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Breast cancer risk genes - Association analysis in more than 113,000 women
Legitimation dynamics in industrial path development : new-to-the-world versus new-to-the-region industries
While economic geography has contributed deep insights into the knowledge-related determinants of industry emergence, less is known about the legitimacy that people confer to the new industries. Based on a comparative case study in the potable water reuse industry (California, United States) and the video games industry (Hamburg, Germany), this article explores the legitimation dynamics in regiona
Evaluation of Hoffman and Xia plasticity models against bi-axial tension experiments of planar fiber network materials
The anisotropic properties and pressure sensitivity are intrinsic features of the constitutive response of fiber network materials. Although advanced models have been developed to simulate the complex response of fibrous materials, the lack of comparative studies may lead to a dubiety regarding the selection of a suitable method. In this study, the pressure-sensitive Hoffman yield criterion and th
IPMN of the pancreas–does histological subtyping allow for improved stratification and follow-up?
Acute pancreatitis–can evidence-based guidelines be transferred to an optimized comprehensive treatment program?
Acute pancreatitis is a common cause of hospitalization and has an incidence of about 300 per 1,000,000 inhabitants. A majority of patients with acute pancreatitis have mild disease, with an absence of local and systemic complications [1]. The clinical, translational, and experimental research in the field of acute pancreatitis is enormous and various guidelines exist. The guidelines have improved
Industrial packaging and its impact on sustainability and circular economy : A systematic literature review
Industrial packaging can enable efficient and sustainable logistics activities throughout supply chains. Such activities have a great impact on a company's sustainability performance. There has been an increase in research on industrial packaging and its potential to contribute to sustainable supply chains and a circular economy, but the current research is fragmented. The purpose of this study is
Taleändring efter utslag eller tredskodom
Ett praktiskt problem som kan uppstå är att en kärande vill lägga till ett yrkande på väsentligen samma grund som ett tidigare framställt yrkande efter det att ett utslag i mål om betalningsföreläggande eller en tredskodom i tvistemål meddelats mot svaranden och denne begärt återvinning. Då gäller i vissa avseenden reglerna för överrättsprocess, men i andra avseenden utgör målet en (fortsatt) tin
Rigorous Upper Bound for the Discrete Bak–Sneppen Model
Fix some p∈ [0 , 1] and a positive integer n. The discrete Bak–Sneppen model is a Markov chain on the space of zero-one sequences of length n with periodic boundary conditions. At each moment of time a minimum element (typically, zero) is chosen with equal probability, and it is then replaced alongside both its neighbours by independent Bernoulli(p) random variables. Let ν(n)(p) be the probability
Timely treatment initiation; a reminder about effort to reduce system-related lead times
Simplified Larsen erosion score (SLES) for estimating joint damage in early rheumatoid arthritis in clinical practice
Migratory orientation in inexperienced and experienced avian migrants
Massive bird migration across continents and seas is one of the most spectacular phenomena in nature, involving billions of birds annually. In the autumn, most birds on migration are juveniles migrating for the first time while adults are repeating their migrations. Migration syndrome in individual bird migrants involves multiple behavioural, morphological and physiological adaptations, and migrat
Vasodilator therapy for pulmonary hypertension in children : a national study of patient characteristics and current treatment strategies
Pulmonary vasodilator therapy is still often an off-label treatment for pulmonary hypertension in children. The aim of this nationwide register-based study was to assess patient characteristics and strategies for pulmonary vasodilator therapy in young Swedish children. Prescription information for all children below seven years of age at treatment initiation, between 2007 and 2017, was retrieved f
Network meta-analysis comparing the efficacy of biologic treatments for achieving complete resolution of nail psoriasis
Background: Nail psoriasis (NP) is common and of high importance in patients with psoriasis. Complete resolution of NP at week 24‒26 is an unambiguous nail outcome accessible for indirect treatment comparison of biologics. Objective: To evaluate the comparative efficacy of approved biologics in achieving complete resolution of NP at week 24‒26. Methods: A network meta-analysis (NMA) was conducted
Pan-genomic sequencing reveals actionable cdkn2a/2b deletions and kataegis in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a lethal malignancy characterized by poor response to conventional therapies. Whole-genome sequencing (WGS) analyses of this tumor type are limited, and we therefore interrogated eight ATCs using WGS and RNA sequencing. Five out of eight cases (63%) displayed cyclin-dependent kinase inhibitor 2A (CDKN2A) abnormalities, either copy number loss (n = 4) or trunca
RENEB/EURADOS field exercise 2019 : robust dose estimation under outdoor conditions based on the dicentric chromosome assay
Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods: For the di
Navigating unChartered waters : anchoring Athena SWAN into Irish HEIs
The UK Athena SWAN (AS) Charter was extended to Irish Higher Education Institutions (HEIs) in 2015 to provide a catalyst for change towards gender equality and to transform institutional cultures, through AS Gender Action Plans. This paper charts: the journey of Athena SWAN to Ireland; its rate of adoption by Irish HEIs; and its impact on the sector. Drawing upon the perspective and contribution o
Exploring clinical reasoning in Austrian mental health physiotherapy : the physiotherapist´s perspective
Introduction: In mental health physiotherapy, there is a lack of research investigating the assumptions and clinical reasoning strategies of the professionals. A critical view on what is taken for granted within physiotherapy promotes professional development. Purpose: The purpose of this study was to explore and describe the essence of clinical reasoning of Austrian mental health physiotherapists
Literature review of fungi in buildings and their ability to methylate chlorophenols into malodorous chloroanisoles
A source of indoor malodor in older buildings are chloroanisoles, a methylation from chlorophenols. Chlorophenols were commonly used in wood preservatives 50 years ago which were used to treat construction details exposed to high moisture loads. The methylation process requires a methylator in the form of fungi or bacteria in conjunction with adequate growth conditions for said fungi. The food ind
Robust municipal decision making? A pilot study of applying robust decision making in three Swedish municipalities
The growing understanding of the increased frequency and severity of extreme weather events due to climate change demands action. Locally, measures to adapt must be taken without knowing exactly what will happen, where it will happen or what the consequences will be. To meet this need, a number of decision support tools have been developed and this article investigates how municipalities can imple