Background: No targeted drugs are currently available against small cell lung cancer (SCLC). BCL-2 family members are involved in apoptosis regulation and represent therapeutic targets in many malignancies. Methods: Expression of BCL-2 family members in 27 SCLC cell lines representing all known four SCLC molecular subtypes was assessed by qPCR, Western blot and mass spectrometry-based proteomics.

Background: A high level of competence among staff is necessary for providing patient-safe surgical care. Knowledge regarding what factors contribute to the professional development of specialist nurses in surgical care and why they choose to remain in the workplace despite high work requirements is needed. To investigate and describe the organizational and social work environment of specialist nu

Background: Participatory research has been described to improve the relevance of research findings for the society in terms of quality of healthcare services and other public benefits. Nevertheless, there is limited guidance on how to conduct participatory research, and especially in relation to persons living in residential care facilities. To make the voices of this group heard, we therefore ta

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other

Background: Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of

Background: Preventing and responding to gender-based violence (GBV) is both a human rights imperative and a multifaceted economic issue. GBV can also act as a barrier to economic empowerment. The aim of the study was to examine the association between women’s empowerment (physical mobility, decision making and economic resources) and GBV among married youth in India. Methods: Community based cros

Objectives: Detecting particle flow from the airways by a non-invasive analyzing technique might serve as an additional tool to monitor mechanical ventilation. In the present study, we used a customized particles in exhaled air (PExA) technique, which is an optical particle counter for the monitoring of particle flow in exhaled air. We studied particle flow while increasing and releasing positive

Hydrogen (H2) and methanol (MeOH) are promising fuels for sustainable transport, owing to their ideal properties for use in internal combustion engines: CO2 neutral (when produced renewably), ultralow emissions, and high efficiencies. The dual-fuel (DF) technology where diesel is used as a pilot to ignite port fuel injected H2 or MeOH is of particular interest for retrofitting existing diesel engi

• AimThe aim of this study is to unravel the potential of atmospheric thinking for place brand communication research. As such, it explores how place branding can be understood as a process of communicatively crafting ‘strategic atmospheres’, namely as a process of constituting specific affective and sensory relatings to urban space. • Theoretical framework The theoretical argument is informed by

We consider a version of the Erdős–Rothschild problem for families of graph patterns. For any fixed k≥3, let r0(k) be the largest integer such that the following holds for all 2≤r≤r0(k) and all sufficiently large n: The Turán graph Tk−1(n) is the unique n-vertex graph G with the maximum number of r-edge-colorings such that the edge set of any copy of Kk in G is rainbow. We use the regularity lemma

Scheimpflug lidar is a compact alternative to traditional lidar setups. With Scheimpflug lidar it is possible to make continuous range-resolved measurements. In this study we investigate the feasibility of a Scheimpflug lidar instrument for remote sensing in pool flames, which are characterized by strong particle scattering, large temperature gradients, and substantial fluctuations in particle dis

Individual milk samples were used to investigate how much of the variation in rennet gelation properties that can be explained by variation in milk composition by linear regression using the ordinary least squares method so as to optimise cheese milk. Natural variation in casein (CN) content was shown to have a large effect on gel strength but did not affect gel formation kinetics. Ionic calcium c

När vi människor försöker röra på oss skickas elektriska impulser genom nervsystemet från hjärnan ner till de muskler som är inblandade i den tilltänkta rörelsen. Att kunna mäta sådana nervimpulser hade varit av värde för en rad tillämpningar—information hade då kunnat överföras direkt från nervsystemet utan att gå via långsamma, mekaniska gränssnitt så som tangentbord och pekskärmar. OlyckligtvisElectrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invas

Critical scholarship on the intersection of development pathways and climate change responses highlights the roles of power, agency, social difference, intersecting inequalities, and social justice in shaping people's resilience in a rapidly transforming world. Yet, how to precisely increase the spaces in which people experiencing marginalisation can address power asymmetries and strengthen their

Ground-level fine particulate matter (PM2.5) and ozone (O3) are air pollutants that can pose severe health risks. Surface PM2.5 and O3 concentrations can be monitored from satellites, but most retrieval methods retrieve PM2.5 or O3 separately and disregard the shared information between the two air pollutants, for example due to common emission sources. Using surface observations across China span

The aim was to study associations between trust in regional politicians responsible for the healthcare system and mortality in survival analyses. A public health survey in southern Sweden with a 54.1% response rate based on a postal questionnaire and three postal reminders was conducted in 2008. The baseline survey was linked to 8.3-year follow-up all-cause, cardiovascular (CVD), cancer and other

Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False