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Human a-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of the interaction between protein and OA moieties, charge-specific chemical modifications of lysine side chains involving citraconylation, acetylation, and

Background: Approximately 20% of patients with bipolar disorder experience mixed states. Mixed states are associated with more comorbidity, poorer treatment response and prognosis, increased relapse rate, and decreased functioning. This study aimed to produce in-depth knowledge about bipolar patients' quality of life (QoL) and functioning related to mixed states. Sampling and Methods: This study u

Evidence-based medicine (EBM) uses the current best evidence to inform decisions about care of individual patients, healthcare procedures, and technologies. The "gold standard" for optimal evidence in the Cochrane system is Level I randomized, controlled trials (RCTs) and meta-analyses of several RCTs. In order to achieve this level of evidence, one of the most important measures is the use of out

INTRODUCTION: Bisphosphonates have been shown to reduce osteoclastic activity and enhance pin fixation in both experimental and clinical studies. In this prospective, randomized study of high tibial osteotomy using the hemicallotasis (HCO) technique, we evaluate whether treatment by one single infusion of zoledronic acid can enhance the pin fixation. MATERIALS AND METHODS: 46 consecutive patients

The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic ce

This thesis explores the impact of past and present landscape and habitat structure on present levels of vascular plant species diversity within fragmented semi-natural grasslands. Within the Jordtorp-area, a mosaic agricultural landscape on the island of Öland (Sweden), historical land-use changes and the development of semi-natural grasslands was characterized, over a time-period of almost 300 y

A tree-ring-width chronology of Pinus tabulaeformis from Kalaqin, Inner Mongolia was developed using modern dendrochronological techniques. Based on the results of correlation function analysis, the total precipitation from the previous August to current July was reconstructed for 1771-2008 AD with an explained variance of 49.3%. The reconstruction correlated well with the dryness/wetness series d

Review of Owe Ronström, “Kulturarvspolitik. Visby från sliten småstad till medeltidsikon” (Stockholm 2008).

We applied a hybrid approach to estimate the benchmark dose (BMD) and the lower 95% confidence limit (BMDL) for cadmium-induced bone effects in a population with low environmental exposure. Morning urine samples were collected by 794 Swedish women, aged 53-64 years, participating in a population-based study We measured urinary cadmium (U-Cd), a marker of long-term exposure, and bone mineral densit

Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. Accumulating epidemiological evidence suggests that obesity is a risk factor for CRC in particular in men, as weak or no associations are seen in wom

We establish a sufficient condition ensuring strong Hellinger consistency of posterior distributions. We also prove a strong Hellinger consistency theorem for the pseudoposterior distributions based on the likelihood ratio with power 0 < alpha < 1, which are introduced by Walker and Hjort [2001 'On Bayesian Consistency', J. R. Statist. Soc., B 63, 811-821]. Our result is an extension of their theo

I antologin får du ta del av sju olika analyser av det utmanande arbetet med att åstadkomma inriktning och samordning av samhällets resurser i samband med skogsbranden. Publikationen är ett utvecklingsbidrag och är tänkt att ge vägledning till förbättrad förmåga att hantera framtidens samhällsstörningar. Bakom texterna står sju olika författare som utgått från ambitionen att publicera ett transp

Background - This interim 12-month analysis is a part of an open-label, observational, prospective study on health outcomes and cost impact of levodopa/carbidopa intestinal gel (LCIG, Duodopa) in Parkinson disease (PD). The specific aim was to investigate clinical and health-related quality of life (HRQoL) effects in routine care. Methods - Unified PD rating scale (UPDRS) was the primary efficacy

N. antarctica occurs in the widest range of habitat types among all South American Nothofagus. The aim of this Study is to investigate adaptive responses by variation in morphological (tree form and leaf characters), and environmental traits (soils) of the polymorphic N. antarctica. Also we analyze the effect of genetic drift and limited gene flow in such predominantly apomict by means of neutral

Enriching the surface density of immobilized capture antibodies enhances the detection signal of antibody sandwich microarrays. In this study, we improved the detection sensitivity of our previously developed P-Si (porous silicon) antibody microarray by optimizing concentrations of the capturing antibody. We investigated immunoassays using a P-Si microarray at three different capture antibody (PSA

Gösta Bluhm, Institutet för miljömedicin, Karolinska Institutet: Ljudstress, vindkraft och hälsa, Eja Pedersen, Halmstad Högskola & Lunds universitet: Närboendes upplevelser av ljud från vindkraftverk, Stefan Larsson, Rättssociologi, Lunds universitet: Vindkraftsutbyggnaden – vem bestämmer och baserat på vilken kunskap? Erik Skärbäck, avdelningen för landskapsarkitektur SLU, Alnarp: Hur mycket

Riternas förändring i det moderna Sverige inleder ett temanummer i Svensk Teologisk Kvartalskrift där olika forskare vill diskutera hur olika religiösa traditioner genomgår rituell förändring på grund av migration, sekularisering och modernitet i dagens Sverige.

A mathematical model for calculating the nonisothermal moisture transfer in building materials is presented in the article. The coupled heat and moisture transfer problem was modeled. Vapor content and temperature were chosen as principal driving potentials. The coupled equations were solved by an analytical method, which consists of applying the Laplace transform technique and the Transfer Functi