Photoacoustic (PA) imaging is rapidly emerging as a promising clinical diagnostic tool. One of the main applications of PA imaging is to image vascular networks in humans. This relies on the signal obtained from oxygenated and deoxygenated hemoglobin, which limits imaging of the vessel wall itself. Giant cell arteritis (GCA) is a treatable, but potentially sight- and life-threatening disease, in w

Tight binding models are widely used in large scale electronic structure calculations of nanostructures. Their atomistic nature makes them flexible, but also means the computational cost increases rapidly with system size. The large number of calculations required to design nanostructures makes computational efficiency desirable. We have developed a method to increase computational speed while ret

Objectives: Cervical nerve root compression can lead to radiculopathy in the arm. Some studies have reported low accuracy in determining the responsible nerve root in both cervical and lumbar regions. This prospective, observational, pragmatic study aimed to determine the accuracy of the clinical evaluation relative to magnetic resonance imaging (MRI) findings in patients with arm radiculopathy. M

Mathematical modelling in glucose metabolism has proven very useful for different reasons. Several models have allowed deeper understanding of the relevant physiological and pathophysiological aspects and promoted new experimental activity to reach increased knowledge of the biological and physiological systems of interest. Glucose metabolism modelling has also proven useful to identify the parame

The increasing number and complexity of urban risk and disasters have a significant bearing on the emotional and mental wellbeing of those who are exposed and hamper their responses. Nevertheless, current discourses and approaches to increase resilience tend to focus on broader socio-economic, physical and environmental systems. This reflects a failure by the academic and practitioner communities

What do your thoughts and intentions have to do with the climate crisis we are living in? Quite a lot, if we believe emerging science. Let’s look at how they influence not only our personal, but also our collective story, and why they are key for creating a more sustainable future.

Algebraic reasoning has proven to be one of the most effective approaches for verifying gate-level integer mul-tipliers, but it struggles with certain components, necessitating the complementary use of SAT solvers. For this reason validation certificates require proofs in two different formats. Approaches to unify the certificates are not scalable, meaning that the validation results can only be t

BackgroundOncoMasTR is a recently developed multigene prognostic test for early-stage breast cancer. The test has been developed in a kit-based format for decentralized deployment in molecular pathology laboratories. The analytical performance characteristics of the OncoMasTR test are described in this study.MethodsExpression levels of 6 genes were measured by 1-step reverse transcription-quantita

BACKGROUND: Serious infections have been observed in patients with inflammatory bowel disease (IBD) on anti-TNF use-but to what extent these infections are due to anti-TNF or the disease activity per se is hard to disentangle. We aimed to describe how the rates of serious infections change over time both before and after starting anti-TNF in IBD.METHODS: Inflammatory bowel disease patients naïve t

A comprehensive study of the co-evolution of globular cluster systems (GCS) in galaxies requires the ability to model both the large-scale dynamics (0.01–10 kpc) regulating their orbital evolution, and the small-scale dynamics (sub-pc – au) regulating the internal dynamics of each globular cluster (GC). In this work, we present a novel method that combine semi-analytic models of GCS with fully sel

Denna artikel behandlar hur förintelsen ska undervisas enligt den svenska skolans läroplan där den tillhör det central innehållet. Artikeln analyserar elevers responser på en fråga från det nationella provet i årskurs 9. Den diskuterar hur elever förstår förintelsen ur två perspektiv: en traditionell historisk föreståelse alternativt ett samtida moraliskt uppdrag.

Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal and gastric (EG) adenocarcinoma. The aim of this st

Startups use prototyping to develop and validate their products and business models. For startups, it is important to have a good knowledge of relevant adoption factors, to make decisions regarding which prototyping technology to adopt. In this article, we identify such factors based on our practical experiences of startups in various industries. We define a research framework, describe challenges

Precipitation is intrinsically associated with high uncertainty, which is exacerbated exponentially over time—especially concerning climate change. However, the current design practice in urban drainage infrastructure remains firmly bound to deterministic assumptions regarding the design load. This approach is too simplified—focusing only on the return period of the design event—and ignores the co

Erving Goffman’s book Frame Analysis (1974) differs from several of his other texts (e.g. the praised books The Presentation of Self in Everyday Life, Encounters, Stigma and Asylums) in that it is probably read because of Goffman’s reputation rather than because it is considered to have an indispensable message. Frame Analysis doesn’t seem to be a book that you must read. It lacks the heuristic ch