Popular Abstract in Swedish Prostatacancer drabbar män över hela världen; i Sverige får ungefär 10 000 personer diagnosen varje år. För den enskilda individen kan följderna innebära fysiskt och psykiskt lidande, men även samhället belastas med höga vårdkostnader. För att undvika onödigt lidande, men också minska kostnaderna är det nödvändigt att ta fram nya läkemedel och metoder för att i god tid The aims of this thesis were to identify microRNAs (miRNAs) with prostate cancer prognostic and diagnostic potential, to discover miRNAs with therapeutic capacity against prostate cancer, and to investigate if prostate specific antigen (PSA) is miRNA regulated. Prostate cancer is a globally spread disease with low mortality, but some patients develop an aggressive lethal form of prostate cancer w

BACKGROUND: Due to increasing resistance development among bacteria, antimicrobial peptides (AMPs), are receiving increased attention. Ideally, AMP should display high bactericidal potency, but low toxicity against (human) eukaryotic cells. Additionally, short and proteolytically stable AMPs are desired to maximize bioavailability and therapeutic versatility. METHODOLOGY AND PRINCIPAL FINDINGS: A

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A combination of NMR chemical shift imaging and self-diffusion experiments is shown to give a detailed molecular picture of the events that occur when tablets of hydrophobically modified poly(acrylic acid) loaded with a drug (griseofulvin) swell in water in the presence or absence of surfactant (sodium octylbenzenesulfonate). The hydrophobic substituents on the polymer bind and trap the surfactant

Heat treatment of barley husks was performed to extract arabinoxylan with high yield and high weight-averaged molecular mass (M(W)). Microwave irradiation was employed for initial screening of suitable residence times (2-15min), temperatures (120-210 degrees C) and initial pH (3-13) of the reaction slurry. Microwave irradiation was shown to be a good method for predicting the effects of heat treat

Ankylosing Spondylitis (AS) is a chronic, potentially disabling, inflammatory disease that poses a longstanding burden on the patient and the society. The epidemiology of AS in Sweden has not been extensively studied previously. Radiographic and self-perceived health information from 1,005 men aged 69-81 years, showed a prevalence of moderate to severe radiographic sacroiliitis of 1.4% (95% Confid

During severe storms high waves and water levels may greatly impact the sub-aerial portion of the beach inducing significant morphological change at elevations that the waves can not reach under normal conditions. Morphological formations such as dunes and barrier islands may suffer from direct wave impact and erode. Overwash occurs if the wave run-up and/or the mean water level are sufficiently h

We show atomically resolved scanning tunneling microscopy (STM) images of charge density waves (CDWs) at room temperature together with angle-resolved photoelectron band-mapping of 1T-TaSe2. By comparing the results of these two techniques, we demonstrate the atomic structure of the CDW-features observed by the STM and atomic origin of the reconstructed band-structure in this material. (c) 2007 El

The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from

Most musculoskeletal soft tissue tumors are benign, lipoma being the most common. Malignant soft tissue tumors may be difficult to clinically distinguish from benign.Scandinavian recommendations are that all lesions suspicious for sarcoma be referred to a sarcoma center. This has led to improved tumor control and less post-operative functional deficits.Magnetic resonance imaging (MRI) can reliably

The analytical method described, based on antibody-antigen bio-recognition and the measuring system for amperometric detection, was designed for accurate, easy to use and cost effective quantification of calpastatin, a meat tenderness biomarker. The novel assay for calpastatin quantification was integrated in a portable electrochemical device known as the Tendercheck system and was used to analyze

Background. The aim of this study was to determine the relationship between single-nucleotide polymorphisms (SNPs) in MRP2 genes and mycophenolic acid (MPA) pharmacokinetics in renal transplant recipients of the Symphony Pharmacogenomic substudy. Methods. Sixty-six renal transplant recipients of eight Spanish centres were randomized into four branches of immunosuppressive regimen: low dose of cycl

The coadsorption of water and preadsorbed oxygen on Ru{0001) was studied by synchrotron-based high-resolution x-ray photoelectron spectroscopy. A dramatic change was observed in the interaction of water with oxygen between low and high oxygen precoverages. Low oxygen coverages below 0.18 ML induce partial dissociation, which leads to an adsorbed layer of H2O and OH. Around half the oxygen atoms ta

Context: The individual variability in the waning androgenic-anabolic functions of aging men may be influenced by the CAG repeat polymorphism in exon 1 of the androgen receptor (AR), affecting androgen sensitivity. However, findings on its phenotypic effects are inconclusive. Objective: To investigate the relationships between health status, various reproductive hormones and the AR CAG repeat leng

Charge transfer pathways and charge transfer times in molecular films and in adsorbate layers depend both on the details of the electronic structure as well as on the degree of the initial localization of the propagating excited electronic state. For C6F6 molecular adsorbate films on the Cu(111) surface we determined the interplay between excited state localization and charge transfer pathways. In

Context: A summary of the 2nd International Consultation on Bladder Cancer recommendations on the reconstructive options after radical cystectomy (RC), their outcomes, and their complications. Objective: To review the literature regarding indications, surgical details, postoperative care, complications, functional outcomes, as well as quality-of-life measures of patients with different forms of ur

During more than three decades, corporate non-financial and sustainability reporting has been widely conceived as a voluntary practice, a matter of going beyond the requirements of the law. Therefore, it has been traditionally overlooked by legal and socio-legal scholars. However, during the last decade things have rapidly changed. We are currently witnessing the emergence of a mix of mandatory a