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High-dose naloxone : Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioid-receptor inverse agonists reinstate hypersensitivity to nociceptive stimuli. This unmasking of latent pain sensitization has been a consistent finding in roden

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Der Artikel geht der Rolle des Irrtums in Per Olov Enquists DokumentarromanLegionärerna (1968, Die Ausgelieferten) nach, der die Auslieferungvon baltischen Militärflüchtlingen an die Sowjetunion durch den schwedischenStaat im Jahr 1946 behandelt. In einem ersten Schritt wird aufgezeigt,inwiefern die Kategorie des Irrtums zentrale thematische und narrativeFunktionen in Enquists Romanarchitektur erf

Catholic Celebrities, Religious Commodities and Commotions in the Light of Swedish Anti-Catholicism

In the Protestant tradition the trade and commerce that surrounded different aspects of Catholic spirituality was regarded as something relatively alien. In Protestant Sweden the critique towards these aspects of Catholicism became an essential component in the anti-Catholic rhetoric that was recurring during the latter nineteenth and the early twentieth century. From the perspective of Lutheran t

Focal Adhesion Isolation Assay Using ECM-Coated Magnetic Beads

Focal adhesions are force sensitive structures that dynamically alter their composition, protein-protein interactions, and signaling in response to external mechanical stimuli. These dynamic changes are critical for focal adhesion function and are required for cellular mechanosensing. Here, we describe a simple protocol that allows for isolation of the focal adhesion complex from adherent cells in

Top quark pair production at complete NLO accuracy with NNLO+NNLL′ corrections in QCD

We describe predictions for top quark pair differential distributions at hadron colliders, by combining the next-to-next-to-leading order quantum chromodynamics calculations and next-to-leading order electroweak corrections with double resummation at the next-to-next-to-leading logarithmic accuracy of threshold logarithms and small-mass logarithms. To the best of our knowledge, this is the first s

How Do Damascenes Spend Their Leisure Time during the War?

Beginning in December 2010, the Arab world was hit by huge anti-government revolutionary waves, popularly known as the Arab Spring. In Syria, the uprising did not take long to morph into a bloody war with international and regional powers wrestling for geopolitical influence and economic gain. The war has significantly changed Syria in terms of politics, economy, and culture. While the first two h

Holding course : Civil society organizations’ value expressions in the Swedish legislative consultation system before and after 2015

Contrary to the general trend in European countries since the 2000s, Sweden has neither restricted its migration policy nor limited the rights of migrants. This changed with the ‘refugee crisis’ of 2015 when the government introduced policy changes to curb the number of arrivals and impede the granting of residence permits. Civil society organizations are significantly involved in the reception of

4MOST Survey Strategy Plan

The current status of and motivation for the 4MOST survey strategy, as developed by the Consortium science team, are presented here. Key elements of the strategy are described, such as sky coverage, number of visits and total exposure times in different parts of the sky, and how to deal with different observing conditions. The task of organising the strategy is not simple, with many different surv

Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016 : A hospital-based test-negative case-control study in Lithuania

Objective A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season. Methods A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the season

Comparatively low attendance during Human Papillomavirus catch-up vaccination among teenage girls in the Netherlands : Insights from a behavioral survey among parents

Background: The Dutch Human Papillomavirus (HPV) catch-up vaccination program in 2009 appeared less successful than expected. We aimed to identify the most important determinants of refusing the vaccination. Methods: Two thousand parents of girls born in 1996 targeted for HPV vaccination received an invitation letter to participate in a questionnaire study. Two study groups were defined: the first

Gallery construction and oviposition of the bark beetle Ips typographus (Coleoptera : Scolytidae) at different breeding densities

Abstract. 1. The bole of a Norway spruce, Picea abies(L.) Karst., was cut in 25 cm sections and infested in the laboratory with 2 or 8 females/dm2 of Ips typographus (L.) and an equal number of males. 2. One log of each beetle density was dissected every second day, beginning 2 days after female introduction. 3. The oviposition rate was highest at the beginning of the breeding period for both dens

Causes and effects of individual quality in bark beetles

A summary of the present knowledge of variation in individual quality within a bark beetle population is given, with emphasis on the spruce bark beetle Ips typogrophus, A major causal factor is density, mediated by competition during larval development. Density negatively influences individual quality measured as weight, fat content and pheromone production. Together with decreasing mean values at

Effects of pheromone trap type, position and colour on the catch of the pine sawfly Neodiprion sertifer (Geoff.) (Hym., Diprionidae)

Two novel easy‐to‐make pheromone traps, a cross‐barrier sticky trap and an open horizontal sticky trap, are described. Both types caught about the same number of male pine sawflies, Neodiprion sertifer, when baited with the synthetic pheromone (2S, 3S, 7S)‐3,7‐dimethylpentadec‐2‐yl acetate. The catch on unbaited cross‐barrier traps was about 17% compared with baited traps, whereas unbaited horizon

Differences in morphology and sexual size dimorphism between the Dutch elm disease vectors Scolytus laevis and Scolytus scolytus (Col., Scolytidae)

The external differences between the well‐documented S. scolytus and the little studied S. laevis are clarified with the help of SEM micrographs of the frons and abdomen of both sexes of the two species. The convex frons of both male and female S. scolytus is densely covered with short hairs. S. laevis males have a flat frons with long hairs in a pair of bundles, whereas the females have a convex