Context: Autonomic nervous system activation mediates the increase in whole-body glucoseuptake in response to electroacupuncture but the mechanisms are largely unknown.Objective: To identify the molecular mechanisms underlying electroacupuncture-inducedglucose uptake in skeletal muscle in insulin-resistant overweight/obese women with andwithout polycystic ovary syndrome (PCOS).Design/Participants:

We are at a time when international law and the law of war are particularly important. The testing of nuclear weapons that is being used in the rhetoric surrounding threats of war is creating new fears and heightening current tensions. Richard Falk has for decades been an outspoken authority calling for nuclear disarmament and the enforcement of non-proliferation treaties. In this collection of es

In the present review, we highlight the possible “extra-immunological” effects of maternal immunoglobulins (Ig) transferred to the blood circulation of offspring, either via the placenta before birth or via the colostrum/milk across the gut after birth in different mammalian species. Using the newborn pig as a model, since they are naturally born agammaglobulinemic, intravenously (i.v.) infused pu

Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive

Biliary tract cancers (BTC) are rare and often diagnosed in late stages with advanced, nonresectable disease. The targeted agents panitumumab and bevacizumab have shown promising outcomes in combination with chemotherapy in other gastrointestinal (GI) cancers. We wanted to investigate if panitumumab or bevacizumab was the most promising drug to add to chemotherapy. Eighty-eight patients were rando

BACKGROUND: There is a lack of evidence-based recommendations for the age at which women with a family history of cancers other than breast cancer should start breast cancer screening. METHODS: Using Swedish family cancer data sets, the authors conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931 (follow-up, 1958-2015). Accounting for calendar time, they calculated

Background: Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic inflammation, all yield some prognostic value. We hypothesised that cumulative information obtained during the first three days of intensive care could produce a reliable model for

Henzinger et al. posed the so-called Online Boolean Matrix-vector Multiplication (OMv) conjecture and showed that it implies tight hardness results for several basic dynamic or partially dynamic problems [STOC'15]. We first show that the OMv conjecture is implied by a simple off-line conjecture that we call the MvP conjecture. We then show that if the definition of the OMv conjecture is generalizeHenzinger et al. posed the so-called Online Boolean Matrix-vector Multiplication (OMv) conjecture and showed that it implies tight hardness results for several basic dynamic or partially dynamic problems [STOC'15]. We first show that the OMv conjecture is implied by a simple off-line conjecture that we call the MvP conjecture. We then show that if the definition of the OMv conjecture is generalize