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Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and
Abstract 4-Alkenyl- and 4-acyloxazoles represent important substructures across a diverse array of bioactive molecules. Practical methods to synthesize these motifs are, therefore, of considerable interest. Here, we develop a novel domino process wherein a cycloisomerization is followed by a 1,2-rearrangement via an oxazolonium ion to yield 4-alkenyloxazoles from an abundant β-chloro-N-benzyl prop4-Alkenyl- and 4-acyloxazoles represent important substructures across a diverse array of bioactive molecules. Practical methods to synthesize these motifs are, therefore, of considerable interest. Here, we develop a novel domino process wherein a cycloisomerization is followed by a 1,2-rearrangement via an oxazolonium ion to yield 4-alkenyloxazoles from an abundant β-chloro-N-benzyl propargylamin
Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of thi
This article describes practitioners’ motivations to work with daylighting and their educational needs, explored through the Goal Framing Theory (GFT) lens. The study is based on the results of 14 focus groups with 64 daylight experts from Denmark, Italy, Poland, and Sweden. The results, analysed through the GFT, revealed that experts’ motivations were driven by normative, hedonic, and gain goals
OBJECTIVE: To qualitatively explore the perceptions of Para athletes, coaches and stakeholders of the implementation, use and effects of the health promotion intervention 'Safe and Healthy Para sport' (SHAPE). A secondary aim was to explore participants' perceptions of how safety and health in Para sport could be further developed.METHODS: As part of a process evaluation, this qualitative, descrip
Framväxten och övergången till en alltmer kunskapsbaserad ekonomi har de senaste decennierna omformat grunderna för arbete, möjligheter och politiska attityder i de flesta avancerade ekonomier. Mycket av den offentliga och akademiska debatten har i detta sammanhang betonat ökande regionala klyftor, växande ojämlikheter, ökad osäkerhet, minskad social rörlighet och i kölvattnet av detta också ett vThe transformation to the knowledge economy has reshaped the foundations of work, opportunity, and political sentiment across advanced democracies. Much of the public and academic debate has emphasized deepening regional divides, increasing inequalities, growing precarity, the erosion of upward mobility, and growing social discontent.This PhD thesis explores the geographies of low-income work in S
Scholar-activism—academic scholars engaging in some form of activism—has recently become a prominent phenomenon as we witness calls for scholars to engage in political, social, and environmental causes that go beyond their traditional academic duties. An emerging literature focuses on scholar-activism as an object of study. However, the literature is scattered across rather disconnected discipline
Avhandlingen handlar om samtida föräldraskap och skärmtid. Skärmtid används ofta i vardagligt språkbruk för att beteckna aktiviteter på och kring skärmteknologier, men det har även blivit ett fenomen som ofta beskrivs i termer av konfrontation, osäkerhet och frustration i hemmet (Livingstone & Blum-Ross 2020; Sandberg et al. 2024a). Föräldrar förväntas hantera och kontrollera deras barns skärmThe dissertation is about modern-day parenting in relation to what is commonly known as screen time. While screen time in everyday language is used to connote activities on screen technologies, it has become a phenomenon which often describes a site of struggle, uncertainty and frustration in the domestic space (Livingstone & Blum-Ross 2020; Sandberg et al. 2024a). Parents are expected to mana
The X-ray flux from X-ray free-electron lasers and storage rings enables new spatiotemporal opportunities for studying in-situ and operando dynamics, even with single pulses. X-ray multi-projection imaging is a technique that provides volumetric information using single pulses while avoiding the centrifugal forces induced by conventional time-resolved 3D methods like time-resolved tomography, and
Recent findings suggest that cartilage mechanical function may be a biomarker for early osteoarthritis (OA) pathology. Thus, the development of methodologies for in-vivo applications has expanded. However, when creep tests are performed, inconsistency in applied stress and testing duration impede meaningful comparisons. Therefore, this study investigates the impact of creep duration on cartilage m
This paper reports results from an exploratory experimental study (N = 181) comparing an effort based public good game to a standard public good game — each presented in a gain and a loss frame. The data show lower average contributions and more free-riders in the effort treatments, with the most notable effect showing for men in the loss frame (comparing standard vs. effort, contributions drop fr
Trichotillomania is an understudied, underrecognized, and difficult-to-treat psychiatric disorder that affects about 1–2% of the population, predominantly women. This study aimed to characterize the sociodemographic and clinical characteristics of a Swedish cohort of individuals with a diagnosis of trichotillomania assigned in specialist services across the country. Through the Swedish National Pa
Vowel-based voice analysis is gaining attention as a potential non-invasive tool for COPD classification, offering insights into phonatory function. The growing need for voice data has necessitated the adoption of various techniques, including segmentation, to augment existing datasets for training comprehensive Machine Learning (ML) modelsThis study aims to investigate the possible effects of seg
Background: Reducing lipid levels is essential for preventing major adverse cardiovascular and cerebrovascular events (MACCE) in management of coronary artery disease (CAD) patients with obstructive sleep apnea (OSA). The first line treatment of OSA is continuous positive airway pressure (CPAP), however, its impact on the association between lipid profile and MACCEs is uncertain. Methods: This was
The biochemical composition and functions of non-sexual organs in male and female must be adjusted to support the distinct reproductive purposes of their sexual organs. The gastrointestinal (GI) tract is the primary site for the digestion and absorption of nutrients, as well as the metabolism of orally administered drugs. We utilized an in-depth proteomics approach to determine the molecular basis
In some languages, prosodic cues on word stems can be used to predict upcoming suffixes. Previous studies have shown that second language (L2) users can process such cues predictively in their L2 from approximately intermediate proficiency. This ability may depend on the mapping of the L2 prosody onto first language (L1) perceptual and functional prosodic categories. Taking as an example the Danis
This study aimed to obtain high-resolution 3D isotropic turbo spin-echo (TSE) wrist MRI acquisitions at 7T, with and without fat suppression, facilitated by compressed-sensing (CS) acceleration. In 16 healthy subjects, fat-suppressed (FS) and nonfat-suppressed (NFS) TSE wrist images were obtained. The protocol consisted of a SENSE-accelerated scan, with an isotropic voxel size of 0.45 mm and acqui
