Identification of risk factors for osteoporosis has been essential for understanding the development of osteoporosis and related fragility fractures. A polymorphism of the binding site for the transcription factor Sp1 of the collagen I alpha 1 gene (COLIA1) has shown an association to bone mass and fracture, but the findings have not been consistent, which may be related to population differences.

Due to increasing demand for software project managers in industry, efforts are needed to develop the management-related knowledge and skills of the current and future software workforce. In particular, university education needs to provide to their computer science and software engineering (SE) students not only technology-related skills but, in addition, a basic understanding of typical phenomen

Symtomen vid diastolisk hjärtsvikt skiljer sig inte från dem vid systolisk funktionsnedsättning. Nya rön har framkommit om förekomsten och betydelsen av symtom och hur de bedöms av patienter och sjukvårdspersonal. Bakomliggande mekanismer till diastolisk rubbning presenteras här utifrån cellulära mekanismer och bakomliggande sjukdomar såsom hypertoni, diabetes och övervikt.

The story of how conflict prevention became an integral and legitimate part of Swedish foreign policy illustrates the relationship between successful practices and powerful ideas. This article suggests that the demonstration of an idea in practice empowers the idea and contributes not only to its selection, but also to its framing and institutionalization within foreign policy. Hence, the article

Current state of the art suggests the use of variational formulations for solving a variety of computer vision problems. This thesis deals with such variational problems which often include the optimization of curves and surfaces. The level set method is used throughout the work, both as a tool in the theoretical analysis and for constructing practical algorithms. One frequently occurring example

Artikel om efterkrigstidens bruk av förintelsen.

Hormone-sensitive lipase (HSL) is expressed and enzymatically active in beta-cells and has been proposed to be involved in the generation of the lipid-derived signal that seems to be necessary for glucose-stimulated insulin secretion. In this study, we investigated whether the expression of HSL in INS-1 cells and in rat islets is affected by exposure to high glucose concentrations. Incubation of I

Oxidative stress, or the production of oxygen-centered free radicals, has been hypothesized as the major source of DNA damage that in turn can lead to altered genetic expression, disease, and aging of humans. Serum protein thiol levels in blood are a direct measure of the in vivo reduction/oxidation (redox) status in humans, because thiols react readily with oxygen-containing free radicals to form

Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated

The purpose of this study was to characterize the emissions of a large number of chemical compounds emitted from birch wood combustion in a wood stove. Birch wood is widely used as fuel in Swedish household appliances. The fuel load was held constant during six experiments. Particles < 2.5 mum diameter were collected and the size distribution of the particles was measured. The results were compare

Several factors influence the accuracy to which information on the in vivo activity concentration can be obtained from SPECT images. The accuracy in image contrast and the quantitation of volume and activity has here been examined for a SPECT system aimed for absorbed dose determinations in systemic radiation therapy. The influence of source dimensions, object contrast, noise level, energy window

BACKGROUND: Gastrin and cholecystokinin (CCK) are thought to exert trophic effects on the gastrointestinal tract and pancreas. Two types of receptors have been cloned, CCK-A and CCK-B/ gastrin. We have examined the occurrence of CCK-A and CCK-B receptor mRNA in the brain, digestive tract, pancreas, and kidney of the rat and man by Northern blot and reverse transcribed polymerase chain reaction (RT

We used a proboscis extension reflex (PER) to study the olfactory discrimination capability in the moth Spodoptera littoralis. Already after a single experience, moths were capable to discriminate a rewarded from an unrewarded odor. In the first experiment, when rewarded and unrewarded odors were substituted for each other, moths were able to undergo reversal conditioning already after two experie

The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt

Breakup reactions were used to study the ground-state configuration of the neutron-rich isotope 23O. The 22O fragments produced in one-nucleon removal from 23O at 938 MeV/nucleon in a carbon target were detected in coincidence with de-exciting γ rays, allowing to discern between 22O ground-state and excited-states contributions. From the comparison of exclusive experimental momentum distributions

In the history of English language research on computerised corpora, the year 1977 marks an important event with the birth of ICAME - the International Computer Archive of Modern and Medieval English - which set off international co-operation on a large scale. The use of computer corpora, from being a fringe activity, has become a mainstream methodology. Yet there was corpus life also before ICAME