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Do Assistive Products Enhance or Equalize Opportunities? A Comparison of Capability across Persons with Impairments Using and Not Using Assistive Products and Persons without Impairments in Bangladesh
Aiming to compare capability across persons with impairments using and not using assistive products and persons without impairments in Bangladesh for 16 different functionings, we contrast two sets of self-reported cross-sectional data from eight districts of Bangladesh: (i) data from persons with hearing impairment not using hearing aids, persons with hearing impairment using hearing aids and per
Dialysis as a Novel Adjuvant Treatment for Malignant Cancers
Cancer metabolism is characterized by an increased utilization of fermentable fuels, such as glucose and glutamine, which support cancer cell survival by increasing resistance to both oxidative stress and the inherent immune system in humans. Dialysis has the power to shift the patient from a state dependent on glucose and glutamine to a ketogenic condition (KC) combined with low glutamine levels—
Borylation in the Second Coordination Sphere of FeIICyanido Complexes and Its Impact on Their Electronic Structures and Excited-State Dynamics
Second coordination sphere interactions of cyanido complexes with hydrogen-bonding solvents and Lewis acids are known to influence their electronic structures, whereby the non-labile attachment of B(C6F5)3resulted in several particularly interesting new compounds lately. Here, we investigate the effects of borylation on the properties of two FeIIcyanido complexes in a systematic manner by comparin
Fatty acid 16:1ω5 as a proxy for arbuscular mycorrhizal fungal biomass : current challenges and ways forward
Fatty acid biomarkers have emerged as a useful tool to quantify biomass of various microbial groups. Here we focus on the frequent use of the fatty acid 16:1ω5 as a biomarker for arbuscular mycorrhizal (AM) fungi in soils. We highlight some issues with current applications of this method and use several examples from the literature to show that the phospholipid fatty acid (PLFA) 16:1ω5 can occur i
Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due to inflammatory bowel disease (PHOSPHARE-IBD) : A randomised clinical trial
Objective: Intravenous iron - a common treatment for anaemia and iron deficiency due to inflammatory bowel disease (IBD) - can cause hypophosphataemia. This trial compared the incidence of hypophosphataemia after treatment with ferric carboxymaltose (FCM) or ferric derisomaltose (FDI). Design: This randomised, double-blind, clinical trial was conducted at 20 outpatient hospital clinics in Europe (
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clinical development (PhIIb) as an inhaled treatment of idiopathic pulmonary fibrosis. To enable treatment of systemically galectin-3 driven disease, we h
Community-onset urosepsis : incidence and risk factors for 30-day mortality–a retrospective cohort study
Background: Urosepsis is a life-threatening condition that needs to be addressed without delay. Two critical issues in its management are: (1) Appropriate empirical antibiotic therapy, considering the patients general condition, comorbidity, and the pathogen expected; and (2) Timing of imaging to identify obstruction requiring decompression. Objectives: To identify risk factors associated with 30-
Addendum to national survey on copyright flexibilities in Sweden
Follow-up and addendum survey on national public sources of copyright flexibilities in Sweden, focusing on copyright exceptions and limitations, public domain, user rights and public interest. Part of ReCreating Europe project WP2 - End Users.
Sparse optimization for nonlinear group delay mode estimation
Nonlinear group delay signals with frequency-varying characteristics are common in a wide variety of fields, for instance, structural health monitoring and fault diagnosis. For such applications, the signal is composed of multiple modes, where each mode may overlap in the frequency-domain. The resulting decomposition and forming of time-frequency representations of the nonlinear group delay modes
Parkinsonism in Genetic Neurodevelopmental Disorders : A Systematic Review
Background: With advances in clinical genetic testing, associations between genetic neurodevelopmental disorders and parkinsonism are increasingly recognized. In this review, we aimed to provide a comprehensive overview of reports on parkinsonism in genetic neurodevelopmental disorders and summarize findings related to genetic diagnosis, clinical features and proposed disease mechanisms. Methods:
GIS and Tourism: Developing strategies for new touristic flows after the Covid-19 pandemic
The goal of this article is to propose, through the use of GIS software, an interdisciplinary method to suggest new touristic flows after the Covid-19 pandemic. Specifically, the aim is to identify those sites of cultural and landscape interest that are little known but with great artistic, cultural, historical and environmental value that could give new vigour to the tourism sector. In the first
Active and Physics-Based Human Pose Reconstruction
Perceiving humans is an important and complex problem within computervision. Its significance is derived from its numerous applications, suchas human-robot interaction, virtual reality, markerless motion capture,and human tracking for autonomous driving. The difficulty lies in thevariability in human appearance, physique, and plausible body poses. Inreal-world scenes, this is further exacerbated b
ProTstab2 for Prediction of Protein Thermal Stabilities
The stability of proteins is an essential property that has several biological implications. Knowledge about protein stability is important in many ways, ranging from protein purification and structure determination to stability in cells and biotechnological applications. Experimental determination of thermal stabilities has been tedious and available data have been limited. The introduction of li
Starting a Swedish national quality registry for orthognathic surgery : a tool for auditing fundamentals of care
BACKGROUND: National quality registries (NQRs) provide open data for user-directed acquisition. National Quality Registry (NQR) data are often used to analyze the rates of treatment success and adverse events for studies that aim to improve treatment quality and patient satisfaction. Thus, NQRs promote the goal of achieving evidence-based therapies. However, the scientific literature seldom focuse
Fluid Management, Intra-Abdominal Hypertension and the Abdominal Compartment Syndrome : A Narrative Review
Background: General pathophysiological mechanisms regarding associations between fluid administration and intra-abdominal hypertension (IAH) are evident, but specific effects of type, amount, and timing of fluids are less clear. Objectives: This review aims to summarize current knowledge on associations between fluid administration and intra-abdominal pressure (IAP) and fluid management in patient
Multi-Stage Phase-Segregation of Mixed Halide Perovskites under Illumination : A Quantitative Comparison of Experimental Observations and Thermodynamic Models
Photo- and charge-carrier-induced ion migration is a major challenge when utilizing metal halide perovskite semiconductors for optoelectronic applications. For mixed iodide/bromide perovskites, the compositional instability due to light- or electrical bias induced phase-segregation restricts the exploitation of the entire bandgap range. Previous experimental and theoretical work suggests that exci
Differences in subjective well-being between individuals with distinct Joint Personality (temperament-character) networks in a Bulgarian sample
Background. Personality is the major predictor of people’s subjective well-being (i.e., positive affect, negative affect, and life satisfaction). Recent research in countries with high-income and strong self-transcendent values shows that well-being depends on multidimensional configurations of temperament and character traits (i.e., Joint Personality Networks) that regulate the way people learn t
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