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EHA–EU MCL network guidelines for diagnosis and treatment of mantle cell lymphoma

Mantle cell lymphoma (MCL) is a relatively rare B-cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 mutations. Most often, patients present with disseminated dis

Exploring blended learning : benefits and challenges of integrating face-to-face and online teaching

This paper explores the integration of face-to- face and online teaching modalities to develop blended learning within higher education at Lund University.By examining the advantages and challenges of both approaches through a comprehensive literature review and semi-structured interviews with experienced educators, we aim to identify strategies that maximize student engagement and learning outcom

Verification of Pathologic ECV Estimated with Clinical T1 Mapping Methods Using an Isotope-based Reference

Purpose: To verify the accuracy of clinically used cardiac MRI T1 mapping sequences for measuring extracellular volume fraction (ECV) throughout the spectrum of pathologic values using an independent reference standard. Materials and Methods: Acute myocardial ischemia was induced in six pigs using endovascular balloon occlusion in the left anterior descending artery between October 2018 and Novemb

Evaluation of kidney function and damage in patients with hemophilia B—insights from the B-Natural study

Background: Patients with hemophilia are reported to have a high prevalence of established and potential risk factors for kidney dysfunction and damage. However, comprehensive studies specifically evaluating kidney function in hemophilia, particularly hemophilia B (HB), are limited, with most research focusing on hemophilia A. Objectives: This study aimed to assess markers of glomerular filtration

Small water supplies in Nordic countries : climate change effects, risks and contingency planning

Climate change (CC) is altering the working conditions for water suppliers. To enhance preparedness, CC has been emphasised in the risk-based approach (RBA) and water safety planning guidelines. We studied how the RBA approach has been applied in small water supplies in the Nordic countries to mitigate CC related risks and impacts. We interviewed small water supply operators and authorities in eac

The shock of the old : How a local currency’s transition from digital to paper deepened monetary conscientization

“Now that it doesn’t come from the phone, where is the money coming from?” asks a member of Wazee Hukumbuka during one of the farmers’ cooperative’s community meetings. Silas, a local leader knowledgeable about community currencies, answers swiftly. “As Wazee Hukumbuka, you are paying members for their seeds from a sort of cooperative fund. That’s where the money is coming from. It’s just that you

Sedation, temperature and pressure after cardiac arrest and resuscitation—The STEPCARE trial: A statistical analysis plan

Background: Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets for blood pressure and managing sedation and temperature. However, optimal targets and management are unknown. Methods: The STEPCARE (Sedation, Temperature and Pressure after Cardiac Arrest and Resuscitation) trial is a multicent

Beyond growth in food systems : Cultivating seeds of change

The Special Section on Post-growth food systems for a just social-ecological transition within planetary boundaries explores post-growth and degrowth approaches that advocate for sufficiency, care, regeneration, and the democratization of food systems. It shows that post-growth food initiatives face multiple structural barriers, including capitalist systems that prioritize profit over ecological a

WUISHOW : A digital collaborative wildfire evacuation platform

This paper presents the WUISHOW, a digital collaborative evacuation decision-making tool designed to assist wildland-urban interface (WUI) fire stakeholders in emergency management and response. The tool has been developed with a dual scope: 1) to allow assessment of end users needs and 2) to allow visualisation through procedural generation of the results of wildfire evacuation simulations. The W

Effect of PEM Fuel Cell Technology Advancement on the Energy Efficiency of a Heavy-Duty Vehicle

Fuel cell hybrid electric vehicles (FCHEVs) are a promising solution for decarbonizing heavy-duty transport by combining hydrogen fuel cells with battery storage to deliver long range, fast refuelling, and high payload capacity. However, many existing simulation models rely on outdated fuel cell parameters, limiting their ability to reflect recent technological improvements and accurately predict

Type 1 and type 2 diabetes mellitus among people with intellectual disability in comparison to the general population : A register study (IDcare)

Aims: To assess the prevalence and prevalence relative risk (PRR) of Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) among people with intellectual disabilities (ID) compared to the general population using a register-based cohort in Sweden. Methods: The study included 14,716 people with ID and 1226,955 people from the general population in Skåne, Sweden, on January 1st, 2014.

Nucleosynthesis of Cobalt and Copper

Chemical abundances of cobalt (Co; Z = 27) and copper (Cu; Z = 29) in bulge and halo stars are presented and compared with chemical evolution models. The aim is to distinguish if Co and Cu are dominantly produced by neutron-capture or the alpha-rich freeze-out processes. Neutron-capture can be identified by a secondary behaviour in the [X/Fe] vs. [Fe/H] plot, and alpha-rich freeze-out would give r

Non-Native Bird Populations Respond Differently to Their Environment and Exhibit Shifts in Ecological Niche Limits Across Continents

Aim: The degree to which species' niches remain stable over space and time–the niche conservatism hypothesis–is critical for predicting species' responses to environmental change. Tests of this hypothesis typically focus on changes in niche centroids and boundaries. An outstanding question is whether species' environmental associations differ within the interior of their niche space–that is, acros

The Start of a Plastic Breakdown Journey : Investigating Enzymes for Plastic Breakdown

Plast är ett av våra vanligaste material i vardagen. Som helhet är det ett billigt, slitstarkt och lätt material. Det finns olika typer av plast med olika egenskaper. Gemensamt för alla plaster är dock att de består av (oftast en typ av) molekyler som sitter ihop i långa, repeterande kedjor. Dessa kedjor kallas polymerer. När plast slängs i naturen eller hanteras fel som avfall finns det en risk aAs plastic pollution in aquatic environments persists, gaining a deeper understanding of nanoparticles has become increasingly important. Yet, the question remains: what happens to plastic as it breaks down into smaller components, and ultimately, what end products are formed? Current plastic degradation methods are limited in their environmental applicability and efficiency. This study aims to pr

A Mixed Method Pilot Feasibility Study of a Symptom Management Support Intervention for Heart Transplant Recipients With Chronic Pain and Extensive Symptom Distress

Background: The aim of heart transplantation is prolonged survival and improved quality of life. Chronic pain is a common and distressing symptom after heart transplantation. To our knowledge, there are no person-centred interventions aimed at chronic pain and symptom distress after heart transplantation. The aim was to assess the feasibility and acceptability of systematic, person-centred symptom

Validation of the GPAT - the Global Polypectomy Assessment Tool : European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

Background Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy. Methods GPAT was derived from the ESGE Curriculum for