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A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

Grading and histologic typing of endometrial cancer in biopsy material has a direct impact on the decision to perform lymphadenectomy and/or omentectomy in many cancer centers. Endometrial biopsies are among the most common general surgical pathology specimens. Multiple studies have shown that biopsy diagnosis suffers from a lack of reproducibility. Although many biomarkers have been proposed, non

The Performative, Sensory, and Embodied Experiences of Heritage: Spatial Changes and Heritage Construction in Rural and Urban China

This paper is inspired by recent literature that emphasise the performative, sensory, and embodied experiences of heritage practices, as well as by the recent “spatial” turn in China studies. Both rural and urban China has undergone dramatic spatial changes since 1949 that at first were brought about by ideological and political movements and later by market economic reforms. These changes have de

The Evolving Heritagescape: Actors and Narratives in Xinye village

The threat to the rural heritage has since the 1990s become a concern for Chinesescholars and heritage experts. Today many individual buildings and whole villageshave been listed as protected sites at different levels. But long before experts began totake an interest, villagers were themselves actively involved in protecting their owntraditions and the buildings of importance to the community (in

Psychiatric diagnoses in older people with intellectual disability in comparison with the general population a register study

AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population.METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regar

Competence and confusion : How stereotype threat can make you a bad judge of your competence

Women tend to have competence doubts for masculine-stereotyped domains (e.g., math), whereas men tend to think they can handle both feminine-stereotyped and masculine-stereotyped domains equally well. We suggest that perhaps women's more frequent experience with stereotype threat can partly explain why. Our results showed that when stereotype threat was primed in high school students (n = 244), th

The currency composition of firms' balance sheets, asset value correlations, and capital requirements

We extend the Tasche (2007) model on the asset correlation bias caused by a currency mismatch between assets and liabilities to the more realistic situation where just some assets and liabilities are denominated in a foreign currency. To test the significance of the remaining bias we rely on a unique database constructed by the Inter-American Development Bank (IADB) containing time-series of the a

Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the diseas

Co-performing tourism places : The "Pink Night" festival

This paper adopts an ecological perspective to analyze the practices and processes inherent in encounters between residents and tourists. The study contributes to the literature on performance and performativity, seen as a novel theoretical approach in tourism studies, by proposing the concept of performative field, which enables a holistic and ecological consideration of the performances and rela

Reduced breast cancer mortality after 20+ years of follow-up in the Swedish randomized controlled mammography trials in Malmö, Stockholm, and Göteborg

Objective: To analyze the age- and trial-specific effects of the breast cancer screening trials with mammography in Malmö, Stockholm, and Göteborg. Methods: The original trial files were linked to the Swedish Cancer and Cause of Death Registers to obtain date of breast cancer diagnosis and date and cause of death. Relative risks and 95% confidence intervals were calculated using the evaluation mod

Bacterial Pathogenesis : Methods and Protocols

This volume discusses various methods and protocols used for the experimentation of a wide range of bacterial species, such as Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumonia, Listeria monocytogenes, and Mycobacterium marinum. Bacterial Pathogens: Methods and Protocols is divided into 6 parts: Part 1 describes different approaches to identifying and characterizing bacterial

Triaxial rotation-axis flip triggered by an isoscalar np pair

We show that the rotation axis of a triaxial nucleus may flip from the intermediate axis (γ=-30) to the smallest axis (γ=+30) due to the polarization by an aligned T=0np pair. The example we discuss is the triaxial N=Z nucleus Ge64 where the isoscalar π(g9/2)- ν(g9/2) pair aligns to iπ=9+ in As66 and flips the rotation from γ≈-30 to γ≈30. Calculations are performed in the spherical shell model as

Uses of fluorescence excitation-emissions indices in predicting water treatment efficiency

Membrane filtration is a possible alternative for the increase of the natural organic matter (NOM) content in the raw water sources in boreal areas. In a pilot study, a new hollow fiber nanofilter (HFNF) has been tested. Water from four raw water sources were treated in membrane pilot plants, and three full-scale conventional plants were sampled. Three established fluorescence indices, humificatio

Molecular Convergent Evolution of the MYBPC2 Gene Among Three High-Elevation Amphibian Species

We report a strong pattern of molecular-level convergent/parallel evolution of the MYBPC2 gene. Three high-elevation amphibian species, Bufo gargarizans minshanicus, Nanorana pleskei, Rana kukunoris, revealed remarkable numbers of convergent and parallel amino acid substitutions. On the MYBPC2 gene tree of eleven anurans, the three distantly related species formed a strongly supported clade that w

Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominated retinopathy, we identified five homozygous variants [p.(Asp594fs), p.(Gln117*), p.(Met712fs), p.(Ile756Phe), and p.(Glu543Lys)] in the polygl