-templated silver nanoclusters (DNA-AgNCs) have received significant attention over the past decade. Nevertheless, the excited-state dynamics of these systems are poorly understood, as studies of the processes ultimately leading to a fluorescent state are scarce. Here we investigate the early time relaxa

Background: Insulin resistance has been shown to be related to a higher risk of several cancers, but the association with prostate cancer (PCa) has been inconsistent. Methods: We investigated prediagnostic markers of insulin resistance in men in four cohorts in Sweden, in relation to PCa risk (total, non-aggressive and aggressive) and PCa death using multivariable-adjusted Cox regression. The numb