SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients remain largely asymptomatic despite high levels of glutarate in the urine. To study the disease mechanism, we generated SugctKO mice and uncovered imb

Chemokines are important in the development and progression of tumors. We investigated the expression of CXCL14 and CXCL16 in colon cancer. Expression of mRNA was assessed in primary tumors and lymph nodes and CXCL16 mRNA levels were correlated to patient’s survival. Protein expression was investigated by two-color immunofluorescence and immunomorphometry. CXCL14 and CXCL16 mRNA levels and protein

Importance: Breast cancer screening guidelines acknowledge the need for earlier screening for women at increased risk but provide limited guidance for women with a family history of breast cancer. A risk-adapted starting age of screening for relatives of patients with breast cancer may help supplement current screening guidelines. Objective: To identify the risk-adapted starting age of breast canc

This chapter presents my analytical journey from conviviality, a concept used for analysing diversity in Istanbul to overcome the pitfalls of multiculturalism and coexistence theories, to the development of the concept of convivial solidarity for the analysis of transnational civil society organisations that support refugees and migrants in Denmark. Convivial solidarity is my construct and I use i

We present a generalisation of the flavour-ordering method applied to the chiral nonlinear sigma model with any number of flavours. We use an extended Lagrangian with terms containing any number of derivatives, organised in a power-counting hierarchy. The method allows diagrammatic computations at tree-level with any number of legs at any order in the power-counting. Using an automated implementat

Hybridization is a natural process at species range boundaries, but increasing numbers of species are hybridizing due to direct or indirect human activities. In such cases of anthropogenic hybridization, subsequent introgression can threaten the survival of native species. To date, many such systems have been studied with too few genetic markers to assess the level of threat resulting from advance

In this work, the possibility of using planar droplet sizing (PDS) based on laser-induced fluorescence (LIF) and Mie scattering was investigated within the framework of measuring the droplet Sauter mean diameter (SMD) of direct-injection spark-ignition (DISI) spray systems. For this purpose, LIF and Mie signals of monodisperse fuel droplets produced by a droplet generator were studied at engine re

Root-induced channels are the primary controlling factors for rapid movement of water and solute in forest soils. To explore the effects of root distribution on preferential flow during rainfall events, deciduous (Quercus variabilis BI.) and coniferous forest (Platycladus orientalis (L.) Franco) sites were selected to conduct dual-tracer experiments (Brilliant Blue FCF and Bromide [Br-]). Each plo

Concerns have been raised about the potential adverse effects of liberalizing trade in services under the GATS framework on equity, costs, distribution, availability of services and sovereignty of governments in defining their national objectives. These concerns have been voiced in poor countries in case of such social service sectors as health and education. Critics have stressed the need for an

Based on a comparative study of the social economic development and the water resources characteristics in 13 arid inland basins of north-western China, it is pointed out that oasis will move from lower reach to upper reach in the circumstances of lower water availability per capita and poorer social economic structures. A significant ecological warning line and warning interval of oasis evolvemen

Background: Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). We controlled for physical inactivity, smoking, depression and alexithymia. Methods: Cross sectional study of 190 T1D patients (86 women/104 men, 18-59 years, diabetes duration 1-5

Experimental aerosol generation methods aim to represent natural processes; however, the complexity is not always captured and unforeseen variability may be introduced into the data. The current practices for natural and experimental aerosol generation techniques are reviewed here. Recommendations for best practice are presented, and include characterization of starting material and spray fluid, r

The problems of neutrino masses, matter-antimatter asymmetry, and dark matter could be successfully addressed by postulating right-handed neutrinos with Majorana masses below the electroweak scale. In this work, leptonic decays of W bosons extracted from 32.9 fb−1 to 36.1 fb−1 of 13 TeV proton–proton collisions at the LHC are used to search for heavy neutral leptons (HNLs) that are produced throug

At the conference of the International Society for the Scholarship of Teaching and Learning (ISSOTL) in Bergen, Norway (October 2018), we were privileged to have heard a lecture by Elizabeth Minnich, “People who are not thinking are capable of anything: What are students learning, how are students learning it, and does it make them better people?”In November 2018, as a follow-up to the lecture, Ch

Direct Fick method is considered a standard reference method for estimation of cardiac output. It relies on indirect calorimetry to measure oxygen consumption. This is important as only a minor measurement error in oxygen consumption can result in false estimation of cardiac output. A number of studies have shown that indirect calorimetry overestimates oxygen consumption in adults. The aim of this

In this paper we present fully decentralized methods for calculating an approximate zero- forzing (ZF) equalizer in a large intelligent surface (LIS). A LIS is intended for wireless communication and facilitates unprecedented MU- MIMO performance, far superior to that of Massive MIMO. Antenna modules in the grid connect to their neighbors to exchange messages of information needed for interference

With increasing number of wirelessly connected devices having limited energy resources, energy efficient solutions become more and more important. Many studies have addressed schemes where low-power wake-up receivers are used to improve energy efficiency in networks with low traffic intensity (per node) and demands on availability. One such scheme is the duty-cycled wake-up receiver medium access

In this paper, full-and sub-structure characteristic modes (CMs) are explored through the effect of coupling between the target and background structures. The eigenvalues and eigen-current distributions of the first few modes are compared for different coupling levels in the numerical example. Similarities and differences between the two types of CMs in specific conditions are revealed, paving the

This paper presents a broadside antenna with three ports operating at the same frequency. The TM030 and TM003 modes of a patch are excited by two coaxial cables to generate two orthogonal linear polarizations. The patch can be transformed into a slotted SIW cavity whose TE201 and TE102 modes are jointly excited by the third cable. A matching cavity and a matching patch are introduced to broaden th