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Background and objective: Clinical and experimental studies have revealed a central role of calcitonin gene-related peptide (CGRP) in primary headaches. The role of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in neuronal and glial cell expression of CGRP- immunoreactivity (-ir) in rat trigeminal ganglia was studied with an organ culture method. Experimental procedures: Sections of adult

Introducing a new way of visualizing cDNA microarray data we have identified a new type of systematic variation, which we refer to as plate effects. We believe that plate effects are due to non-biological differences in the cDNA clones products spotted onto the microarray slides. By comparing the consistency of all replicates (both within and between slides) after performing 42 different normaliza

This article reports a series of model experiments where tense vowel configurations were transformed in steps to lax configurations in order to estimate the contribution of each articulator to the spectral contrast. Traditionally, the contrast of tenseness in vowels has been associated with the degree of constriction of the passage between the tongue arch and the palate and with vowel quantity, bo

Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we ca

Discusses how a series of artefacts became important for cultural processes in a Swedish IT company during a turbulent period in business - a period that was known as "the new economy".

Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing.

Preservatives are widely used to prevent microbial growth both for skin care products and in the industry. Many of them have allergic potential. Allergic contact dermatitis caused by preservatives can often be chronic, probably because it is difficult to suspect contact allergy to these chemicals based on the patient's history only. Formaldehyde is a common cause of contact allergy and has been in

RATIONALE AND OBJECTIVES. The authors evaluate the feasibility of differential imaging of contrast media, with division of individual pixel values obtained from digital images generated by characteristic radiation from a laser-produced plasma, bridging the K-absorption edge of the contrast agent. METHODS. Laser pulses from an ultrashort-pulse terawatt laser system were focused onto gadolinium and

Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as

PURPOSE: The objective was to estimate health care costs and productivity losses due to epilepsy in Sweden and to compare these estimates to previously published estimates. METHODS: Register data on health care utilisation, pharmaceutical sales, permanent disability and mortality were used to calculate health care costs and costs that accrue due to productivity losses. By linkage of register info

The hypothesis was that some occupations could lead to preterm birth (PTB) because of potential exposures to various agents. The objective in this nationwide follow-up study was to analyse the association between PTB and parental occupational groups, controlling for potential confounders. Data from the Swedish Medical Birth Register, in which all children born in Sweden from 1990 onward are regist

AIM: The cholesterol-lowering properties of oats, largely ascribed to its contents of soluble fibers, beta-glucans, are well established, whereas effects on atherogenesis are less well elucidated. Oats also contains components with reported antioxidant and anti-inflammatory effects that may affect atherogenesis. In this work we examined effects of oat bran on plasma cholesterol, markers of inflamm

The mechanisms of neutral dissociation of oxygen molecules in the excitation energy range 15–25 eV have been studied in a dispersed fluorescence experiment. By detecting the fluorescence from excited oxygen atoms, we find that neutral superexcited O2 states below 20 eV dissociate into O(g.s.)+O(3s,3p). At higher excitation energies (hν=20–25 eV) the curve-crossing interactions following excitation