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The purpose of this study was to investigate postural control in women with and without premenstrual symptoms (PMS) in three hormonally verified phases of the menstrual cycle. Thirty-two women were recruited to participate in the study and 25 of these women were included in the results. Menstrual cycle phases were determined by sex hormone analyses in serum and LH detection in urine. A prospective
Neuromuscular control is critical for maintaining dynamic joint stability and mitigating the risk of anterior cruciate ligament (ACL) injury. Given the increased risk of ACL injury in females, sex-based differential muscle activation strategies are often associated with this risk. For example, the quadriceps-dominant muscle activation strategy sometimes observed in females has been discussed as a
Background: Sex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population. Methods: An isome
Background: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extens
This commentary describes a program developed to help reduce the incidence of anterior cruciate ligament injuries in soccer players. The basic principles underlying the injury prevention protocol are described with respect to the proprioceptive control mechanisms at the knee joint. This is followed by a detailed description of the program.
Background: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. Objective: To identify sex-related differences in OA-affected
The purpose of this study was to describe neuromuscular and kinematic differences during failed and successful drop-vertical jumps in a pediatric population. Healthy young athletes (n = 32) completed single-leg drop vertical jump landings where the required landing leg was unanticipated. Trials were categorized as failed if the participant shifted their base of support during the landing. Joint ki
The modern rigid alpine ski boot has been associated with an increase in severe knee joint injuries. A new design that allows the rear portion of the upper cuff of the boot (rear spoiler) to open when a posterior directed force is applied to it (similar to when a skier falls back on the ski) is investigated. Motion analysis was combined with kinetic measures to estimate the shear and compressive f
This study investigated the clinical interpretation of three electromyographic (EMG) normalisation techniques to detect neuromuscular alterations in patients diagnosed with anterior cruciate ligament knee injury during treadmill walking. The EMG signal was normalised using the mean value during the gait cycles (MEA), the maximum value during the gait cycles (MAX), and a maximum voluntary isometric
Sex-related differences in neuromuscular activation have been previously identified and are thought to be an underlying contributor to the ACL injury mechanism. During dynamic tasks evaluating the role of muscle action as it relates to joint stability is difficult since individual muscle contributions to force generation are confounded by biomechanical factors of movement. The purpose of this stud
The auditory brainstem response (ABR) in tinnitus subjects has been extensively investigated over the last decade with the hopes of finding possible abnormalities related to the pathology. Despite this effort, the use of the ABR for tinnitus diagnosis or as an outcome measure is under debate. The present study reviewed published literature on ABR and tinnitus. The authors searched PubMed, MedLine,
Anterior cruciate ligament (ACL) injury rates in female adolescents are increasing. Irrespective of treatment options, approximately 1/3 will suffer secondary ACL injuries following their return to activity (RTA). Despite this, there are no evidence-informed RTA guidelines to aid clinicians in deciding when this should occur. The first step towards these guidelines is to identify relevant and feas
Soft tissue artefact (STA) represents one of the main obstacles for obtaining accurate and reliable skeletal kinematics from motion capture. Many studies have addressed this issue, yet there is no consensus on the best available bone pose estimator and the expected errors associated with relevant results. Furthermore, results obtained by different authors are difficult to compare due to the high v
The effect of modeling the knee as a simple spherical or revolute joint during gait, cutting and hopping were evaluated. The results indicate that, even during gait, a revolute joint may be too restrictive in its representation of the knee, with flexion/extension errors as high as 9.4°. By imposing the spherical joint, joint angles showed consistent and strong correlations with the true joint angl
Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont
The objective of this study was to supplement continuous wavelet transforms with muscle synergies in a fatigue analysis to better describe the combination of decreased firing frequency and altered activation profiles during dynamic muscle contractions. Nine healthy young individuals completed the dynamic tasks before and after they squatted with a standard Olympic bar until complete exhaustion. El
Background: Intra-tumour heterogeneity (ITH) causes diagnostic challenges and increases the risk for disease recurrence. Quantification of ITH is challenging and has not been demonstrated in large studies. It has previously been shown that deep learning can enable spatially resolved prediction of molecular phenotypes from digital histopathology whole slide images (WSIs). Here we propose a novel me
Att vara trans på olika sätt är ingen nödsituation och behöver inte vara dramatiskt. I stället för att enbart reagera i stunden kan politiker, rektorer, lärare, kuratorer, skolsköterskor och andra vuxna skapa en skola där färre spontana lösningar krävs eftersom det finns ett genomtänkt pedagogiskt och administrativt arbete, det som kallas ”whole-of-school approach” (Bartholomaeus & Riggs, 2017Being trans in different ways is not an emergency and does not have to be dramatic. Instead of reacting only in the moment, politicians, principals, teachers, counselors, nurses and other adults can create a school where fewer spontaneous solutions are needed because there is well thought-out pedagogical and administrative work, what is called the 'whole-of-school approach' (Bartholomaeus & Ri
Good hygiene, in both health care and the community, is central to containing the rise of antibiotic resistance, as well as to infection control more generally. But despite the well-known importance, the ecological mechanisms by which hygiene (or other transmission control measures) affect the evolution of resistance remain to be elucidated. Using metacommunity ecology theory, we here propose that
