BACKGROUND: Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo. In ischemic stroke, the progression of pathology involves changes in microvascular signal

Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cell

Purpose: This paper aims to focus on academic library managers’ learning practices in the context of cooperative work supported by computational artefacts. Academic library managers’ everyday work is mainly cooperative. Their cooperation is supported predominantly by computational artefacts. Learning how to use the computational artefacts efficiently and effectively involves understanding the chan

Photoredox properties of several earth-abundant light-harvesting transition metal complexes in combination with cobalt-based proton reduction catalysts have been investigated computationally to assess the fundamental viability of different photocatalytic systems of current experimental interest. Density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations using several GGA (BP86, B

Aims: To determine the magnitude of the association between abdominal adiposity and low-grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities. Materials and Methods: We measured waist circumference, clin

Effectively utilizing Big Data can be a challenge for many companies. Due to its volume, many aspects of the data processing pipeline such as storage, retrieval and usage may quickly become problematic. For example, it could be difficult identifying the relevant metrics when analyzing a service failure. Visualizing and deriving insights from the data could also prove to be quite onerous. Immersive

Animal migration has fascinated scientists and the public alike for centuries, yet migratory animals are facing diverse threats that could lead to their demise. The Anthropocene is characterised by the reality that humans are the dominant force on Earth, having manifold negative effects on biodiversity and ecosystem function. Considerable research focus has been given to assessing anthropogenic im

To decipher the dispersal range of the cosmopolitan green microalga Tetracystis vinatzeri, two airborne-collected strains were barcoded using the 18S ribosomal DNA gene (18S) and the mitochondrial cytochrome c oxidase I subunit (COI), and their survival capacities were investigated across a stepwise acidic to alkaline pH gradient. Genetic fingerprinting confirmed the identity of the strains as rep

Little is known on the spreading capacities of Limnomonas gaiensis across freshwater lakes in Northern Europe. In this study, we show that the species could successfully be aerosolized from water sources by bubble bursting (2-40 particles.cm−3), irrespectively of its density in the water source or of the jet velocity used to simulate wave breaking. The species viability was impacted by both water

The ecological niche of the recently described limnic microalga Limnomonas gaiensis (Chlamydomonadales) in Northern Europe remains unknown. To decipher the species tolerance capacity to pH, the effects of hydrogen ions on the physiological response of L. gaiensis were investigated. Results showed that L. gaiensis could tolerate exposure from pH 3 up to pH 11, with an optimal survival at pH 5–8. It

The scale of movement associated with the migration of many intra-African bird species is still poorly known even with the increasing availability of tracking devices. In this study, we tracked the movements of Black Coucals Centropus grillii breeding in Nigeria from late July using satellite telemetry. Individuals remained on the breeding site for several months; two individuals transmitted after

Taking the recent UN Report about extreme poverty in the UK as a point of departure, this article analyses and assesses William Cavanaugh’s political ecclesiology. Drawing on the interpretation of Martin Luther’s concept of creation in Scandinavian Creation Theology, I argue that creation destabilises the distinction Cavanaugh draws between what he considers to be church and what he considers not

Whatever else it takes to drive a taxi, it takes trust. Day after day, the driver has to decide whether the other is or is not trustworthy. I take the taxi as a test case to analyze and assess Richard Kearney’s diacritical hermeneutics of the other. I argue that Kearney functionalizes the concept of transcendence in order to connect the transcendence of the finite other to the transcendence of the

As of 1 June 2018, the symbol of the cross has to be shown in all state offices of Bavaria in Germany. In order to chart the churches’ reaction, I return to a conversation that Robert N. Bellah and Martin E. Marty had during the 1960s and the 1970s. Drawing on the core concepts of this conversation, I analyze and assess today’s cross controversy as a case of what I call the ‘populist predicament’.

For theologians such as Karl Barth the support for Germany’s militaristic ambitions and actions voiced in the manifesto "An die Kulturwelt", published in 1914, was a consequence of the historicization of theology. Ernst Troeltsch (1865-1923), whose interdisciplinary thinking revolved around the significance of history for theology, was labeled the theologian of historicism. Although he had not sig

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √s = 13 TeV recorded by the LHCb experiment in th

The production rate of Λb0 baryons relative to B0 mesons in pp collisions at a center-of-mass energy s=13 TeV is measured by the LHCb experiment. The ratio of Λb0 to B0 production cross sections shows a significant dependence on both the transverse momentum and the measured charged-particle multiplicity. At low multiplicity, the ratio measured at LHCb is consistent with the value measured in e+e-