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Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplastic anemia, characterized by macrocytic anemia, reticulocytopenia, and severely reduced numbers of erythroid precursors in the bone marrow. For more than fifty years, glucocorticoids have remained the main option for pharmacological treatment of DBA. While continuous glucocorticoid administration increases hemoglobin levels in a major
Abul-Kasim K, Brizzi M, Petersson J. Hyperdense middle cerebral artery sign is an ominous prognostic marker despite optimal workflow. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01277.x. (c) 2009 The Authors Journal compilation (c) 2009 Blackwell Munksgaard.Objectives - To evaluate the association between the hyperdense middle cerebral artery sign (HMCAS) and the functional outcome on one han
Functional analysis and Monte Carlo simulation were used to quantify uncertainties in model simulation of pollution behaviour and effects. The first-order part of the functional analysis method provides a measure of uncertainties in dependent variables in terms of uncertainties in independent variables. The procedure is based on first-order terms in the Taylor series expansion of the dependent var
ABSTRACT: BACKGROUND: Renal function decreases with age. Dosage adjustment according to renal function is indicated for many drugs, in order to avoid adverse reactions of medications and/or aggravation of renal impairment. There are several ways to assess renal function in the elderly, but no way is ideal. The aim of the study was to explore renal function in elderly subjects in nursing homes and
Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance and current lack of other effective treatments there is an urgent need for new therapies. We here present a new treatment concept for sepsis and endotoxin-mediated shock, based on host defense peptides fr
Basque is spoken by approximately 660,000 people (Trask 1997) in the Basque Country, straddling the border between northern Spain and southern France, particularly in rural areas of the Bizkaia and Gipuzkoa coastline, as well as inland Gipuzkoa and the foothills of the Pyrenees in Navarre. Virtually all Basque speakers are bilingual with either Spanish or French. Nevertheless, Basque is, due to it
In the present paper we give a general two-dimensional formalism for scattering in a multilayered medium with a finite inhomogeneity present. The formalism is based on the T matrix method, introduced by Waterman [J. Acoust. Soc. Am. 45, 1417 (1969)]. The formalism is developed in detail for the geometries consisting of one layer with an obstacle situated either inside or below the layer. More gene
This licentiate thesis concerns advanced digital product catalogues, with the main focus on product presentation. A computer based digital product catalogue opens new possibilities for advanced product presentation and integration into the existing compute environment. Several new possibilities for product presentation become available. By use of photorealistic rendering techniques, images showing
In the last decade or so an increasing number of researchers in Scandinavia have become interested in the research field of contentious politics studies (CPS). The result has been a growing number of publications focusing on political contention. We have now reached the point where international research networks are being set up. Several interesting workshops and book projects are underway unders
This paper develops the foundations and the implications of the mechanisms proposed as possible triggers for the demographic transition and the process of socio-economic development. In particular it examines the role played by gender equality and its significance for the understanding of the development process which allowed economies to move out of a long period of stagnation into a state of sus
Objectives: Skeletal muscle performance is determined by muscle temperature. This paperpresents a review of the research literature to contribute to a better understanding of thephysiological mechanisms of muscle fatigue and performance in cold exposure and in repetitiveor sustained physical exertion in terms of isometric maximal force production,electromyographic activities, and gait ground react
The cysteinyl-leukotrienes (cysLTs: LTC4, LTD4 and LTE4) have an important pathophysiological role in asthma. They are not only extremely potent bronchoconstrictors, but are also involved in the central mechanisms of the asthmatic inflammation and the subsequent remodelling of the airways. Allergen-induced bronchoconstriction as well as spontaneous exacerbations of asthma are associated with incre
This work concerns experimental and numerical studies of pressure drop and heat transfer for turbulent flow inside a U-duct and in particular the bend part. Such duct geometries can be found in many engineering applications where cooling air extracts heat from hot internal walls of the duct, e.g., passage cooling inside gas turbine blades. The details of the duct geometry were as follows: the cros
BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored tri- and diglycerides, thus mobilizing fatty acids. HSL exhibits broad substrate specificity and besides acylglycerides it hydrolyzes cholesteryl esters, retinyl esters and lipoidal esters. Despite its role in fatty acid mobiliza
Popular Abstract in Swedish En burk målarfärg som har lämnats bortglömd, en senapsflaska som länge har stått upprätt i ett kylskåp eller ett nyinköpt filmjölkspaket som precis ska öppnas. Det finns många vardagliga situationer där vi stöter på separation av fasta partiklar från vätskan i så kallade suspensioner. Separationsprocessen kallas sedimentering och är den tillämpning som genomgående motivA consistent theme throughout this thesis is quasilinear partial differential equations (PDEs) appearing in one-dimensional models of sedimentation for solid-liquid separation of suspensions. We mainly focus on continuous sedimentation in so-called clarifier-thickeners (CTs), which are found in mineral processing and wastewater treatment. In addition to complications with shocks and non-unique sol
An interpretation is given of the threshold photoelectron spectrum of Ar between the P-3 and D-1 double-ionization thresholds. In this region the observed spectrum is less cluttered than below the P-3 thresholds and the interpretation is more straightforward. One of the characteristic features of the spectrum is the excitation to Rydberg orbitals with high angular momentum l in agreement with the
