Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP. This brief review will highlight some of the more recent work in this field and highlight other findings that pr

We present a study of the early stage of ripple formation on Ge(001) surfaces irradiated by a 1 keV Xe+ ion beam at room temperature and near-normal incidence. A combination of a grazing incidence x-ray scattering technique and atomic force microscopy allowed us to observe a variation of the symmetry of the surface nanopattern upon increase of the ion fluence. The isotropic dot pattern formed duri

Silicon and Teflon substrates have been structured by wet etching and a focused ion beam (FIB) to obtain very defined, clean apertures. Planar, free-standing lipid membranes (black lipid membranes (BLM)) with enhanced long-term stability have been prepared on these apertures by the methods of Montal and Müller1.2 as well as Müller and Rudin. 3 The stability and geometric control enables the use of

This work is focused on synthesis, characterization, and determination of main parameters of the multilayer P123 templated TiO2 films. The mesoporous multilayer thin films consist of TiO2 nanoparticles on the F-doped SnO2 (FTO) conductive glass substrates. The films were grown by implementing the protocol of supramolecular templating with the amphiphilic triblock copolymer, Pluronic P123. The temp

A compact portable vacuum-compatible chamber designed for surface X-ray scattering measurements on beamline ID01 of the European Synchrotron Radiation Facility, Grenoble, is described. The chamber is versatile and can be used for in situ investigation of various systems, such as surfaces, nanostructures, thin films etc., using a variety of X-ray-based techniques such as reflectivity, grazing-incid

We report on periodic ripple formation on Si(001) surfaces after bombardment with Xe+ ions with energies between 5 and 35 keV under incidence angles of 65° and 70°. The sputter process leads to the formation of a rippled amorphous surface layer, followed by a rippled interface toward crystalline material. Using grazing-incidence small-angle scattering and diffraction, we show that the surface morp

Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to neuronal cells through surface-catalyzed generation of toxic oligomers. Detailed knowledge of the fibril structure may thus facilitate therapeutic development. We use small-angle scattering to provide informati

TiO2(B) mesoporous thin films were grown in two steps on the F-doped SnO2 conductive glass substrates. In the first step, a small amount of H3PO4, corresponding to 0.15-0.375 wt % P on TiO2 basis, was introduced into concentrated HCl which was subsequently used for hydrolysis of titanium ethoxide. The hydrolyzed colloidal TiO2 suspension was further mixed with a 1-butanol solution of the amphiphil

Support for developing a work identity hasbeen shown to be essential for the recovery process ofyoung adults with mental health problems. Sinceresearch shows that the development of a student roleduring the educational years for these young adultsmay be interrupted, this time period may be relevant toexplore in order to support career development and thecritical transition to adulthood for this ta

The current threats of climate change connected to the unsustainable consumption of fossil resources paired with an increasing world population demands the exploration of alternative raw materials for the production of food, fuel and specialty chemicals. Agricultural waste streams present suitable sources due to their availability in large quantities at low costs without competing with current foo

Heparin-binding protein (HBP) is a promising biomarker for the development and severity of sepsis. To guide its use, it is important to understand the factors that could lead to false-positive or negative results, such as inappropriate release and inadequate clearance of HBP. HBP is presumably released only by neutrophils, and the organs responsible for its elimination are unknown. In this study,

Electromagnetic form factors serve to explore the intrinsic structure of nucleons and their strangeness partners. For the decay S0 ? ?e+e-, due to limited phase space, the effects caused by the Sigma-to-Lambda transition form factors compete with the QED radiative corrections. These corrections are addressed in the present work, evaluated beyond the soft-photon approximation, i.e., over the whole

Within the Standard Model Effective Field Theory framework, with operators up to dimension 6, we perform a model-independent analysis of the lepton-flavour-violating processes involving tau leptons. Namely, we study hadronic tau decays and l-t conversion in nuclei (l = e, µ). Based on available experimental limits, we establish constraints on the Wilson coefficients of the operators contributing t

T. Larspers har presenterat en väl genomarbetad presentation utifrån flera aspekter av det kristna livet kring Siljansbygden vid sekelskiftet 1800-1900. Han har visat att lokalhistoria inte bara handlar om beskrivningar av det lokala utan är både informationsberikande och har en förklaringspotential som förutsätter både resultat från kvalificerad forskning och fördjupande reflektion.

Molekylär kunskap om tumörutveckling leder till allt fler målinriktade cancerbehandlingar.Heltäckande molekylär tumörkarakterisering ger möjlighet att undersöka samtliga behandlingsalternativ med en analys.Arbetsutskottet för solida tumörer inom Genomic Medicine Sweden samarbetar för att etablera regional och nationell infrastruktur för storskalig tumörsekvensering och kopplad dataanalys i sjukvårRapidly expanding knowledge of the molecular landscape of cancers has resulted in the implementation of an increasing number of specific therapies targeted at tumors with specific molecular aberrations. In response to this development, new tools for predictive testing for molecular targets need to be implemented in routine health care. To achieve robust future molecular diagnostic pathology, and e

Precisionsmedicin i form av specifik molekylär dia­gnostik och skräddarsydd behandling är sedan länge standard för flera hematologiska sjukdomar.Vid mer komplexa hematologiska maligniteter är genpanelsekvensering i dag ett viktigt diagnostiskt verktyg och utgör grund för prognostisk bedömning och riktad behandling.Genpanelsekvensering kan även påvisa ärftlig predisposition för vissa hematologiska Precision diagnostics and therapy have been implemented rather early in clinical hematology due to the easy accessibility of blood and bone marrow, allowing not only for consecutive genetic analysis at diagnosis, remission and relapse, but also for culturing these cells and testing new drugs in vitro. One contributing factor has also been the relatively low number of »driver« mutations in hematolo