Filetype
Pile driving and other activities in the built environment cause ground vibration at low frequencies. This may result in annoyance to people as well as damage to civil structures. It is known that masses added on the ground surface can have an impact on the vibration levels in the surrounding environment. Hence, employing a semi-analytical model for rigid blocks on the surface of a layered ground,
Aim: Although patients with Lynch syndrome have an increased risk of developing colorectal cancer, surveillance can reduce morbidity and mortality. Whether or not affected individuals benefit from lifetime surveillance depends on individual factors and patient adherence, and these may vary, complicating risk modelling. The aim of this study was to identify individual factors which influence patien
The essay is an attempt to distinguish between the semantic notion of "childfree" and that of "voluntary childlessness" taking into account the Russian specifics. The author consistently describes socio-political content of the Russian research field emphasizing the conservative pro-natal trends of the recent years. The paper considers the origins of the conceptual field of non-parenthood and the
In the present paper, linear substructures with nonlinearities localized at their interfaces, such as the joints in a beam structure, are studied. By subdivision of the total structure into substructures, reduced subsystems are obtained by component mode synthesis. Nonlinear elements are introduced at supports or between substructures. A numerical example is presented where a beam subjected to bla
Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a ‘mainstream’ investiga
Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammator
Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries
In the early eighteenth century, the Sicilian volcano Etna was still primarily familiar to European culture through its many classical associations. This chapter examines the interaction between classical accounts of Etna and other, developing genres of describing and representing that mountain in the writings of some famous eighteenth-century travelers and ‘natural philosophers’. In paving the wa
Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a low prevalence among most solid tumours (<1%), the first encouraging results with pan-NTRK tyrosine kinase i
Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click
The radiography profession in Sweden is young but has been rapidly changing over the recent years. The developing profession has led to radiographers facing various challenges related to responsibility for both the technical equipment and patient care in the periradiographic process. Further education is urgent to keep up with the arising level of competence required. The study aimed to explore ra
